Gene - combatTB X

Rv1461

Type: protein_coding
Name: Rv1461
Locus Name: Rv1461
Product: Conserved protein
Functional Category: Conserved hypotheticals
Location: 1646989..1649529 (+ strand)
Gene Length: 2540 bp
Nucleotides: TGACACTCACCCCAGAGGCCAGCAAGAGCGTTGCCCAGCCCCCGACCCAGGCTCCCCTGACCCAGGAAGAGGCGATCGCGTCGCTGGGCCGGTACGGCTACGGCTGGGCGGACTCCGACGTCGCGGGTGCCAACGCGCAGCGCGGGCTTTCCGAGGCGGTGGTCCGCGACATCTCCGCGAAGAAGAACGAGCCCGATTGGATGCTGCAGTCGCGGCTGAAGGCGCTGCGCATTTTCGACCGCAAGCCCATTCCGAAGTGGGGCTCCAACCTCGATGGCATCGATTTCGACAACATCAAGTACTTCGTGCGCTCCACCGAGAAGCAGGCCGCGAGCTGGGATGATTTGCCAGAGGACATCCGCAACACCTACGACCGGTTGGGAATCCCGGAGGCCGAGAAGCAGAGATTAGTAGCTGGAGTAGCCGCACAATACGAAAGTGAAGTTGTATATCACCAGATCAGAGAGGATCTGGAGGCTCAAGGAGTCATATTTTTAGACACTGATACTGGTTTGCGAGAACACCCGGATATTTTCAAGGAATATTTCGGTACAGTAATCCCTGCCGGCGATAATAAGTTTTCTGCATTGAATACTGCAGTTTGGAGTGGTGGGTCCTTTATTTACGTCCCGCCCGGTGTTCACGTCGACATTCCGCTGCAGGCCTACTTCCGAATCAACACCGAGAACATGGGCCAGTTCGAGCGGACGCTGATCATCGCCGATGAGGGCTCTTACGTGCACTACGTAGAGGGCTGCCTGCCCGCCGGCGAGCTCATCACGACCGCCGACGGCGATTTGCGGCCCATCGAGTCGATTCGCGTCGGTGACTTCGTCACCGGCCACGACGGGCGGCCACACCGCGTCACCGCTGTACAGGTGCGTGACCTCGATGGCGAGCTGTTCACCTTCACACCGATGTCGCCTGCCAACGCATTCTCTGTCACCGCCGAGCACCCCCTTCTCGCTATTCCCCGCGACGAGGTGCGTGTTATGCGGAAGGAACGCAATGGGTGGAAGGCTGAAGTCAACAGCACCAAGCTGCGTAGCGCCGAGCCGCGATGGATCGCGGCGAAGGATGTGGCCGAGGGTGACTTCCTGATCTACCCCAAGCCGAAGCCGATCCCCCACAGGACGGTTTTGCCGCTCGAGTTTGCGCGCCTGGCGGGCTACTACCTGGCGGAGGGTCACGCGTGTCTCACCAATGGCTGTGAGTCGCTGATCTTCTCGTTCCACAGCGATGAGTTCGAGTACGTCGAGGATGTGCGCCAAGCGTGCAAGTCGCTGTACGAGAAGTCGGGATCGGTATTGATCGAGGAGCACAAGCATTCGGCGCGCGTCACCGTGTACACGAAGGCGGGCTATGCGGCGATGCGCGACAACGTCGGCATTGGATCGTCGAATAAGAAGCTGTCGGATCTGTTGATGCGTCAAGACGAGACGTTCTTGCGTGAGCTGGTCGACGCCTATGTGAATGGAGACGGCAACGTCACGCGCCGTAACGGGGCGGTGTGGAAGCGGGTACATACGACATCGCGCCTCTGGGCGTTCCAGTTGCAGTCCATCCTGGCGCGTCTGGGTCACTACGCCACTGTTGAACTGCGCCGACCGGGCGGCCCTGGTGTGATCATGGGCCGCAACGTCGTTCGCAAGGACATCTACCAGGTGCAGTGGACCGAGGGCGGCCGCGGACCGAAGCAGGCCCGCGACTGCGGCGACTACTTTGCGGTGCCAATCAAGAAGCGAGCGGTCCGCGAAGCACATGAGCCCGTCTACAACCTCGATGTCGAGAATCCGGACAGCTACCTCGCCTACGGGTTCGCCGTGCACAACTGCACCGCACCGATCTACAAATCGGATTCATTGCACTCAGCGGTGGTCGAGATCATCGTGAAACCCCATGCGCGCGTGCGTTACACCACCATCCAGAACTGGTCGAACAACGTCTACAACCTGGTCACCAAGCGGGCCCGCGCCGAAGCCGGGGCCACCATGGAGTGGATCGACGGCAACATCGGGTCCAAGGTGACCATGAAGTACCCGGCGGTCTGGATGACCGGCGAGCACGCCAAGGGCGAAGTGCTCTCGGTGGCGTTCGCCGGCGAAGACCAGCACCAGGACACCGGCGCCAAGATGCTGCACCTGGCGCCGAACACGTCGAGCAACATCGTGTCCAAGTCGGTGGCCCGCGGCGGCGGCCGCACCTCCTACCGTGGCCTGGTGCAGGTCAACAAGGGGGCGCATGGGTCGCGGTCCAGCGTGAAATGCGATGCGCTGCTGGTGGATACGGTCAGCCGCAGCGACACCTACCCCTACGTCGACATCCGCGAGGACGACGTCACCATGGGCCACGAGGCCACCGTGTCCAAGGTCAGCGAGAACCAGCTGTTCTACCTGATGAGCCGCGGGCTGACCGAGGACGAGGCGATGGCGATGGTGGTGCGCGGCTTCGTCGAGCCGATCGCCAAGGAGCTGCCGATGGAGTACGCGCTGGAGCTCAACCGGCTGATCGAGCTGCAGATGGAGGGCGCGGTCGGATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

UPF0051 (ycf24) family

GO

cytosol GO:0005829 cellular_component
endonuclease activity GO:0004519 molecular_function
intein-mediated protein splicing GO:0016539 biological_process
iron-sulfur cluster assembly GO:0016226 biological_process
intron homing GO:0006314 biological_process

InterPro

UniProt: P9WFP7
GenBank: Rv1461
EnsemblBacteria: Rv1461
Mycobrowser: Rv1461

Summary

Name: UPF0051 protein Rv1461 [Cleaved into: Endonuclease PI-MtuHIIP (EC 3.1.-.-) (Mtu pps1 intein)]
Family: UPF0051 (ycf24) family
Protein Sequence: MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
Mass: 94,171 Da
Length: 846 Aa

Rv1461 doesn't seem to be a targeted by any drug.

Rv1461 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.