hisB
- Type
- protein_coding
- Name
- hisB
- Locus Name
-
Rv1601
- Product
-
Probable imidazole glycerol-phosphate dehydratase HisB
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1802035..1802667 (+ strand)
- Gene Length
- 632 bp
- Nucleotides
-
TGACAACCACCCAGACAGCCAAAGCTAGCCGGCGGGCGCGTATCGAACGGCGTACCCGCGAATCCGATATCGTCATCGAGCTCGACCTTGACGGTACCGGGCAGGTGGCCGTCGACACCGGTGTTCCGTTCTACGACCACATGTTGACCGCGCTGGGCAGTCACGCCAGCTTCGACCTCACCGTGCGCGCCACAGGTGATGTCGAAATCGAAGCCCATCACACCATCGAGGACACGGCAATCGCGCTGGGCACCGCGCTCGGGCAGGCCCTAGGTGACAAGAGGGGCATCCGCCGGTTTGGCGATGCCTTCATCCCGATGGACGAAACACTGGCCCACGCCGCCGTCGACTTATCCGGCCGCCCCTATTGCGTGCATACCGGAGAGCCGGATCACCTGCAGCACACCACTATTGCCGGCAGTTCAGTGCCCTACCACACCGTCATCAACCGGCACGTGTTCGAATCGTTGGCGGCCAACGCCCGCATCGCGCTGCACGTCCGCGTGTTGTACGGGCGCGACCCGCACCATATCACCGAAGCTCAATACAAGGCCGTCGCGCGCGCGTTGCGTCAAGCGGTCGAGCCAGATCCTCGGGTGTCAGGCGTGCCGTCCACCAAAGGTGCTCTGTGA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Imidazoleglycerol-phosphate dehydratase family
- GO
-
- metal ion binding GO:0046872 molecular_function
- cytoplasm GO:0005737 cellular_component
- histidine biosynthetic process GO:0000105 biological_process
- imidazoleglycerol-phosphate dehydratase activity GO:0004424 molecular_function
- InterPro
4GQU
- Name
- Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19)
- Family
- Imidazoleglycerol-phosphate dehydratase family
- Protein Sequence
-
MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL
- Mass
- 22,770 Da
- Length
- 210 Aa
Summary
Rv1601 doesn't seem to be a targeted by any drug.
-
-
Histidine metabolism mtu00340
mtu00340PATHWAY_MAP mtu00340 Histidine metabolism
-
- Structures of native, substrate-bound and inhibited forms of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.
- Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2461-7. doi: 10.1107/S0907444913022579. Epub 2013 Nov 19.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.