fmt
- Type
- protein_coding
- Name
- fmt
- Locus Name
-
Rv1406
- Product
-
Probable methionyl-tRNA formyltransferase Fmt
- Functional Category
-
Information pathways
- Location
- 1582166..1583104 (+ strand)
- Gene Length
- 938 bp
- Nucleotides
-
TGCGCCTTGTCTTTGCCGGCACCCCCGAACCCGCGCTGGCCTCGCTGCGCAGGCTCATCGAATCGCCCAGTCACGACGTGATCGCCGTGTTGACCCGTCCGGATGCCGCCTCCGGCCGGCGGGGCAAGCCGCAGCCGTCACCGGTGGCCCGTGAGGCGGCAGAGCGCGGCATTCCGGTGCTGCGGCCATCGCGACCGAACTCGGCAGAGTTCGTCGCCGAACTGTCGGATCTGGCGCCAGAGTGCTGCGCCGTGGTTGCCTACGGAGCCCTGCTCGGCGGTCCCTTGCTGGCCGTGCCGCCGCATGGCTGGGTCAACCTGCACTTCTCGCTGCTGCCGGCCTGGCGTGGCGCGGCGCCGGTGCAGGCCGCCATCGCCGCGGGAGACACGATCACCGGAGCCACGACGTTCCAGATTGAGCCAAGCCTGGACTCGGGACCGATATACGGTGTCGTCACCGAGGTGATCCAGCCGACCGACACCGCGGGCGATCTACTTAAGCGACTGGCGGTATCGGGGGCAGCGCTGCTATCGACCACGCTGGATGGCATCGCCGATCAGCGGCTGACGCCGCGGCCGCAACCGGCAGACGGGGTCAGCGTGGCGCCGAAAATCACCGTAGCGAATGCCCGGGTGCGATGGGACTTGCCGGCGGCGGTCGTGGAGCGGCGGATCCGCGCCGTCACTCCCAACCCCGGCGCCTGGACGCTCATCGGTGACTTACGGGTCAAACTTGGACCGGTGCACCTCGACGCCGCTCACCGGCCATCGAAGCCCTTGCCGCCCGGTGGAATCCACGTGGAACGCACGAGCGTGTGGATCGGCACCGGCTCGGAACCGGTGCGGCTGGGCCAGATTCAGCCGCCCGGCAAGAAACTCATGAACGCGGCCGACTGGGCGCGGGGCGCACGGCTGGACCTGGCCGCACGGGCAACATGA
- Drug Resistance
- Mutations
- Function
- Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. {ECO:0000255|HAMAP-Rule:MF_00182}.
- Family
-
Fmt family
- GO
-
- conversion of methionyl-tRNA to N-formyl-methionyl-tRNA GO:0071951 biological_process
- cytosol GO:0005829 cellular_component
- methionyl-tRNA formyltransferase activity GO:0004479 molecular_function
- InterPro
Summary
- Name
- Methionyl-tRNA formyltransferase (EC 2.1.2.9)
- Family
- Fmt family
- Protein Sequence
-
MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQPSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAGDLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVERRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPVRLGQIQPPGKKLMNAADWARGARLDLAARAT
- Mass
- 32,692 Da
- Length
- 312 Aa
Rv1406 doesn't seem to be a targeted by any drug.
Rv1406 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.