Gene - combatTB X

Rv1433

Type: protein_coding
Name: Rv1433
Locus Name: Rv1433
Product: Possible conserved exported protein
Functional Category: Cell wall and cell processes
Location: 1611434..1612249 (+ strand)
Gene Length: 815 bp
Nucleotides: TGCGGGCGGTTTTTGGGTGTGCTATTGCCGTCGTCGGGATCGCTGGGAGCGTGGTTGCGGGGCCGGCCGACATACACCTGGTGGCGGCGAAGCAGTCTTACGGGTTCGCCGTCGCGTCGGTGCTACCAACGCGCGGCCAGGTGGTGGGCGTGGCGCACCCCGTGGTGGTGACGTTCAGTGCGCCGATAACTAACCCAGCCAATCGGCACGCGGCCGAGCGCGCCGTTGAAGTCAAATCGACGCCCGCGATGACCGGCAAGTTCGAATGGCTCGACAACGACGTTGTGCAGTGGGTTCCCGACCGCTTCTGGCCGGCGCACAGCACGGTGGAGCTTTCGGTGGGCAGCCTGTCGAGCGATTTCAAGACGGGTCCCGCCGTCGTCGGGGTTGCCAGCATCTCCCAGCACACGTTCACCGTGAGTATCGACGGAGTCGAGGAGGGACCGCCGCCTCCGCTGCCGGCGCCGCACCACCGAGTGCACTTCGGCGAAGATGGGGTGATGCCGGCATCGATGGGTAGACCGGAATACCCGACGCCGGTCGGCTCCTACACTGTCTTGTCCAAGGAACGCTCGGTGATTATGGATTCGAGCAGCGTCGGCATCCCCGTCGACGATCCCGATGGTTACCGGCTTTCGGTGGATTATGCCGTCCGCATCACCAGCCGCGGCCTCTACGTGCATTCAGCCCCGTGGGCCCTTCCAGCACTGGGACTTGAAAATGTCAGCCACGGCTGCATAAGCCTGAGCCGCGAGGACGCAGAGTGGTATTACAACGCGGTCGACATTGGCGACCCGGTCATTGTGCAGGAATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Probable L,D-transpeptidase that may perform as-yet-unknown cross-linking reactions in M.tuberculosis. Is not able to generate 3->3 cross-links in peptidoglycan, using tetrapeptide stems as acyl donor substrates. May function in the anchoring of proteins to peptidoglycan. {ECO:0000269|PubMed:24041897}.

Family

Unknown

GO

peptidoglycan L,D-transpeptidase activity GO:0071972 molecular_function
cell wall organization GO:0071555 biological_process
peptidoglycan-protein cross-linking GO:0018104 biological_process
regulation of cell shape GO:0008360 biological_process
transferase activity, transferring acyl groups GO:0016746 molecular_function

InterPro

UniProt: O06825
GenBank: Rv1433
EnsemblBacteria: Rv1433
Mycobrowser: Rv1433

Summary

Name: Probable L,D-transpeptidase 3 (LDT 3) (EC 2.3.2.-) (Ldt(Mt3))
Family: Unknown
Protein Sequence: MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTRGQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFWPAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFGEDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITSRGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE
Mass: 28,701 Da
Length: 271 Aa

Rv1433 doesn't seem to be a targeted by any drug.

Rv1433 doesn't seem to be involved in any pathway.

In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.: Antimicrob Agents Chemother. 2013 Dec;57(12):5940-5. doi: 10.1128/AAC.01663-13. Epub 2013 Sep 16.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.