argJ
- Type
- protein_coding
- Name
- argJ
- Locus Name
-
Rv1653
- Product
-
Probable glutamate N-acetyltransferase ArgJ
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1866631..1867845 (+ strand)
- Gene Length
- 1214 bp
- Nucleotides
-
TGACCGACCTGGCCGGCACCACCCGGCTGCTGCGCGCTCAGGGCGTCACCGCCCCGGCCGGCTTTCGGGCCGCCGGCGTCGCCGCCGGGATCAAGGCCTCCGGTGCGCTGGATCTGGCGCTGGTGTTCAACGAGGGACCCGACTACGCCGCCGCCGGGGTGTTCACCCGCAACCAGGTCAAGGCGGCGCCGGTGCTGTGGACCCAGCAAGTGCTGACCACCGGGCGGCTGCGCGCGGTGATCCTCAACTCCGGCGGCGCCAATGCCTGCACCGGGCCGGCCGGCTTCGCCGACACCCACGCCACCGCGGAGGCGGTGGCCGCGGCGTTGTCGGACTGGGGAACCGAGACCGGGGCCATCGAGGTCGCCGTCTGCTCCACCGGGCTGATCGGCGACCGGCTGCCGATGGACAAGCTGCTCGCCGGCGTCGCCCACGTGGTGCACGAGATGCATGGCGGGCTGGTCGGCGGCGATGAAGCCGCCCACGCCATCATGACCACCGACAACGTGCCCAAACAGGTTGCGCTGCACCATCACGACAACTGGACGGTCGGCGGCATGGCCAAAGGCGCGGGCATGCTGGCGCCGTCGTTGGCCACCATGCTGTGCGTGCTCACCACCGACGCGGCCGCCGAGCCGGCCGCACTCGAGCGGGCGCTGCGCCGCGCCGCCGCGGCCACGTTCGACCGGCTCGACATCGACGGCAGCTGCTCCACCAACGACACCGTGCTGCTGCTGTCGTCCGGGGCCAGTGAAATCCCCCCTGCCCAGGCCGATCTCGACGAGGCCGTGCTACGGGTCTGCGACGATTTGTGCGCCCAGCTGCAGGCCGACGCCGAAGGCGTCACCAAACGCGTCACCGTGACCGTGACCGGGGCCGCCACCGAAGACGACGCGCTGGTCGCCGCCCGCCAGATCGCCCGCGACAGCCTGGTCAAGACCGCGCTGTTCGGGTCCGACCCGAACTGGGGACGGGTGCTCGCCGCCGTCGGGATGGCACCGATCACCCTCGACCCGGATCGAATCAGCGTGTCGTTCAACGGTGCCGCGGTGTGTGTGCACGGTGTCGGCGCTCCCGGTGCGCGCGAGGTGGACCTGTCGGACGCGGACATCGATATCACCGTCGACCTCGGCGTCGGCGACGGGCAGGCGAGGATCCGAACCACTGATCTGTCGCATGCCTACGTCGAAGAGAACTCGGCCTACAGCTCATGA
- Drug Resistance
- Mutations
- Function
- Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. {ECO:0000250}.
- Family
-
ArgJ family
- GO
-
- methione N-acyltransferase activity GO:0103045 molecular_function
- cytoplasm GO:0005737 cellular_component
- ornithine biosynthetic process GO:0006592 biological_process
- arginine biosynthetic process GO:0006526 biological_process
- glutamate N-acetyltransferase activity GO:0004358 molecular_function
- acetyl-CoA:L-glutamate N-acetyltransferase activity GO:0004042 molecular_function
- InterPro
3IT4
- Name
- Arginine biosynthesis bifunctional protein ArgJ [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGSase)]
- Family
- ArgJ family
- Protein Sequence
-
MTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFNEGPDYAAAGVFTRNQVKAAPVLWTQQVLTTGRLRAVILNSGGANACTGPAGFADTHATAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKLLAGVAHVVHEMHGGLVGGDEAAHAIMTTDNVPKQVALHHHDNWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALERALRRAAAATFDRLDIDGSCSTNDTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQADAEGVTKRVTVTVTGAATEDDALVAARQIARDSLVKTALFGSDPNWGRVLAAVGMAPITLDPDRISVSFNGAAVCVHGVGAPGAREVDLSDADIDITVDLGVGDGQARIRTTDLSHAYVEENSAYSS
- Mass
- 41,147 Da
- Length
- 404 Aa
Summary
Rv1653 doesn't seem to be a targeted by any drug.
-
-
Arginine biosynthesis mtu00220
mtu00220PATHWAY_MAP mtu00220 Arginine biosynthesis
-
- The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
- J Mol Biol. 2010 Apr 9;397(4):979-90. doi: 10.1016/j.jmb.2010.02.018. Epub 2010 Feb 22.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.