Gene - combatTB X

PE_PGRS30

Type: protein_coding
Name: PE_PGRS30
Locus Name: Rv1651c
Product: PE-PGRS family protein PE_PGRS30
Functional Category: Pe/ppe
Location: 1862347..1865382 (- strand)
Gene Length: 3035 bp
Nucleotides: ATGTCGTTCTTACTCGTGGAGCCGGACTTGGTCACAGCAGCGGCCGCCAATTTAGCTGGTATTCGCTCGGCACTGAGCGAAGCCGCTGCCGCCGCATCGACCCCCACGACCGCGCTGGCATCGGCCGGCGCCGATGAGGTGTCGGCGGCTGTCTCGCGACTATTCGGCGCCTACGGTCAGCAATTTCAAGCGCTCAACGCCCGGGCGGCGACGTTTCACGCCGAGTTCGTGAGCTTGTTGAACGGCGGCGCGGCGGCCTATACCGGCGCCGAGGCCGCCAGCGTGTCGTCGATGCAGGCCCTGCTCGACGCGGTGAATGCGCCCACGCAGACGCTGCTGGGGCGCCCACTGATCGGCAACGGCGCCGATGGAGTGGCGGGGACCGGGTCAAATGCCGGCGGCAACGGCGGGCCCGGTGGAATTTTGTACGGCAACGGCGGCAACGGCGGGGCCGGCGGTAACGGCGGGGCCGCCGGATTGATCGGCAACGGCGGCGCCGGCGGCGCCGGCGGTGCTGGAGGTGCAGGCGGCGCTGGCGGGGCCGGCGGCACCGGCGGACTGTTGTATGGCAACGGCGGTGCCGGCGGCAACGGGGGCAGTGCCGCTGCGGCCGGTGGGGCCGGCGGCAACGCCCTGCTGTTCGGCAACGGCGGGAACGGCGGAAGTGGGGCTTCCGGCGGAGCCGCCGGCCACGCCGGGACGATATTTGGTAACGGCGGCAATGCTGGGGCCGGATCGGGGCTAGCCGGCGCGGACGGCGGGTTGTTCGGCAATGGCGGGGACGGTGGTTCCAGCACCTCGAAGGCTGGCGGTGCAGGTGGAAATGCACTGTTCGGCAACGGCGGGGACGGCGGATCGAGCACCGTCGCCGCCGGGGGTGCGGGCGGGAATACCCTGGTCGGCAATGGCGGTGCCGGCGGCGCTGGCGGCACCAGCGGTCTCACCGGTAGCGGCGTGGCCGGCGGGGCCGGCGGCAGCGTCGGCCTGTGGGGCTCCGGCGGTGCCGGCGGCGACGGCGGCGCCGCCACGTCATTGTTGGGCGTCGGCATGAACGCCGGCGCTGGCGGGGCCGGCGGCAACGCCGGCCTGCTGTACGGCAACGGCGGTGCCGGTGGGGCCGGCGGCAATGGTGGGGATACGACGGTGCCATTGTTCGACTCCGGCGTCGGCGGTGCCGGGGGTGCTGGCGGCAACGCCAGCTTGTTCGGTAACGGTGGGACCGGTGGCGTCGGCGGCAAGGGGGGGACGAGCAGCGATCTGGCCAGCGCTACCAGCGGAGCCGGCGGGGCCGGCGGGGCCGGCGGCGTCGGCGGGCTGCTCTACGGCAACGGCGGGAACGGGGGGGCCGGTGGCATCGGCGGGGCTGCTATCAACATACTCGCCAACGCCGGTGCCGGCGGCGCCGGTGGTGCCGCGGGCAGTAGCTTCATCGGCAATGGCGGCAACGGTGGGGCCGGTGGCGCCGGTGGGGCTGCAGCGCTATTTAGCTCCGGTGTCGGCGGTGCCGGCGGCAGCGGCGGCACCGCGTTGCTTCTCGGCAGCGGTGGGGCCGGTGGGAACGGCGGCACTGGTGGGGCTAACTCTGGCTCCCTCTTCGCAAGTCCCGGCGGTACCGGCGGTGCCGGCGGTCACGGCGGTGCCGGCGGGCTGATATGGGGCAACGGTGGGGCCGGTGGGAACGGCGGCAACGGTGGCACCACCGCCGATGGCGCCCTTGAGGGTGGCACCGGCGGTATCGGCGGCACCGGAGGCAGCGCCATCGCGTTCGGTAATGGCGGGCAGGGCGGCGCCGGTGGTACCGGTGGGGATCACAGTGGCGGCAACGGTATCGGCGGTAAGGGCGGTGCCAGCGGAAACGGCGGCAACGCCGGCCAAGTGTTCGGCGACGGCGGGACCGGCGGAACCGGCGGCGCGGGCGGCGCCGGTTCCGGTACCAAGGCCGGCGGCACCGGTAGCGACGGCGGTCACGGCGGCAACGCCACCTTGATCGGCAACGGTGGTGACGGTGGCGCCGGTGGCGCCGGCGGCGCCGGCAGCCCGGCCGGTGCCCCGGGTAATGGCGGCACCGGTGGCACCGGCGGGGTGTTGTTCGGCCAAAGTGGCAGCTCCGGTCCACCGGGCGCGGCAGCGCTGGCCTTCCCTAGCCTGAGCAGCAGTGTTCCCATCCTCGGGCCATACGAAGACCTCATCGCCAACACGGTCGCCAACCTGGCGAGCATCGGCAATACCTGGCTTGCCGACCCGGCGCCGTTCCTGCAGCAGTACCTCGCCAACCAGTTCGGCTACGGCCAGCTGACCCTAACCGCGCTGACAGATGCCACCAGGGACTTCGCTATTGGGCTGGCTGGCATACCGCCGAGCCTGCAATCGGCCTTGCAAGCCCTCGCGGCAGGCGACGTCAGCGGCGCGGTGACCGACGTGTTAGGGGCGGTGGTGAAGGTCTTCGTCAGCGGTGTTGACGCGAGTGACTTGTCGAACATCCTGCTGCTCGGGCCGGTGGGAGACCTGTTCCCCATCCTGAGCATCCCCGGCGCCATGTCACAAAACTTCACCAATGTGGTGATGACGGTCACGGACACAACCATCGCCTTTTCGATCGATACCACGAACTTGACCGGGGTGATGACGTTTGGATTGCCGCTGGCGATGACCCTTAATGCGGTGGGTTCGCCGATCACGACGGCAATCGCATTCGCCGAGAGCACGACAGCGTTCGTCAGCGCCGTGCAGGCCGGAAACCTGCAGGCGGCAGCGGCGGCCCTGGTCGGTGCTCCCGCCAACGTCGCCAACGGCTTCCTCAATGGCGAGGCCAGGCTGCCGCTGGCCCTGCCAACATCGGCGACAGGGGGGATTCCGGTGACGGTCGAGGTTCCCGTCGGCGGCATTCTTGCGCCTCTGCAGCCGTTTCAGGCCACGGCGGTAATACCGGTCATCGGGCCGGTTACCGTTACGCTCGAAGGTACGCCCGCCGGCGGCATCGTTCCCGCGTTGGTGAACTACGCTCCCACACAGCTAGCGCAGGCAATTGCCCCTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response (PubMed:27129781). Required for full virulence. Involved in inhibition of phago-lysosome fusion (PubMed:22050772). {ECO:0000269|PubMed:22050772, ECO:0000269|PubMed:27129781}.

