Gene - combatTB X

treX

Type: protein_coding
Name: treX
Locus Name: Rv1564c
Product: Probable maltooligosyltrehalose synthase TreX
Functional Category: Virulence, detoxification, adaptation
Location: 1769436..1771601 (- strand)
Gene Length: 2165 bp
Nucleotides: ATGTCGTCGAACAACGCCGGGGAGTCCGACGGGACCGGGCCCGCTCTACCCACGGTGTGGCCGGGCAACGCCTATCCGCTTGGAGCCACCTACGACGGCGCCGGGACCAACTTTTCGTTGTTCTCCGAGATCGCCGAGAAGGTCGAGCTATGTCTGATCGACGAGGACGGCGTCGAGTCGCGGATCCCGCTTGACGAGGTGGACGGGTACGTCTGGCATGCCTATCTGCCGAACATCACCCCCGGCCAGCGCTACGGGTTTCGTGTGCACGGGCCGTTCGACCCGGCGGCCGGCCATCGGTGTGACCCCAGCAAGCTGCTGCTCGACCCGTATGGGAAGTCGTTCCACGGCGATTTCACCTTCGGGCAGGCGCTGTATTCCTATGACGTCAACGCCGTCGACCCGGACAGCACTCCCCCGATGGTCGACTCGCTGGGCCACACTATGACCAGCGTCGTGATCAATCCGTTCTTCGACTGGGCATACGACCGGTCGCCGCGCACCCCGTACCACGAGACCGTAATCTACGAAGCGCATGTCAAAGGCATGACACAGACCCATCCCAGTATCCCGCCCGAACTCCGGGGCACCTACGCCGGCCTGGCCCACCCGGTGATCATCGACCACCTCAACGAGCTCAACGTCACCGCCGTTGAGTTGATGCCGGTGCACCAGTTCCTACACGACTCCCGGCTGCTGGACCTCGGCTTGCGAAACTACTGGGGTTACAACACCTTCGGATTCTTCGCCCCGCACCATCAATACGCGTCGACCCGGCAAGCCGGCAGCGCGGTAGCCGAGTTCAAAACCATGGTGCGCAGCCTGCACGAAGCCGGCATCGAGGTCATCCTCGACGTCGTCTACAACCACACCGCTGAAGGCAACCACTTGGGTCCGACGATCAACTTTCGCGGAATCGACAACACCGCCTACTACCGACTGATGGACCACGACTTGAGGTTCTACAAGGACTTCACCGGTACCGGCAACAGCCTCAATGCCCGCCACCCACACACCCTGCAGCTGATCATGGATTCGCTGCGCTACTGGGTGATCGAAATGCACGTCGACGGGTTCCGGTTCGACCTGGCGTCCACGCTGGCCCGCGAGCTGCACGACGTCGACCGGCTGTCGGCATTCTTCGATCTGGTGCAACAAGATCCGGTGGTCAGTCAGGTCAAGCTGATCGCCGAGCCATGGGATGTCGGCGAAGGTGGCTACCAGGTTGGCAACTTCCCAGGACTGTGGACGGAATGGAACGGCAAGTACCGCGACACCGTGCGCGACTACTGGCGAGGCGAGCCGGCCACCCTAGGCGAATTCGCCTCCCGGCTGACCGGGTCGTCGGACCTCTACGAAGCAACCGGCCGCCGGCCCAGTGCCAGTATCAATTTCGTCACCGCCCACGACGGGTTCACACTCAACGACCTGGTCTCGTACAACGACAAGCACAACGAGGCCAATGGCGAGAACAACCGCGACGGGGAAAGCTACAACCGATCGTGGAACTGCGGTGTCGAGGGCCCCACCGATGACCCCGACATCTTGGCGCTGCGTGCCCGCCAGATGCGCAACATGTGGGCCACGCTTATGGTCAGCCAGGGCACGCCGATGATCGCCCACGGCGACGAGATTGGGCGCACCCAATACGGCAACAACAACGTCTACTGCCAGGACTCCGAATTATCTTGGATGGATTGGTCATTGGTGGACAAGAATGCCGATCTGCTAGCTTTCGCACGCAAGGCGACGACCTTGCGCAAGAACCACAAGGTGTTTCGCCGACGCCGGTTCTTTGAGGGTGAACCGATCCGCAGTGGCGACGAAGTCCGCGATATCGCCTGGTTGACACCGAGCGGTCGGGAGATGACGCACGAGGATTGGGGCAGAGGCTTCGACAGGTGTGTTGCGGTGTTTCTCAACGGTGAAGCCATTACCGCACCGGACGCCCGTGGTGAGCGAGTAGTCGACGATTCATTCCTGTTGTGCTTCAACGCCCATGACCACGACGTGGAGTTCGTGATGCCGCATGACGGCTATGCGCAGCAGTGGACCGGAGAGCTGGATACCAACGATCCCGTCGGTGACATCGACCTGACGGTAACCGCCACTGACACGTTTTCGGTACCTGCGCGCTCGCTGCTGGTCCTGCGTAAGACGTTGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Glycosyl hydrolase 13 family

GO

glycogen catabolic process GO:0005980 biological_process
hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 molecular_function
glycogen debranching enzyme activity GO:0004133 molecular_function

InterPro

UniProt: P9WQ25
GenBank: Rv1564c
EnsemblBacteria: Rv1564c
Mycobrowser: Rv1564c

Summary

Name: Glycogen operon protein GlgX homolog (EC 3.2.1.-)
Family: Glycosyl hydrolase 13 family
Protein Sequence: MSSNNAGESDGTGPALPTVWPGNAYPLGATYDGAGTNFSLFSEIAEKVELCLIDEDGVESRIPLDEVDGYVWHAYLPNITPGQRYGFRVHGPFDPAAGHRCDPSKLLLDPYGKSFHGDFTFGQALYSYDVNAVDPDSTPPMVDSLGHTMTSVVINPFFDWAYDRSPRTPYHETVIYEAHVKGMTQTHPSIPPELRGTYAGLAHPVIIDHLNELNVTAVELMPVHQFLHDSRLLDLGLRNYWGYNTFGFFAPHHQYASTRQAGSAVAEFKTMVRSLHEAGIEVILDVVYNHTAEGNHLGPTINFRGIDNTAYYRLMDHDLRFYKDFTGTGNSLNARHPHTLQLIMDSLRYWVIEMHVDGFRFDLASTLARELHDVDRLSAFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPGLWTEWNGKYRDTVRDYWRGEPATLGEFASRLTGSSDLYEATGRRPSASINFVTAHDGFTLNDLVSYNDKHNEANGENNRDGESYNRSWNCGVEGPTDDPDILALRARQMRNMWATLMVSQGTPMIAHGDEIGRTQYGNNNVYCQDSELSWMDWSLVDKNADLLAFARKATTLRKNHKVFRRRRFFEGEPIRSGDEVRDIAWLTPSGREMTHEDWGRGFDRCVAVFLNGEAITAPDARGERVVDDSFLLCFNAHDHDVEFVMPHDGYAQQWTGELDTNDPVGDIDLTVTATDTFSVPARSLLVLRKTL
Mass: 81,081 Da
Length: 721 Aa

Rv1564c doesn't seem to be a targeted by any drug.

Starch and sucrose metabolism mtu00500
mtu00500
PATHWAY_MAP mtu00500 Starch and sucrose metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.