impA
- Type
- protein_coding
- Name
- impA
- Locus Name
-
Rv1604
- Product
-
Probable inositol-monophosphatase ImpA (imp)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1804039..1804851 (+ strand)
- Gene Length
- 812 bp
- Nucleotides
-
TGCACTTGGATTCGTTGGTTGCCCCGCTGGTTGAACAGGCGTCGGCGATCCTGGATGCCGCAACGGCGCTCTTTCTCGTCGGTCATCGCGCCGATTCAGCGGTCCGCAAGAAGGGTAACGACTTCGCCACCGAAGTCGATCTAGCGATCGAGCGGCAGGTTGTCGCAGCGCTGGTGGCGGCCACCGGCATCGAGGTGCACGGCGAGGAGTTCGGCGGCCCGGCAGTCGACTCGCGGTGGGTGTGGGTACTGGACCCCATCGACGGCACAATCAACTACGCCGCCGGATCGCCGTTGGCTGCGATCCTGTTGGGCCTGCTGCACGACGGAGTTCCGGTGGCCGGCTTGACCTGGATGCCATTCACCGACCCACGCTATACCGCCGTGGCGGGTGGTCCGCTGATCAAGAACGGTGTACCGCAGCCGCCGCTGGCTGACGCCGAACTGGCCAACGTGCTCGTCGGCGTCGGCACATTCAGCGCCGACTCACGGGGCCAGTTCCCGGGGCGATATCGACTGGCGGTGCTGGAAAAGCTCAGCCGAGTGTCATCGCGGCTGCGCATGCACGGATCCACCGGCATCGATCTCGTCTTCGTCGCTGACGGGATACTCGGTGGTGCAATAAGTTTCGGAGGTCACGTTTGGGACCATGCCGCTGGGGTGGCGTTGGTACGAGCCGCCGGTGGCGTGGTCACCGACCTGGCTGGGCAACCGTGGACCCCTGCATCGCGTTCTGCCTTGGCCGGGCCACCGCGCGTGCATGCCCAGATCCTCGAGATTCTTGGCAGCATAGGGGAACCAGAGGACTACTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria. {ECO:0000250}.
- Family
-
Inositol monophosphatase superfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- inositol phosphate dephosphorylation GO:0046855 biological_process
- phosphatidylinositol phosphorylation GO:0046854 biological_process
- signal transduction GO:0007165 biological_process
- inositol monophosphate 4-phosphatase activity GO:0052833 molecular_function
- inositol monophosphate 3-phosphatase activity GO:0052832 molecular_function
- inositol biosynthetic process GO:0006021 biological_process
- inositol monophosphate 1-phosphatase activity GO:0008934 molecular_function
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- Probable inositol 1-monophosphatase ImpA (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25)
- Family
- Inositol monophosphatase superfamily
- Protein Sequence
-
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAILLGLLHDGVPVAGLTWMPFTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWTPASRSALAGPPRVHAQILEILGSIGEPEDY
- Mass
- 27,979 Da
- Length
- 270 Aa
Rv1604 doesn't seem to be a targeted by any drug.
-
-
Streptomycin biosynthesis mtu00521
mtu00521Metabolism; Biosynthesis of other secondary metabolites
-
- Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
- BMC Microbiol. 2010 Feb 18;10:50. doi: 10.1186/1471-2180-10-50.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.