lspA
- Type
- protein_coding
- Name
- lspA
- Locus Name
-
Rv1539
- Product
-
Probable lipoprotein signal peptidase LspA
- Functional Category
-
Cell wall and cell processes
- Location
- 1742244..1742852 (+ strand)
- Gene Length
- 608 bp
- Nucleotides
-
TGCCTGACGAACCAACAGGATCGGCTGATCCGCTGACCTCGACCGAGGAAGCCGGGGGGGCGGGGGAACCTAACGCTCCCGCGCCGCCGCGACGGCTGCGCATGCTGCTGTCGGTCGCTGTGGTGGTGCTCACACTCGACATTGTCACCAAGGTGGTAGCTGTCCAACTGTTGCCGCCCGGCCAGCCGGTGTCGATTATCGGCGACACGGTGACCTGGACTCTGGTGCGTAATTCTGGGGCGGCCTTCTCGATGGCGACCGGATACACCTGGGTTTTGACGCTGATTGCGACGGGTGTCGTGGTCGGAATTTTCTGGATGGGGCGGCGGCTGGTATCGCCGTGGTGGGCGCTGGGTCTTGGGATGATCCTGGGCGGTGCCATGGGCAACCTGGTTGATCGCTTCTTTCGGGCACCGGGGCCGCTGCGCGGGCACGTCGTCGATTTCTTGTCGGTCGGCTGGTGGCCGGTGTTCAATGTCGCCGATCCGTCGGTAGTCGGTGGCGCCATCCTGCTGGTCATCCTGTCGATCTTTGGCTTTGACTTCGACACCGTAGGTCGGCGACACGCCGACGGGGACACCGTAGGTCGGCGCAAAGCCGATGGCTGA
- Drug Resistance
- Mutations
- Function
- This protein specifically catalyzes the removal of signal peptides from prolipoproteins. {ECO:0000250}.
- Family
-
Peptidase A8 family
- GO
-
- pathogenesis GO:0009405 biological_process
- plasma membrane GO:0005886 cellular_component
- protein lipidation GO:0006497 biological_process
- aspartic-type endopeptidase activity GO:0004190 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II)
- Family
- Peptidase A8 family
- Protein Sequence
-
MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVLTLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVVGIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNVADPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG
- Mass
- 21,345 Da
- Length
- 202 Aa
Rv1539 doesn't seem to be a targeted by any drug.
-
-
Protein export mtu03060
mtu03060Genetic Information Processing; Folding, sorting and degradation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.