Gene - combatTB X

zwf2

Type: protein_coding
Name: zwf2
Locus Name: Rv1447c
Product: Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Functional Category: Intermediary metabolism and respiration
Location: 1625418..1626962 (- strand)
Gene Length: 1544 bp
Nucleotides: ATGAAACCGGCCCACGCCGCGGCGTCGTGGCGCAACCCGCTACGAGACAAGCGGGACAAGCGATTACCCAGAATCGCCGGCCCGTGCGGCATGGTGATTTTCGGCGTCACCGGCGACCTGGCCCGCAAGAAGGTGATGCCGGCCGTCTACGATTTGGCCAACCGCGGCCTGCTGCCGCCCACATTCTCGCTGGTGGGGTTTGCCCGCCGAGACTGGAGCACCCAGGATTTCGGTCAAGTGGTGTACAACGCCGTCCAAGAGCACTGCCGAACACCGTTTCGGCAACAGAACTGGGACCGGCTGGCCGAGGGATTCCGTTTTGTGCCAGGCACTTTCGACGACGACGACGCGTTCGCCCAACTCGCCGAGACGCTGGAGAAGCTCGACGCCGAGCGCGGCACCGGCGGCAACCACGCCTTCTACCTGGCGATCCCGCCCAAATCCTTCCCGGTGGTGTGTGAGCAGCTGCACAAGTCCGGCCTGGCCCGCCCGCAAGGCGACCGGTGGAGCCGAGTCGTGATAGAGAAGCCGTTCGGCCACGACCTGGCCAGCGCACGCGAGCTGAACAAGGCGGTCAACGCGGTCTTCCCGGAGGAAGCGGTCTTCCGCATCGACCACTACCTGGGCAAAGAGACGGTGCAGAACATCCTGGCGCTGCGGTTCGCCAACCAGCTGTTCGACCCGATCTGGAATGCGCACTACGTCGACCACGTACAGATCACCATGGCCGAAGACATCGGCCTGGGCGGGCGCGCGGGCTATTACGACGGCATCGGCGCGGCCCGCGATGTCATCCAGAACCATCTCATGCAGCTGCTGGCGCTGACCGCGATGGAGGAGCCGGTCAGCTTCCACCCGGCAGCGTTGCAGGCCGAGAAGATCAAGGTGCTCTCGGCCACCCGCCTTGCCGAGCCACTCGACCAGACCACCAGCCGCGGCCAGTACGCCGCCGGCTGGCAAGGCGGGGAGAAGGTGGTTGGGCTGCTCGACGAGGAGGGGTTCGCCGAGGACTCCACCACCGAAACCTTCGCCGCTATCACCCTGGAAGTCGATACGCGCCGGTGGGCCGGCGTGCCGTTCTATCTGCGAACGGGAAAACGATTGGGCCGCCGGGTGACCGAGATCGCTCTGGTCTTCAGGCGGGCGCCGCATCTGCCGTTCGACGCCACCATGACCGACGAGCTGGGCACCAACGCGATGGTCATCCGCGTGCAGCCCGACGAAGGTGTCACATTGCGGTTCGGCTCCAAGGTGCCGGGCACCGCCATGGAAGTCCGCGACGTCAACATGGACTTCTCCTACGGCTCGGCATTCGCCGAAGATTCACCGGAGGCCTACGAGCGGCTCATCCTCGACGTCCTGCTCGGCGAGCCCTCGCTGTTTCCGGTCAACGCGGAGGTCGAACTGGCGTGGGAGATCCTCGATCCAGCGTTGGAACATTGGGCGGCACACGGGACGCCCGACGCCTACGAGGCAGGTACCTGGGGTCCGGAATCATCCTTGGAGATGCTGCGCCGCACCGGCCGGGAATGGCGGCGGCCATA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. {ECO:0000255|HAMAP-Rule:MF_00966}.

Family

Glucose-6-phosphate dehydrogenase family

GO

pentose-phosphate shunt GO:0006098 biological_process
glucose metabolic process GO:0006006 biological_process
plasma membrane GO:0005886 cellular_component
NADP binding GO:0050661 molecular_function
glucose-6-phosphate dehydrogenase activity GO:0004345 molecular_function

InterPro

UniProt: P9WN73
GenBank: Rv1447c
EnsemblBacteria: Rv1447c
Mycobrowser: Rv1447c

Summary

Name: Glucose-6-phosphate 1-dehydrogenase 2 (G6PD 2) (EC 1.1.1.49)
Family: Glucose-6-phosphate dehydrogenase family
Protein Sequence: MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
Mass: 57,343 Da
Length: 514 Aa

Rv1447c doesn't seem to be a targeted by any drug.

Glutathione metabolism mtu00480
mtu00480
PATHWAY_MAP mtu00480 Glutathione metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.