bioF1
- Type
- protein_coding
- Name
- bioF1
- Locus Name
-
Rv1569
- Product
-
Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1776702..1777862 (+ strand)
- Gene Length
- 1160 bp
- Nucleotides
-
TGAAAGCCGCCACGCAGGCACGGATCGACGATTCACCGTTGGCCTGGTTGGACGCGGTGCAGCGGCAGCGCCACGAGGCCGGACTGCGGCGCTGCCTGCGGCCGCGTCCCGCGGTCGCCACCGAGCTGGACTTGGCCTCCAACGACTATCTCGGTCTGTCCCGACATCCCGCCGTCATCGACGGCGGCGTCCAGGCGCTGCGGATCTGGGGCGCCGGCGCCACCGGGTCGCGCCTGGTTACCGGCGACACCAAGCTGCACCAGCAATTCGAGGCCGAGCTCGCCGAGTTCGTCGGCGCTGCCGCGGGATTGCTGTTCTCCTCTGGCTACACGGCCAACCTGGGCGCCGTGGTCGGCCTGTCCGGCCCGGGTTCCCTGCTGGTGTCCGACGCCCGTTCGCATGCGTCGTTGGTGGATGCCTGTCGGCTGTCGCGGGCGCGGGTTGTGGTGACGCCGCACCGCGACGTCGACGCCGTGGACGCCGCGCTGCGATCGCGCGACGAGCAGCGCGCCGTCGTCGTCACCGACTCGGTGTTCAGCGCCGACGGCTCGCTGGCGCCGGTTCGGGAGTTGCTTGAGGTCTGCCGGCGTCATGGTGCGCTGCTTCTGGTGGACGAGGCGCACGGCCTGGGTGTGCGTGGCGGCGGACGCGGGCTGCTCTACGAGTTAGGTCTAGCGGGTGCGCCCGACGTGGTGATGACCACCACGCTGTCCAAGGCGCTGGGCAGCCAGGGTGGTGTGGTGCTCGGGCCGACGCCGGTGCGGGCCCATCTGATCGATGCTGCCCGGCCGTTCATCTTCGACACCGGTCTGGCGCCGGCGGCGGTGGGTGCCGCACGGGCCGCGCTGCGCGTCTTGCAGGCCGAGCCGTGGCGACCGCAGGCGGTGCTCAACCACGCTGGTGAACTTGCGCGGATGTGCGGTGTGGCTGCGGTGCCGGACTCGGCGATGGTGTCGGTGATCCTGGGCGAGCCGGAGTCGGCAGTGGCCGCCGCGGCGGCCTGCCTGGACGCCGGGGTCAAGGTGGGCTGCTTCCGGCCGCCGACGGTGCCCGCGGGTACGTCGCGGCTGCGGCTGACCGCGCGCGCATCGCTGAACGCCGGCGAGCTCGAGCTGGCCCGGCGGGTGCTGACGGATGTTCTCGCCGTGGCGCGCCGTTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. To a lesser extent, can also utilize D-alanine instead of L-alanine as substrate. {ECO:0000250, ECO:0000269|PubMed:16769720}.
- Family
-
Class-II pyridoxal-phosphate-dependent aminotransferase family, BioF subfamily
- GO
-
- biotin biosynthetic process GO:0009102 biological_process
- 8-amino-7-oxononanoate synthase activity GO:0008710 molecular_function
- cell wall GO:0005618 cellular_component
- plasma membrane GO:0005886 cellular_component
- pyridoxal phosphate binding GO:0030170 molecular_function
- InterPro
Summary
- Name
- 8-amino-7-oxononanoate synthase 1 (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase)
- Family
- Class-II pyridoxal-phosphate-dependent aminotransferase family, BioF subfamily
- Protein Sequence
-
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
- Mass
- 40,028 Da
- Length
- 386 Aa
Rv1569 doesn't seem to be a targeted by any drug.
-
-
Biotin metabolism mtu00780
mtu00780Metabolism; Metabolism of cofactors and vitamins
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies.
- J Biol Chem. 2006 Sep 1;281(35):25076-88. doi: 10.1074/jbc.M604477200. Epub 2006 Jun 12.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.