lprF
- Type
- protein_coding
- Name
- lprF
- Locus Name
-
Rv1368
- Product
-
Probable conserved lipoprotein LprF
- Functional Category
-
Cell wall and cell processes
- Location
- 1541020..1541805 (+ strand)
- Gene Length
- 785 bp
- Nucleotides
-
TGAATGGCTTGATCTCACAAGCGTGCGGCTCCCACCGACCCCGGCGCCCCTCGAGCCTGGGGGCTGTCGCGATCCTGATCGCGGCGACACTTTTCGCGACTGTCGTTGCGGGGTGCGGGAAAAAACCGACCACGGCGAGCTCCCCGAGTCCCGGGTCGCCGTCGCCGGAAGCCCAGCAGATCCTGCAAGACAGTTCCAAGGCGACGAAGGGCCTGCATTCCGTCCACGTGGTGGTGACGGTAAACAATCTCTCGACCCTCCCGTTTGAGAGCGTCGATGCCGACGTGACCAACCAACCGCAGGGCAATGGCCAGGCGGTGGGCAACGCCAAGGTCAGAATGAAGCCCAACACCCCGGTGGTGGCCACCGAGTTCCTGGTCACGAACAAGACCATGTACACGAAGCGGGGCGGCGACTATGTCTCGGTGGGTCCGGCGGAGAAGATCTATGACCCGGGCATCATCCTGGACAAGGACCGGGGGCTGGGCGCGGTCGTCGGGCAAGTGCAAAACCCGACAATCCAGGGACGTGACGCCATCGACGGCCTGGCCACCGTCAAGGTGTCCGGGACCATCGACGCCGCGGTGATCGATCCGATCGTGCCTCAGCTAGGTAAGGGTGGGGGCAGGCTCCCGATAACCTTGTGGATCGTCGACACCAACGCCTCAACGCCGGCACCCGCCGCGAACCTGGTGCGGATGGTCATTGACAAGGACCAAGGCAACGTCGACATCACGCTGTCCAATTGGGGTGCGCCGGTCACCATCCCGAACCCGGCGGGATAA
- Drug Resistance
- Mutations
- Function
- Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis). {ECO:0000250|UniProtKB:P65315, ECO:0000269|PubMed:12581360}.
- Family
-
LppX/LprAFG lipoprotein family
- GO
-
- cell wall GO:0005618 cellular_component
- extracellular region GO:0005576 cellular_component
- plasma membrane GO:0005886 cellular_component
- lipid binding GO:0008289 molecular_function
- lipid transport GO:0006869 biological_process
- InterPro
Summary
- Name
- Putative diacylated glycolipid transporter LprF (Lipoprotein LprF)
- Family
- LppX/LprAFG lipoprotein family
- Protein Sequence
-
MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG
- Mass
- 26,852 Da
- Length
- 261 Aa
Rv1368 doesn't seem to be a targeted by any drug.
Rv1368 doesn't seem to be involved in any pathway.
- Lipoproteins of slow-growing Mycobacteria carry three fatty acids and are N-acylated by apolipoprotein N-acyltransferase BCG_2070c.
- BMC Microbiol. 2013 Oct 5;13:223. doi: 10.1186/1471-2180-13-223.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Cloning, expression and characterization of Mycobacterium tuberculosis lipoprotein LprF.
- Biochem Biophys Res Commun. 2010 Jan 1;391(1):679-84. doi: 10.1016/j.bbrc.2009.11.120. Epub 2009 Nov 26.
- Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.
- Mol Microbiol. 2003 Feb;47(4):1075-89.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.