ribA2
- Type
- protein_coding
- Name
- ribA2
- Locus Name
-
Rv1415
- Product
-
Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1590397..1591674 (+ strand)
- Gene Length
- 1277 bp
- Nucleotides
-
TGACGAGGTTGGACTCCGTCGAGCGGGCGGTTGCCGACATTGCGGCGGGTAAGGCCGTCATCGTCATCGACGACGAAGACCGGGAGAACGAGGGTGACCTGATCTTCGCCGCCGAGAAGGCAACGCCGGAGATGGTGGCCTTCATGGTCCGCTACACCTCCGGATACCTGTGCGTTCCGCTGGACGGTGCCATCTGCGACCGGCTGGGCCTGTTGCCCATGTACGCGGTGAACCAGGACAAGCACGGGACGGCATACACCGTCACAGTCGATGCACGGAATGGCATTGGAACTGGCATTTCGGCGTCCGATCGGGCTACCACCATGCGGTTGCTGGCCGATCCGACCAGTGTGGCCGACGATTTCACCCGCCCCGGTCACGTGGTCCCCTTGCGGGCCAAGGATGGTGGGGTTCTGCGCCGGCCCGGCCACACCGAGGCCGCCGTGGACCTGGCCCGGATGGCCGGGCTGCAACCCGCGGGGGCGATTTGCGAGATCGTCAGCCAAAAAGATGAGGGCTCGATGGCGCACACCGATGAATTGCGGGTGTTCGCCGATGAGCACGGTCTGGCGCTGATCACCATTGCTGACTTGATCGAATGGCGGCGCAAGCACGAGAAGCACATTGAGCGGGTCGCCGAGGCGCGGATTCCGACTCGTCATGGGGAGTTTCGCGCCATCGGCTACACCAGCATCTACGAGGACGTGGAACATGTCGCGCTGGTCCGCGGCGAGATCGCCGGGCCCAACGCCGACGGTGACGACGTGCTGGTCCGGGTGCATTCGGAGTGCTTGACCGGCGATGTGTTTGGGTCACGCCGCTGCGATTGCGGGCCTCAGCTGGACGCCGCGCTGGCGATGGTCGCCCGTGAGGGGCGCGGCGTGGTGCTGTACATGCGTGGCCACGAGGGCCGCGGCATCGGCCTGATGCACAAACTGCAGGCCTACCAACTGCAGGACGCCGGTGCCGACACCGTTGACGCCAATCTCAAGCTTGGACTACCTGCCGACGCAAGGGATTACGGGATCGGCGCACAGATCCTGGTCGATCTTGGGGTACGTTCGATGAGGCTGCTGACCAACAACCCGGCCAAGCGGGTGGGACTGGATGGATACGGATTGCACATCATCGAGCGCGTGCCGCTGCCGGTGCGGGCCAACGCGGAGAACATCCGTTACCTGATGACCAAGCGTGACAAATTGGGGCACGACTTGGCTGGGTTGGACGATTTTCACGAATCCGTGCATCTGCCCGGAGAATTCGGCGGTGCCTTGTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. {ECO:0000255|HAMAP-Rule:MF_01283}.; FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. {ECO:0000255|HAMAP-Rule:MF_01283}.
- Family
-
DHBP synthase family; GTP cyclohydrolase II family
- GO
-
- magnesium ion binding GO:0000287 molecular_function
- riboflavin biosynthetic process GO:0009231 biological_process
- GTP cyclohydrolase II activity GO:0003935 molecular_function
- 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0008686 molecular_function
- manganese ion binding GO:0030145 molecular_function
- extracellular region GO:0005576 cellular_component
- GTP binding GO:0005525 molecular_function
- cytosol GO:0005829 cellular_component
- zinc ion binding GO:0008270 molecular_function
- InterPro
Summary
- Name
- Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
- Family
- DHBP synthase family; GTP cyclohydrolase II family
- Protein Sequence
-
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPGEFGGAL
- Mass
- 46,017 Da
- Length
- 425 Aa
Rv1415 doesn't seem to be a targeted by any drug.
-
-
Folate biosynthesis mtu00790
mtu00790PATHWAY_MAP mtu00790 Folate biosynthesis
-
-
-
Riboflavin metabolism mtu00740
mtu00740PATHWAY_MAP mtu00740 Riboflavin metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.