hisA
- Type
- protein_coding
- Name
- hisA
- Locus Name
-
Rv1603
- Product
-
Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1803294..1804031 (+ strand)
- Gene Length
- 737 bp
- Nucleotides
-
TGATGCCGCTGATACTTTTGCCCGCCGTCGACGTGGTCGAGGGTCGTGCCGTGCGCCTCGTTCAAGGGAAGGCCGGCAGCCAAACCGAGTACGGCTCAGCGGTGGATGCCGCGTTGGGCTGGCAACGCGATGGCGCCGAGTGGATCCATTTGGTGGACCTGGATGCTGCGTTCGGCCGCGGTTCCAACCACGAACTGCTTGCCGAGGTTGTCGGCAAGCTCGACGTACAGGTTGAGCTATCCGGCGGTATTCGAGACGACGAGTCGCTGGCCGCGGCGCTGGCCACCGGATGCGCTCGGGTCAATGTGGGCACTGCTGCCCTGGAAAACCCGCAGTGGTGTGCCCGGGTGATTGGCGAGCACGGCGACCAGGTCGCCGTCGGCTTGGACGTCCAGATCATCGACGGCGAGCATCGGTTGCGCGGACGCGGCTGGGAAACCGACGGCGGCGACCTGTGGGACGTGCTAGAACGCCTAGACAGTGAAGGATGTTCGCGGTTCGTCGTGACCGATATCACCAAGGACGGCACCCTGGGCGGCCCCAATCTGGACCTGCTGGCCGGTGTTGCCGACCGCACCGACGCCCCGGTGATCGCGTCCGGAGGTGTGTCCAGCCTCGATGACCTGCGCGCCATTGCGACTCTCACGCACCGCGGCGTCGAGGGGGCCATCGTCGGCAAGGCCCTCTACGCCCGTCGGTTCACCTTGCCGCAAGCGTTGGCCGCGGTTCGGGACTAG
- Drug Resistance
- Mutations
- Function
- Involved in both the histidine and tryptophan biosynthetic pathways.
- Family
-
HisA/HisF family
- GO
-
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity GO:0003949 molecular_function
- cytoplasm GO:0005737 cellular_component
- histidine biosynthetic process GO:0000105 biological_process
- tryptophan biosynthetic process GO:0000162 biological_process
- phosphoribosylanthranilate isomerase activity GO:0004640 molecular_function
- InterPro
2Y85
- Name
- Phosphoribosyl isomerase A (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) (EC 5.3.1.16) (N-(5'-phosphoribosyl)anthranilate isomerase) (PRAI) (EC 5.3.1.24) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)
- Family
- HisA/HisF family
- Protein Sequence
-
MPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQALAAVRD
- Mass
- 25,632 Da
- Length
- 244 Aa
Summary
Rv1603 doesn't seem to be a targeted by any drug.
-
-
Phenylalanine, tyrosine and tryptophan biosynthesis mtu00400
mtu00400PATHWAY_MAP mtu00400 Phenylalanine, tyrosine and tryptophan biosynthesis
-
-
-
Histidine metabolism mtu00340
mtu00340PATHWAY_MAP mtu00340 Histidine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis.
- EMBO Rep. 2003 Mar;4(3):296-300. doi: 10.1038/sj.embor.embor771.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.