Gene - combatTB X

Rv1372

Type: protein_coding
Name: Rv1372
Locus Name: Rv1372
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 1544825..1546006 (+ strand)
Gene Length: 1181 bp
Nucleotides: TGAACGTCTCAGCTGAGAGCGGTGCGCCGCGCCGGGCCGGCCAGAGGCATGAGGTTGGCCTTGCCCAGTTGCCGCCGGCTCCGCCCACCACGGTGGCGGTGATTGAAGGGCTTGCGACGGGCACGCCGCGTCGGGTAGTCAACCAGTCCGACGCCGCCGATCGGGTCGCCGAGCTTTTCCTCGATCCCGGTCAGCGGGAACGGATTCCGCGGGTGTATCAAAAATCGCGGATCACCACGCGCCGGATGGCGGTCGACCCGCTCGACGCCAAATTTGATGTCTTCAGGCGGGAACCTGCGACGATCCGTGATCGGATGCATCTGTTCTACGAACACGCGGTTCCGCTGGCGGTGGACGTGAGCAAGCGTGCCCTGGCCGGCCTGCCATACCGTGCCGCCGAGATCGGGCTGCTGGTGTTGGCCACCAGCACCGGATTCATCGCGCCGGGCGTGGACGTTGCGATCGTCAAAGAGCTCGGGCTCTCCCCGTCGATATCACGTGTCGTGGTCAATTTCATGGGATGTGCCGCCGCGATGAATGCCCTGGGCACCGCCACCAACTATGTTCGTGCCCACCCGGCCATGAAGGCGCTGGTGGTGTGTATCGAATTGTGCTCGGTGAACGCTGTTTTTGCCGACGACATCAACGACGTCGTCATTCACAGCTTGTTTGGCGACGGGTGCGCGGCGTTGGTGATCGGCGCCAGCCAGGTTCAGGAGAAGCTCGAGCCAGGCAAGGTGGTAGTCCGCAGTAGTTTCAGTCAGCTGCTCGACAACACCGAAGACGGTATCGTGCTTGGCGTCAATCACAACGGCATCACCTGCGAGCTGTCGGAGAATCTCCCCGGCTACATCTTCAGCGGGGTCGCACCGGTGGTGACAGAGATGTTATGGGACAATGGATTACAGATATCCGATATCGATCTCTGGGCGATCCATCCGGGTGGCCCCAAGATCATCGAGCAGTCGGTGCGCTCGCTGGGGATCTCCGCGGAGCTGGCGGCGCAGAGCTGGGACGTGCTCGCCCGCTTCGGCAACATGCTCAGCGTATCGCTTATCTTTGTGCTAGAGACGATGGTGCAGCAGGCGGAGTCGGCCAAAGCCATCTCGACGGGGGTGGCGTTCGCGTTCGGGCCGGGCGTCACTGTCGAAGGCATGCTGTTCGACATCATCCGACGGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. {ECO:0000269|PubMed:12941968}.

Family

Thiolase-like superfamily, Chalcone/stilbene synthases family

GO

chalcone biosynthetic process GO:0009715 biological_process
transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 molecular_function
fatty acid biosynthetic process GO:0006633 biological_process

InterPro

UniProt: P9WPF1
GenBank: Rv1372
EnsemblBacteria: Rv1372
Mycobrowser: Rv1372

Summary

Name: Alpha-pyrone synthesis polyketide synthase-like Pks18 (EC 2.3.1.-) (Alpha-pyrone synthesis polyketide synthase type III Pks18) (Chalcone synthase-like protein) (CHS-like)
Family: Thiolase-like superfamily, Chalcone/stilbene synthases family
Protein Sequence: MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Mass: 42,032 Da
Length: 393 Aa

Rv1372 doesn't seem to be a targeted by any drug.

Rv1372 doesn't seem to be involved in any pathway.

A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.: Nat Struct Mol Biol. 2004 Sep;11(9):894-900. doi: 10.1038/nsmb809. Epub 2004 Aug 1.
A new family of type III polyketide synthases in Mycobacterium tuberculosis.: J Biol Chem. 2003 Nov 7;278(45):44780-90. doi: 10.1074/jbc.M306714200. Epub 2003 Aug 26.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.