Function

Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides. {ECO:0000269|PubMed:19649276}.

Family

LPG synthetase family; Class-II aminoacyl-tRNA synthetase family

GO

• phosphatidylglycerol metabolic process GO:0046471 biological_process
• response to antibiotic GO:0046677 biological_process
• pathogenesis GO:0009405 biological_process
• magnesium ion binding GO:0000287 molecular_function
• stabilization of membrane potential GO:0030322 biological_process
• phospholipid biosynthetic process GO:0008654 biological_process
• lysyltransferase activity GO:0050071 molecular_function
• cell wall GO:0005618 cellular_component
• ATP binding GO:0005524 molecular_function
• cytosol GO:0005829 cellular_component
• DNA binding GO:0003677 molecular_function
• plasma membrane GO:0005886 cellular_component
• lysine-tRNA ligase activity GO:0004824 molecular_function
• lysyl-tRNA aminoacylation GO:0006430 biological_process
• integral component of membrane GO:0016021 cellular_component
• tRNA binding GO:0000049 molecular_function

InterPro

• IPR004364
• IPR006195
• IPR024320
• IPR002313
• IPR018149
• IPR012340
• IPR004365
• IPR031553

UniProt

P9WFU7

GenBank

Rv1640c

EnsemblBacteria

Rv1640c

Mycobrowser

Rv1640c

Rv1640c doesn't seem to be a targeted by any drug.

Rv1640c doesn't seem to be involved in any pathway.