Gene - combatTB X

mmpL12

Type: protein_coding
Name: mmpL12
Locus Name: Rv1522c
Product: Probable conserved transmembrane transport protein MmpL12
Functional Category: Cell wall and cell processes
Location: 1714172..1717612 (- strand)
Gene Length: 3440 bp
Nucleotides: GTGGCAAGGCATGACGAGGCCAAAGCCGGGGGACTGTTCGACCGTATCGGCAACTTCGTGGTGCGATGGCCGCTGATCGTCATTGGGTGCTGGATCGCGGTGGCGGCCGCGCTGACGCTGTTGCTCCCAACGCTGCAGGCGCAAGCCGCAAAGCGCGAGCAAGCTCCCCTGCCGCCCGGGGCCCCATCGATGGTCCTGCAAAAGGAGATGAGCGCGGCTTTCCAGGAAAAAATTGAGACCTCCGCCCTCCTTTTGGTCCTCTTGACCAACGAGAACGGGCTGGGACCCGCCGACGAGGCCGTCTACCGAAAACTGATCGAAAACCTGCGGGCGGACACGCAGGACAAAATATCGGTTCAGGATTTTCTCGCCGTCCCCGAAATGAAGGAGCTGTTGGCCAGCAAGGACAACAAGGCTTGGAACCTGCCCATCACGTTCGCGGGCGATGCCGCGTCGCCTGAGACACAAGCGGCGTTCAAACGCGTCGCCGCGATCGTCAAGCAAACAGTCGCGGGAACCAGCCTGACCGTCCACCTCAGCGGTCCGATCGCCACGGTCGCCGACCTGACGGAGCTCGGCGAGAAAGATGTGCGGATCATCGAGATCGGCACCGCGGTCAGCGTGCTGATCATCCTGATCCTCGTCTATCGGAACCTGGTGACCATGCTGGTGCCGCTGGCCACCATCGGAGCGTCGGTGGTCACTGCGCAGGGCACGTTGTCCGGGCTCGCCGAGTTCGGCCTGGCCGTGAACATGCAGGCGATCGTCTTTATGAGCGCGGTCATGATCGGGGCGGGAACCGATTACGCCGTCTTTCTGATAAGTCGCTATCACGACTATGTGCGCCACGGCGAAAAATCGGACATGGCGGTCAAGAAGGCGTTGATGTCCATCGGCAAGGTGATCACCGCATCGGCGGCCACCGTCGCCGTCACATTTCTGGCGATGGTGTTCACCAAACTGGAAGTGTTTTCGGCGGTGGGCCCGGCAATTGCGGTTGCCATCACGGTGTCGCTGCTGGGTGCGGTCACCCTGCTGCCCGCCATCCTGACACTCACCGGACGGCGGGGCTGGATCAAGCCGCGACGCGACCTGACCAGTCGAATGTGGCGGCGTTCGGGTGTTCGCATCGTGCGTCGGTCCACCATCCACCTGGTCGGCAGTCTCATTGTGCTGGTCGCCCTGGCCGGCTGCACGCTGCTGATCCGATTCAACTACGACGATCTCAAGACGGTGCCGCAGCACGTCGAAAGCGTCAAAGGATACGAGGCGATGAACCGCCATTTCCCGATGAACGCGATGACTCCGATGGTGCTGTTCATCAAATCCCCCCGAGACCTGCGGACACCCGGCGCGCTTGCCGACATCGAGATGATGTCCCGCGAGATAGCAGAATTGCCCAACATCGTGATGGTGCGGGGCTTGACCCGACCGAACGGGGAACCTCTGAAGGAGACCAAGGTCTCGTTTCAGGCTGGTGAAGTGGGCGGCAAGCTCGACGAAGCGACCACCCTGCTCGAAGAGCACGGAGGCGAGCTGGACCAGCTGACCGGCGGTGCGCACCAGTTGGCCGACGCCCTCGCCCAAATACGCAACGAAATCAATGGGGCCGTGGCCAGCTCGAGCGGGATAGTCAACACCCTGCAGGCCATGATGGACCTGATGGGCGGCGACAAGACCATCCGACAACTGGAAAATGCGTCCCAATATGTCGGGCGCATGCGGGCTCTGGGGGACAATCTGAGCGGGACCGTCACCGATGCCGAACAAATCGCCACTTGGGCCAGCCCTATGGTCAACGCCCTCAACTCCAGCCCGGTGTGTAACAGCGATCCCGCCTGTCGGACGTCGCGCGCACAGTTGGCGGCGATTGTCCAGGCGCAGGACGACGGCCTGCTCAGGTCCATCAGAGCGCTAGCCGTCACCCTGCAACAGACGCAGGAATACCAGACACTCGCCCGGACGGTGAGCACACTGGACGGGCAACTGAAGCAAGTCGTCAGCACCCTCAAAGCGGTCGACGGCCTACCCACCAAATTGGCTCAAATGCAGCAAGGAGCCAACGCTCTCGCCGACGGCAGCGCAGCGCTGGCGGCAGGCGTGCAGGAATTGGTCGATCAGGTCAAAAAGATGGGCTCAGGGCTCAACGAGGCCGCCGACTTCCTGTTGGGGATCAAGCGGGATGCGGACAAGCCGTCAATGGCGGGCTTCAACATTCCACCGCAGATTTTTTCGAGGGACGAGTTCAAGAAGGGCGCCCAGATTTTCCTGTCGGCCGATGGTCATGCGGCGCGGTACTTCGTGCAGAGCGCGCTGAATCCGGCCACCACCGAGGCGATGGATCAGGTCAACGATATCCTCCGTGTTGCGGATTCCGCGCGACCGAATACCGAACTCGAGGATGCCACGATAGGTCTGGCGGGGGTTCCGACTGCGCTGCGGGATATCCGCGACTACTACAACAGCGATATGAAATTCATCGTCATTGCGACGATCGTTATCGTATTCTTGATTCTCGTCATTCTGCTGCGCGCACTTGTGGCTCCGATATATCTGATAGGCTCGGTGCTGATTTCTTACTTGTCGGCCCTAGGCATAGGAACTCTCGTTTTCCAATTGATACTGGGCCAGGAAATGCATTGGAGCCTGCCGGGACTGTCCTTCATATTATTGGTTGCCATCGGCGCTGACTACAACATGCTGCTCATTTCACGCATCCGCGACGAATCACCACACGGTATACGCATCGGCGTCATCCGAACCGTGGGCTCCACCGGTGGTGTTATCACCTCGGCGGGTCTCATCTTCGCCGCGTCGATGTTCGGTCTGGTGGGCGCGAGCATCAACACGATGGCTCAGGCCGGTTTCACCATCGGCATCGGGATCGTGCTGGACACCTTCCTGGTCCGCACGGTCACGGTGCCGGCCTTGACCACGATGATTGGCCGGGCAAACTGGTGGCCGTCCGAGCTGGGACGCGACCCATCCACGCCGCCGACCAAAGCCGATCGGTGGCTGCGGCGGGTGAAAGGCCACCGACGCAAGGCCCCGATCCCGGCGCCCAAGCCGCCCCACACCAAGGTCGTCCGCAACACCAACGGGCACGCAAGCAAGGCGGCAACCAAGTCGGTTCCCAACGGCAAGCCCGCTGACCTAGCCGAAGGCAACGGGGAGTACCTGATCGACCACCTGCGCAGACATTCGCTTCCGCTGTTCGGCTATGCCGCCATGCCGGCCTACGATGTCGTGGATGGCGTGTCGAAACCCAACGGCGACGGCGCCCACATCGGTAAAGAACCCGTCGACCATCTACTCGGCCACTCGCTGCCGCTGTTCGGTCTTGCCGGCCTACCGAGCTACGACCGTTGGGATGACACGTCTATCGGCGAACCCGCAGTCGGTCACGCGGGGTCAAAGCCCGACGCGAAGCTGAGCACCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily

