Gene - combatTB X

Rv1473

Type: protein_coding
Name: Rv1473
Locus Name: Rv1473
Product: Probable macrolide-transport ATP-binding protein ABC transporter
Functional Category: Cell wall and cell processes
Location: 1660656..1662284 (+ strand)
Gene Length: 1628 bp
Nucleotides: TGATCACAGCTACGGACCTCGAGGTCCGCGCTGGCGCGCGCATCCTGCTCGCACCCGACGGCCCCGACCTGCGTGTGCAGCCCGGCGATCGTATCGGGCTGGTCGGACGTAACGGTGCCGGCAAGACCACCACGCTGCGCATTCTGGCGGGGGAGGTCGAACCCTATGCCGGGTCGGTTACCCGTGCCGGCGAAATCGGCTACCTGCCACAGGATCCCAAAGTTGGCGATCTCGACGTGCTGGCCCGTGACCGGGTGCTGTCCGCCCGCGGACTGGACGTCCTGCTCACTGATCTGGAGAAGCAGCAGGCGTTGATGGCCGAGGTCGCCGACGAGGACGAGCGTGACCGCGCCATCCGCCGTTACGGTCAGCTCGAGGAGCGATTCGTCGCGCTGGGCGGCTATGGCGCCGAAAGCGAAGCCGGCCGCATCTGCGCCAGCCTAGGCTTGCCCGAGCGGGTGCTGACCCAGCGGCTGCGTACCCTTTCCGGAGGTCAGCGCCGCCGGGTGGAACTAGCCCGCATTTTGTTCGCCGCGTCCGAGAGTGGCGCTGGAAATTCCACCACCTTGTTGCTCGACGAGCCGACTAACCACCTCGACGCTGATTCGCTGGGCTGGCTGCGGGACTTCCTGCGCTTGCATACGGGCGGGCTGGTGGTCATCAGCCACAACGTGGACCTGGTGGCCGATGTCGTCAATAAAGTGTGGTTCCTGGATGCCGTGCGCGGCCAGGTCGATGTTTACAACATGGGCTGGCAGCGCTACGTCGACGCTCGGGCCACCGACGAGCAACGTCGCATCCGGGAACGCGCTAACGCCGAACGCAAGGCGGCCGCGCTGCGTGCACAGGCCGCCAAGTTGGGCGCCAAGGCCACCAAAGCCGTTGCGGCCCAGAACATGTTGCGCCGCGCCGATCGGATGATGGCCGCACTCGACGAGGAGCGAGTCGCCGACAAGGTGGCCCGGATCAAGTTCCCCACCCCGGCGGCGTGTGGACGCACACCGCTGGTGGCCAACGGTCTGGGCAAGACGTATGGCTCGCTGGAAGTCTTCACCGGTGTCGACTTGGCCATCGACCGCGGCTCGCGGGTGGTCATACTCGGACTCAACGGTGCCGGCAAGACCACGCTGCTGCGATTGCTGGCCGGTGTCGAGCAGCCCGACACCGGAGTGCTGGAACCCGGATACGGTTTACGGATCGGCTATTTCGCGCAGGAGCACGACACGCTCGACAACGATGCCACCGTTTGGGAGAACGTCCGGCACGCGGCACCGGATGCCGGCGAACAGGACCTGCGCGGCCTGCTGGGTGCGTTCATGTTCACCGGTCCGCAGCTCGAGCAGCCGGCCGGCACGCTCTCCGGCGGTGAGAAGACCCGGCTCGCGCTGGCCGGCTTGGTGGCCTCCACCGCGAATGTGCTGCTGCTCGATGAACCGACCAACAATCTCGATCCGGCCTCGCGCGAGCAGGTGCTCGACGCGCTGCGCAGCTACCGAGGTGCGGTGGTGCTGGTGACGCATGATCCCGGGGCGGCCGCGGCGCTCGGTCCCCAACGGGTGGTGCTGTTGCCCGACGGCACCGAGGACTACTGGTCCGACGAGTATCGAGATCTCATCGAGCTGGCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

response to antibiotic GO:0046677 biological_process
cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: O53164
GenBank: Rv1473
EnsemblBacteria: Rv1473
Mycobrowser: Rv1473

Summary

Name: Probable macrolide-transport ATP-binding protein ABC transporter
Family: Unknown
Protein Sequence: MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLSGGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERKAAALRAQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRTPLVANGLGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGPQRVVLLPDGTEDYWSDEYRDLIELA
Mass: 58,424 Da
Length: 542 Aa

Rv1473 doesn't seem to be a targeted by any drug.

Rv1473 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.