dinX
- Type
- protein_coding
- Name
- dinX
- Locus Name
-
Rv1537
- Product
-
Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed))
- Functional Category
-
Information pathways
- Location
- 1739856..1741247 (+ strand)
- Gene Length
- 1391 bp
- Nucleotides
-
TGCTGCACCTGGACATGGATGCGTTTTTCGCCTCGGTCGAACAGCTCACCCGGCCGACCCTGCGGGGGCGGCCGGTGCTGGTTGGCGGGCTGGGTGGGCGAGGTGTGGTGGCCGGCGCGAGCTATGAAGCGCGGGCCTACGGTGCCCGATCGGCCATGCCGATGCATCAGGCCCGCAGGCTGATCGGGGTGACGGCCGTGGTGTTGCCGCCACGCGGGGTGGTGTACGGGATCGCCAGCCGCCGGGTATTCGACACCGTGCGCGGCCTGGTGCCCGTCGTCGAACAGCTTTCTTTCGATGAAGCGTTCGCCGAACCGCCCCAACTCGCCGGGGCAGTGGCCGAGGACGTCGAGACGTTCTGCGAACGGTTGCGGCGACGGGTGCGCGACGAGACCGGCCTGATTGCCTCGGTCGGAGCGGGCTCGGGCAAGCAGATCGCCAAGATTGCTTCTGGTCTGGCCAAACCCGACGGCATTCGGGTAGTCCGGCACGCTGAAGAGCAAGCGCTTCTCAGCGGATTGCCGGTACGACGGCTGTGGGGCATCGGCCCGGTCGCCGAGGAAAAGCTGCATCGGCTCGGCATCGAGACGATCGGGCAGCTGGCCGCGCTGAGCGATGCCGAGGCGGCCAACATCCTAGGCGCGACGATTGGGCCCGCGCTGCACCGGCTGGCCCGTGGCATCGACGACCGCCCAGTGGTGGAGCGCGCCGAAGCCAAGCAAATCAGCGCCGAGTCCACGTTCGCCGTCGATCTGACCACCATGGAGCAATTGCACGAGGCGATCGACTCCATCGCTGAGCACGCGCACCAACGCCTGCTGCGCGACGGCCGCGGCGCCCGCACCATCACGGTGAAGCTAAAGAAATCCGACATGAGCACGCTAACCCGCTCGGCGACGATGCCCTACCCGACGACCGACGCCGGCGCGCTGTTTACGGTGGCCCGCCGGCTGCTGCCGGATCCACTGCAAATCGGGCCAATTCGTCTTCTGGGTGTTGGGTTTTCGGGTTTGAGCGACATTCGCCAGGAGTCGTTGTTTGCCGACTCGGACTTGACGCAGGAAACGGCGGCAGCGCATTACGTCGAAACACCGGGAGCGGTCGTGCCGGCCGCGCACGACGCCACGATGTGGCGGGTCGGCGATGACGTCGCCCACCCTGAGCTTGGGCACGGCTGGGTGCAGGGAGCGGGCCACGGCGTGGTCACCGTGCGGTTCGAAACGCGTGGTTCAGGCCCGGGCTCGGCGCGGACGTTCCCCGTCGACACCGGCGACATCAGCAACGCCAGCCCGCTTGACAGCTTGGACTGGCCGGACTACATCGGCCAGCTATCGGTCGAGGGGTCCGCCGGCGCCTCAGCCCCAACGGTCGATGACGTCGGCGACCGGTGA
- Drug Resistance
- Mutations
- Function
- Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). {ECO:0000250}.
- Family
-
DNA polymerase type-Y family
- GO
-
- SOS response GO:0009432 biological_process
- magnesium ion binding GO:0000287 molecular_function
- DNA-directed DNA polymerase activity GO:0003887 molecular_function
- error-prone translesion synthesis GO:0042276 biological_process
- translesion synthesis GO:0019985 biological_process
- cytosol GO:0005829 cellular_component
- damaged DNA binding GO:0003684 molecular_function
- DNA-dependent DNA replication GO:0006261 biological_process
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- DNA polymerase IV 1 (Pol IV 1) (EC 2.7.7.7)
- Family
- DNA polymerase type-Y family
- Protein Sequence
-
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
- Mass
- 49,765 Da
- Length
- 468 Aa
Rv1537 doesn't seem to be a targeted by any drug.
Rv1537 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.