Gene - combatTB X

Type: protein_coding
Name: Rv1500
Locus Name: Rv1500
Product: Probable glycosyltransferase
Functional Category: Intermediary metabolism and respiration
Location: 1690850..1691878 (+ strand)
Gene Length: 1028 bp
Nucleotides: TGCGCCTCTCGATCGTAACGACTATGTACATGTCAGAGCCTTACGTGCTGGAGTTCTACAGGAGAGCGCGCGCGGCGGCGGACAAAATCACGCCTGACGTCGAGATCATCTTCGTGGATGACGGCTCGCCGGACGCAGCGCTCCAGCAGGCCGTCTCGCTGCTCGACAGCGACCCCTGTGTTCGGGTAATTCAGCTTTCGCGAAATTTCGGCCACCACAAAGCGATGATGACCGGCCTGGCGCACGCCACGGGGGATCTCGTCTTTCTGATCGACTCAGACTTGGAAGAGGACCCGGCTCTCCTAGAGCCGTTCTATGAAAAGCTGATCTCGACGGGCGCCGACGTAGTATTTGGTTGCCACGCGCGGCGGCCCGGCGGTTGGTTGAGGAATTTCGGACCGAAAATCCATTATCGGGCGTCCGCCCTGCTGTGTGACCCCCCGCTTCATGAAAATACTCTCACCGTGCGGCTGATGACAGCCGACTATGTACGCAGCTTGGTCCAGCACCAGGAGCGTGAACTTTCGATTGCCGGTCTGTGGCAGATTACTGGTTTTTACCAGGTGCCCATGTCCGTAAACAAGGCATGGAAAGGAACGACCACATACACGTTTAGGCGTAAAGTAGCGACACTGGTCGACAATGTCACTTCATTTAGCAACAAACCTCTAGTCTTCATTTTCTATCTTGGTGCGGCCATTTTTATTATTTCAAGCTCGGCCGCGGGCTATCTGATCATCGATCGAATTTTCTTTCGCGCTCTGCAAGCGGGGTGGGCATCCGTGATCGTATCCATCTGGATGCTGGGGGGTGTGACGATTTTCTGCATAGGGCTGGTCGGAATTTATGTATCCAAAGTCTTCATCGAAACTAAGCAGCGGCCATACACAATTATCCGAAGAATCTACGGTTCGGATTTAACAACCCGGGAGCCATCCTCTCTGAAGACCGCCTTCCCGGCCGCGCACCTGTCGAACGGGAAACGCGTCACATCAGAGCCAGAGGGATTGGCAACTGGCAACAGGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May play only a redundant role in maintaining cell wall viability and bacterial virulence. {ECO:0000269|PubMed:18585090}.

Family

Glycosyltransferase 2 family

GO

InterPro

Summary

Name: Putative glycosyltransferases (EC 2.4.-.-)
Family: Glycosyltransferase 2 family
Protein Sequence: MRLSIVTTMYMSEPYVLEFYRRARAAADKITPDVEIIFVDDGSPDAALQQAVSLLDSDPCVRVIQLSRNFGHHKAMMTGLAHATGDLVFLIDSDLEEDPALLEPFYEKLISTGADVVFGCHARRPGGWLRNFGPKIHYRASALLCDPPLHENTLTVRLMTADYVRSLVQHQERELSIAGLWQITGFYQVPMSVNKAWKGTTTYTFRRKVATLVDNVTSFSNKPLVFIFYLGAAIFIISSSAAGYLIIDRIFFRALQAGWASVIVSIWMLGGVTIFCIGLVGIYVSKVFIETKQRPYTIIRRIYGSDLTTREPSSLKTAFPAAHLSNGKRVTSEPEGLATGNR
Mass: 38,095 Da
Length: 342 Aa

Rv1500 doesn't seem to be a targeted by any drug.

Rv1500 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
In vitro and in vivo characterization of a Mycobacterium tuberculosis mutant deficient in glycosyltransferase Rv1500.: Int J Med Microbiol. 2008 Oct;298(7-8):645-55. doi: 10.1016/j.ijmm.2008.03.010. Epub 2008 Jun 26.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
PimF, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan.: J Biol Chem. 2004 Apr 30;279(18):18824-33. doi: 10.1074/jbc.M400791200. Epub 2004 Feb 11.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.