Gene - combatTB X

Rv1474c

Type: protein_coding
Name: Rv1474c
Locus Name: Rv1474c
Product: Probable transcriptional regulatory protein
Functional Category: Regulatory proteins
Location: 1662641..1663204 (- strand)
Gene Length: 563 bp
Nucleotides: GTGCCCAAGGTCAGCGAGGACCATCTGGCGGCTCGCCGCCGTCAGATCCTCGACGGTGCGCGCCGTTGCTTTGCCGAATACGGCTATGACAAGGCCACGGTCCGGCGCCTGGAACAGGCAATCGGGATGTCGCGCGGTGCGATCTTTCACCACTTCCGCGACAAGGACGCGCTGTTTTTCGCGCTGGCGCGCGAGGATACCGAGCGAATGGCGGCTGTAGCATCCCGCGAAGGCCTCATCGGTGTGATGCGCGACATGCTTGCCGCGCCCGACCAGTTCGACTGGCTGGCCACCAGGTTGGAGATCGCACGCAAGCTGCGCAACGACCCTGACTTCAGCCGCGGCTGGGCGGAGCGCTCCGCGGAATTGGCGGCGGCGACCACCGATCGGCTGCGCCGGCAAAAGCAGGCTAACCGAGTGCGTGACGATGTGCCTAGCGACGTTTTGCGGTGCTACCTGGACCTGGTGCTCGACGGATTGCTGGCCCGGCTGGCCTCCGGCGAAGACCCGCAGCGGCTAGCCGCCGTCCTCGACCTGGTGGAGAACTCGGTGCGTCGGTCTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Represses the expression of the aconitase gene acn and its own expression, in an iron-responsive manner. Binds to the inverted repeat element present in the upstream region of acn (Rv1475c)-Rv1474c operon. Preferentially binds to major groove of the DNA. {ECO:0000269|PubMed:28237036}.

Family

Unknown

GO

cell wall GO:0005618 cellular_component
DNA binding GO:0003677 molecular_function

InterPro

UniProt: O53165
GenBank: Rv1474c
EnsemblBacteria: Rv1474c
Mycobrowser: Rv1474c

Summary

Name: HTH-type transcriptional repressor Rv1474c
Family: Unknown
Protein Sequence: MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMSRGAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEIARKLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGLLARLASGEDPQRLAAVLDLVENSVRRS
Mass: 21,269 Da
Length: 187 Aa

Rv1474c doesn't seem to be a targeted by any drug.

Rv1474c doesn't seem to be involved in any pathway.

Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.: Tuberculosis (Edinb). 2017 Mar;103:71-82. doi: 10.1016/j.tube.2017.01.003. Epub 2017 Jan 17.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.