Gene - combatTB X

PPE20

Type: protein_coding
Name: PPE20
Locus Name: Rv1387
Product: PPE family protein PPE20
Functional Category: Pe/ppe
Location: 1561769..1563388 (+ strand)
Gene Length: 1619 bp
Nucleotides: TGACCGAGCCGTGGATAGCCTTCCCTCCCGAGGTGCACTCGGCGATGCTGAACTACGGTGCGGGCGTTGGGCCGATGTTGATCTCCGCCACGCAGAATGGGGAGCTCAGCGCCCAATACGCAGAAGCGGCATCAGAGGTCGAGGAATTGTTGGGGGTGGTGGCCTCCGAGGGATGGCAGGGGCAAGCCGCCGAGGCGTTTGTCGCCGCGTACATGCCGTTTCTGGCGTGGCTGATCCAAGCCAGCGCCGACTGCGTGGAAATGGCCGCCCAGCAACACGTCGTCATCGAGGCCTACACTGCCGCGGTAGAGCTGATGCCTACTCAGGTCGAACTGGCCGCCAACCAAATCAAGCTCGCGGTGTTGGTAGCGACCAATTTCTTTGGCATCAACACCATTCCCATTGCGATCAATGAGGCCGAGTACGTGGAGATGTGGGTTCGGGCCGCCACCACGATGGCGACCTATTCAACAGTCTCCAGATCGGCGCTCTCCGCGATGCCGCACACCAGCCCCCCGCCGCTGATCCTGAAATCCGATGAACTGCTCCCCGACACCGGGGAGGACTCCGATGAAGACGGCCACAACCATGGCGGTCACAGTCATGGCGGTCACGCCAGGATGATCGATAACTTCTTTGCCGAAATCCTGCGTGGCGTCAGCGCGGGCCGCATTGTTTGGGACCCCGTCAACGGCACCCTCAACGGACTCGACTACGACGATTACGTCTACCCCGGTCACGCGATCTGGTGGCTGGCTCGAGGCCTCGAGTTTTTTCAGGATGGTGAACAATTTGGCGAACTGTTGTTCACCAATCCGACTGGGGCTTTTCAGTTCCTCCTCTACGTCGTTGTGGTGGATTTGCCGACGCACATAGCCCAGATCGCTACCTGGCTGGGCCAGTACCCGCAGTTGCTGTCGGCTGCCCTCACTGGCGTCATCGCCCACCTGGGAGCAATAACTGGTTTGGCGGGCCTATCCGGCCTGAGCGCCATTCCGTCTGCTGCGATACCCGCCGTTGTACCGGAGCTGACACCCGTCGCGGCCGCGCCGCCTATGTTGGCGGTCGCCGGGGTGGGCCCTGCAGTCGCCGCGCCGGGCATGCTCCCCGCCTCAGCACCCGCACCGGCGGCAGCGGCCGGCGCCACCGCAGCCGGCCCGACGCCGCCGGCGACTGGTTTCGGAGGCTTCCCGCCCTACCTGGTCGGCGGTGGCGGCCCAGGAATAGGGTTCGGCTCGGGACAGTCGGCCCACGCCAAGGCCGCGGCGTCCGATTCCGCTGCAGCCGAGTCGGCGGCCCAGGCCTCGGCGCGTGCGCAGGCGCGTGCTGCACGGCGGGGCCGCTCGGCGGCGAAGGCACGTGGCCATCGTGACGAATTCGTCACGATGGACATGGGTTTCGACGCGGCAGCTCCGGCCCCAGAGCACCAGCCGGGTGCCCGGGCGTCCGACTGTGGTGCGGGACCTATCGGATTTGCTGGCACGGTGCGCAAAGAGGCGGTCGTGAAAGCGGCGGGGTTGACCACGCTGGCCGGTGACGACTTCGGCGGCGGCCCAACGATGCCGATGATGCCCGGCACCTGGACCCATGATCAGGGCGTGTTCGACGAGCATCGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

extracellular region GO:0005576 cellular_component

InterPro

UniProt: P9WI23
GenBank: Rv1387
EnsemblBacteria: Rv1387
Mycobrowser: Rv1387

Summary

Name: Uncharacterized PPE family protein PPE20
Family: Mycobacterial PPE family
Protein Sequence: MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLLYVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPPYLVGGGGPGIGFGSGQSAHAKAAASDSAAAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQPGARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAGDDFGGGPTMPMMPGTWTHDQGVFDEHR
Mass: 55,404 Da
Length: 539 Aa

Rv1387 doesn't seem to be a targeted by any drug.

Rv1387 doesn't seem to be involved in any pathway.

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.: Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi: 10.1073/pnas.1523321113. Epub 2016 Jan 4.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.