GO

cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
response to host immune response GO:0052572 biological_process
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WJT7
GenBank: Rv1522c
EnsemblBacteria: Rv1522c
Mycobrowser: Rv1522c

Summary

Name: Probable transport protein MmpL12
Family: Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily
Protein Sequence: MARHDEAKAGGLFDRIGNFVVRWPLIVIGCWIAVAAALTLLLPTLQAQAAKREQAPLPPGAPSMVLQKEMSAAFQEKIETSALLLVLLTNENGLGPADEAVYRKLIENLRADTQDKISVQDFLAVPEMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVAAIVKQTVAGTSLTVHLSGPIATVADLTELGEKDVRIIEIGTAVSVLIILILVYRNLVTMLVPLATIGASVVTAQGTLSGLAEFGLAVNMQAIVFMSAVMIGAGTDYAVFLISRYHDYVRHGEKSDMAVKKALMSIGKVITASAATVAVTFLAMVFTKLEVFSAVGPAIAVAITVSLLGAVTLLPAILTLTGRRGWIKPRRDLTSRMWRRSGVRIVRRSTIHLVGSLIVLVALAGCTLLIRFNYDDLKTVPQHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEMMSREIAELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEEHGGELDQLTGGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKTIRQLENASQYVGRMRALGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDPACRTSRAQLAAIVQAQDDGLLRSIRALAVTLQQTQEYQTLARTVSTLDGQLKQVVSTLKAVDGLPTKLAQMQQGANALADGSAALAAGVQELVDQVKKMGSGLNEAADFLLGIKRDADKPSMAGFNIPPQIFSRDEFKKGAQIFLSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTELEDATIGLAGVPTALRDIRDYYNSDMKFIVIATIVIVFLILVILLRALVAPIYLIGSVLISYLSALGIGTLVFQLILGQEMHWSLPGLSFILLVAIGADYNMLLISRIRDESPHGIRIGVIRTVGSTGGVITSAGLIFAASMFGLVGASINTMAQAGFTIGIGIVLDTFLVRTVTVPALTTMIGRANWWPSELGRDPSTPPTKADRWLRRVKGHRRKAPIPAPKPPHTKVVRNTNGHASKAATKSVPNGKPADLAEGNGEYLIDHLRRHSLPLFGYAAMPAYDVVDGVSKPNGDGAHIGKEPVDHLLGHSLPLFGLAGLPSYDRWDDTSIGEPAVGHAGSKPDAKLST
Mass: 122,430 Da
Length: 1146 Aa

Rv1522c doesn't seem to be a targeted by any drug.

Rv1522c doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.