Gene - combatTB X

uvrC

Type: protein_coding
Name: uvrC
Locus Name: Rv1420
Product: Probable excinuclease ABC (subunit C-nuclease) UvrC
Functional Category: Information pathways
Location: 1594042..1595982 (+ strand)
Gene Length: 1940 bp
Nucleotides: TGCCAGATCCCGCAACGTATCGCCCCGCGCCCGGGTCCATCCCGGTCGAGCCGGGCGTGTACCGATTCCGGGACCAGCATGGGCGAGTCATCTACGTCGGCAAGGCCAAGAGCCTGCGTAGCCGGCTGACGTCCTATTTTGCCGACGTGGCCAGCCTAGCGCCGCGGACCCGGCAGCTGGTGACCACCGCGGCCAAGGTCGAATGGACGGTCGTGGGGACCGAGGTTGAGGCACTGCAGCTGGAATACACCTGGATCAAGGAGTTCGATCCGCGATTCAACGTCCGCTACCGCGACGACAAGTCCTACCCTGTGCTGGCGGTCACCCTGGGCGAGGAATTTCCCCGGTTGATGGTCTATCGCGGTCCGCGGCGCAAGGGTGTGCGCTATTTCGGGCCGTACTCGCACGCGTGGGCAATCCGGGAAACGCTGGATCTGCTCACCCGGGTGTTTCCGGCGCGAACTTGCTCGGCGGGGGTGTTTAAGCGGCACAGGCAGATCGATCGTCCATGCCTGCTCGGCTACATCGACAAATGTTCCGCGCCGTGTATTGGCAGGGTCGATGCGGCCCAGCACCGCCAGATCGTGGCAGACTTCTGCGACTTTCTGTCCGGCAAGACCGACCGGTTCGCCCGCGCCTTGGAACAGCAAATGAACGCCGCGGCCGAGCAACTGGACTTCGAACGAGCGGCGCGGCTTCGCGACGACCTGTCCGCACTGAAGCGTGCCATGGAAAAGCAGGCCGTGGTGCTCGGGGACGGCACCGACGCCGACGTGGTGGCATTCGCCGACGACGAACTCGAGGCGGCGGTGCAAGTGTTCCACGTGCGCGGCGGACGGGTCCGCGGCCAGCGTGGCTGGATTGTCGAAAAGCCAGGAGAGCCAGGAGATTCCGGAATCCAGTTGGTCGAGCAATTCCTGACACAGTTCTACGGCGACCAGGCGGCGTTGGACGACGCCGCCGACGAATCCGCCAACCCGGTTCCCCGCGAGGTGCTGGTGCCCTGTTTGCCGTCCAACGCCGAGGAGCTGGCCAGCTGGCTGTCCGGCCTGCGCGGCTCAAGGGTCGTGCTGCGGGTGCCGCGCCGCGGGGACAAGCGGGCACTGGCCGAAACGGTGCACCGAAACGCAGAAGATGCACTGCAACAACACAAGCTGAAGCGGGCCAGCGATTTCAACGCCAGATCCGCTGCGCTGCAGAGCATTCAGGACTCGTTGGGCCTGGCAGACGCACCCTTGCGGATCGAGTGTGTCGACGTCAGCCATGTGCAGGGCACCGACGTGGTCGGGTCACTGGTGGTGTTCGAAGACGGCCTGCCGCGCAAGTCGGACTACCGCCACTTCGGGATCCGGGAAGCCGCAGGCCAGGGGCGCTCCGACGACGTGGCCTGTATTGCCGAGGTGACCCGGCGCCGCTTCCTGCGGCACCTGCGCGATCAGAGCGATCCGGATCTTCTTTCTCCGGAAAGGAAGTCGCGTAGATTCGCCTATCCGCCCAATCTGTACGTCGTCGACGGCGGCGCGCCGCAAGTCAACGCGGCCAGTGCGGTAATCGACGAACTCGGTGTTACCGACGTCGCGGTGATCGGCCTGGCCAAGCGGCTGGAAGAGGTATGGGTGCCGTCGGAGCCGGACCCGATTATCATGCCGCGCAACAGTGAGGGACTCTATCTGCTGCAGCGAGTGCGAGACGAGGCACACCGGTTCGCTATCACCTACCATCGCAGCAAGCGGTCGACGCGGATGACTGCCTCAGCGCTGGACTCGGTGCCGGGATTGGGGGAGCATCGCCGCAAAGCGCTGGTCACCCATTTCGGATCGATCGCTCGCCTCAAGGAGGCCACCGTCGACGAAATCACCGCTGTTCCCGGTATCGGCGTGGCCACGGCCACGGCCGTCCACGACGCACTGCGACCTGACTCATCGGGGGCCGCGCGATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-Rule:MF_00203}.

Family

UvrC family

GO

SOS response GO:0009432 biological_process
excinuclease repair complex GO:0009380 cellular_component
excinuclease ABC activity GO:0009381 molecular_function
cell wall GO:0005618 cellular_component
DNA binding GO:0003677 molecular_function
nucleotide-excision repair GO:0006289 biological_process
cellular response to DNA damage stimulus GO:0006974 biological_process
cytoplasm GO:0005737 cellular_component
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WFC5
GenBank: Rv1420
EnsemblBacteria: Rv1420
Mycobrowser: Rv1420

Summary

Name: UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C)
Family: UvrC family
Protein Sequence: MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSALKRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQSIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQSDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDSSGAAR
Mass: 71,614 Da
Length: 646 Aa

Rv1420 doesn't seem to be a targeted by any drug.

Nucleotide excision repair mtu03420
mtu03420
Genetic Information Processing; Replication and repair

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.