dfp
- Type
- protein_coding
- Name
- dfp
- Locus Name
-
Rv1391
- Product
-
Probable DNA/pantothenate metabolism flavoprotein homolog Dfp
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1565441..1566697 (+ strand)
- Gene Length
- 1256 bp
- Nucleotides
-
TGGTGGACCATAAACGGATCCCCAAGCAGGTAATAGTCGGTGTCTCCGGGGGCATCGCCGCCTACAAGGCGTGCACGGTTGTTCGTCAACTCACCGAGGCCAGTCATCGCGTCCGAGTCATTCCCACCGAATCCGCCCTGCGCTTCGTCGGTGCCGCGACCTTCGAGGCGCTCTCCGGTGAGCCGGTGTGCACCGACGTTTTCGCCGACGTTCCGGCGGTCCCGCATGTTCACCTCGGCCAGCAGGCCGATCTGGTCGTAGTGGCGCCGGCCACCGCCGACCTGCTGGCCCGCGCGGCGGCCGGTCGAGCCGACGATCTGCTGACCGCGACGCTGCTGACGGCGCGGTGTCCGGTGCTGTTCGCGCCGGCGATGCACACCGAGATGTGGTTGCATCCGGCCACCGTCGACAACGTGGCCACGCTGCGCCGCCGCGGCGCGGTGGTGCTCGAGCCCGCGACAGGACGGCTTACCGGCGCCGACAGCGGGGCCGGCCGACTGCCCGAGGCGGAGGAGATCACCACCCTCGCCCAGCTGCTGCTGGAGCGGCACGACGCCCTGCCCTACGATCTCGCGGGGCGAAAGCTGCTGGTTACCGCCGGTGGCACACGCGAGCCGATCGATCCGGTGCGCTTTATCGGCAACCGCAGCTCCGGCAAGCAGGGCTATGCGGTGGCGCGGGTGGCCGCCCAGCGCGGCGCCGACGTTACTTTGATCGCTGGGCATACCGCAGGGCTCGTCGATCCCGCCGGCGTCGAGGTGGTGCACGTCAGCTCGGCCCAGCAACTCGCCGACGCGGTGTCCAAGCACGCTCCGACCGCCGACGTATTGGTGATGGCGGCGGCCGTCGCCGACTTCCGGCCCGCGCAGGTTGCCACCGCCAAAATCAAGAAAGGCGTCGAAGGCCCACCGACCATCGAGCTGCTGCGCAACGACGACGTGCTGGCCGGGGTGGTGCGGGCCCGAGCCCATGGACAACTGCCCAACATGCGGGCCATTGTGGGCTTCGCAGCCGAGACCGGCGACGCCAATGGCGACGTGCTCTTTCATGCCCGAGCTAAACTGCGACGCAAAGGCTGCGATCTGTTAGTCGTCAATGCCGTCGGCGAAGGCAGGGCCTTTGAGGTAGACAGCAACGACGGCTGGCTACTGGCGTCCGATGGTACCGAGTCGGCATTGCAGCACGGCTCCAAGACACTGATGGCGAGCCGTATCGTTGATGCAATCGTCACGTTCCTGGCAGGCTGTAGCAGCTAA
- Drug Resistance
- Mutations
- Function
- Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity). {ECO:0000250}.
- Family
-
HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily; PPC synthetase family
- GO
-
- FMN binding GO:0010181 molecular_function
- coenzyme A biosynthetic process GO:0015937 biological_process
- phosphopantothenoylcysteine decarboxylase activity GO:0004633 molecular_function
- phosphopantothenate--cysteine ligase activity GO:0004632 molecular_function
- plasma membrane GO:0005886 cellular_component
- pantothenate catabolic process GO:0015941 biological_process
- InterPro
Summary
- Name
- Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) [Includes: Phosphopantothenoylcysteine decarboxylase (PPCDC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (PPC synthetase) (PPCS) (Phosphopantothenoylcysteine synthase)]
- Family
- HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily; PPC synthetase family
- Protein Sequence
-
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
- Mass
- 43,577 Da
- Length
- 418 Aa
Rv1391 doesn't seem to be a targeted by any drug.
-
-
Pantothenate and CoA biosynthesis mtu00770
mtu00770PATHWAY_MAP mtu00770 Pantothenate and CoA biosynthesis
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.