Family

Mycobacterial PE family, PGRS subfamily

GO

cell surface GO:0009986 cellular_component
pathogenesis GO:0009405 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component

InterPro

IPR000084

UniProt: Q79FL8
GenBank: Rv1651c
EnsemblBacteria: Rv1651c
Mycobrowser: Rv1651c

Summary

Name: PE-PGRS family protein PE_PGRS30
Family: Mycobacterial PE family, PGRS subfamily
Protein Sequence: MSFLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALASAGADEVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAEAASVSSMQALLDAVNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGGPGGILYGNGGNGGAGGNGGAAGLIGNGGAGGAGGAGGAGGAGGAGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGGNGGSGASGGAAGHAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNALFGNGGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLWGSGGAGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDTTVPLFDSGVGGAGGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGAGGAGGVGGLLYGNGGNGGAGGIGGAAINILANAGAGGAGGAAGSSFIGNGGNGGAGGAGGAAALFSSGVGGAGGSGGTALLLGSGGAGGNGGTGGANSGSLFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTADGALEGGTGGIGGTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFGDGGTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSPAGAPGNGGTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLIANTVANLASIGNTWLADPAPFLQQYLANQFGYGQLTLTALTDATRDFAIGLAGIPPSLQSALQALAAGDVSGAVTDVLGAVVKVFVSGVDASDLSNILLLGPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAFSIDTTNLTGVMTFGLPLAMTLNAVGSPITTAIAFAESTTAFVSAVQAGNLQAAAAALVGAPANVANGFLNGEARLPLALPTSATGGIPVTVEVPVGGILAPLQPFQATAVIPVIGPVTVTLEGTPAGGIVPALVNYAPTQLAQAIAP
Mass: 88,455 Da
Length: 1011 Aa

Rv1651c doesn't seem to be a targeted by any drug.

Rv1651c doesn't seem to be involved in any pathway.

PE_PGRS30 of Mycobacterium tuberculosis mediates suppression of proinflammatory immune response in macrophages through its PGRS and PE domains.: Microbes Infect. 2016 Sep;18(9):536-42. doi: 10.1016/j.micinf.2016.04.004. Epub 2016 Apr 27.
Impact of protein domains on PE_PGRS30 polar localization in Mycobacteria.: PLoS One. 2014 Nov 12;9(11):e112482. doi: 10.1371/journal.pone.0112482. eCollection 2014.
The PGRS domain is responsible for translocation of PE_PGRS30 to cell poles while the PE and the C-terminal domains localize it to the cell wall.: FEBS Lett. 2014 Mar 18;588(6):990-4. doi: 10.1016/j.febslet.2014.01.059. Epub 2014 Feb 11.
PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis.: Cell Microbiol. 2012 Mar;14(3):356-67. doi: 10.1111/j.1462-5822.2011.01721.x. Epub 2011 Dec 13.
The Rv1651c-encoded PE-PGRS30 protein expressed in Mycobacterium smegmatis exhibits polar localization and modulates its growth profile.: FEMS Microbiol Lett. 2011 Sep;322(2):194-9. doi: 10.1111/j.1574-6968.2011.02354.x. Epub 2011 Jul 25.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.