Function

Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene) (PubMed:21835980). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the "tag peptide" encoded by the tmRNA and thus targeted for degradation (By similarity). {ECO:0000250|UniProtKB:P0AG67, ECO:0000269|PubMed:21835980}.; FUNCTION: Binds pyrazinoic acid (POA), the active form of the prodrug pyrazinamide (PZA); POA disrupts tmRNA binding (at 50 ug/ml in vitro) and also trans-translation (at 25 ug/ml in vitro using purified H37Ra ribosomes). {ECO:0000269|PubMed:21835980}.

Family

Bacterial ribosomal protein bS1 family

GO

• cytosolic small ribosomal subunit GO:0022627 cellular_component
• structural constituent of ribosome GO:0003735 molecular_function
• mRNA binding GO:0003729 molecular_function
• cell wall GO:0005618 cellular_component
• cytosol GO:0005829 cellular_component
• plasma membrane GO:0005886 cellular_component
• translation GO:0006412 biological_process

InterPro

• IPR012340
• IPR022967
• IPR003029

UniProt

P9WH43

GenBank

Rv1630

EnsemblBacteria

Rv1630

Mycobrowser

Rv1630

Rv1630 doesn't seem to be a targeted by any drug.

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  Ribosome mtu03010

  mtu03010

  PATHWAY_MAP mtu03010 Ribosome