Gene - combatTB X

infC

Type: protein_coding
Name: infC
Locus Name: Rv1641
Product: Probable initiation factor if-3 InfC
Functional Category: Information pathways
Location: 1852273..1852878 (+ strand)
Gene Length: 605 bp
Nucleotides: TCAGCACTGAAACCCGCGTCAACGAGCGCATCCGCGTACCTGAAGTCCGATTGATCGGCCCAGGGGGGGAGCAGGTAGGCATTGTGCGTATCGAAGACGCACTTCGCGTCGCCGCGGACGCAGATCTCGACCTTGTCGAAGTTGCTCCCAATGCCAGACCGCCGGTCTGCAAGATCATGGACTACGGCAAGTACAAGTACGAGGCCGCGCAGAAGGCGCGCGAATCCCGCAGAAACCAACAGCAGACCGTCGTCAAAGAACAAAAGCTGCGACCAAAGATTGACGATCACGATTACGAGACCAAAAAGGGTCACGTCGTCCGCTTCTTGGAGGCGGGATCGAAGGTCAAGGTCACCATTATGTTCCGTGGACGTGAGCAGTCGCGGCCGGAGTTGGGCTATCGATTGCTGCAGCGGCTGGGTGCGGACGTCGCCGATTACGGATTCATCGAGACGTCCGCCAAGCAGGACGGACGCAACATGACGATGGTGCTGGCACCGCACCGCGGTGCGAAGACCCGCGCTAGGGCCCGCCACCCGGGTGAACCGGCCGGCGGGCCGCCGCCCAAGCCCACGGCCGGTGACAGCAAAGCCGCACCGAACTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. {ECO:0000255|HAMAP-Rule:MF_00080}.

Family

IF-3 family

GO

translation initiation factor activity GO:0003743 molecular_function
ribosome binding GO:0043022 molecular_function
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
ribosome disassembly GO:0032790 biological_process
membrane GO:0016020 cellular_component

InterPro

UniProt: P9WKJ9
GenBank: Rv1641
EnsemblBacteria: Rv1641
Mycobrowser: Rv1641

Summary

Name: Translation initiation factor IF-3
Family: IF-3 family
Protein Sequence: MSTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLDLVEVAPNARPPVCKIMDYGKYKYEAAQKARESRRNQQQTVVKEQKLRPKIDDHDYETKKGHVVRFLEAGSKVKVTIMFRGREQSRPELGYRLLQRLGADVADYGFIETSAKQDGRNMTMVLAPHRGAKTRARARHPGEPAGGPPPKPTAGDSKAAPN
Mass: 22,333 Da
Length: 201 Aa

Rv1641 doesn't seem to be a targeted by any drug.

Rv1641 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.