pks10
- Type
- protein_coding
- Name
- pks10
- Locus Name
-
Rv1660
- Product
-
Chalcone synthase Pks10
- Functional Category
-
Lipid metabolism
- Location
- 1874160..1875221 (+ strand)
- Gene Length
- 1061 bp
- Nucleotides
-
TGAGCGTCATCGCAGGTGTGTTCGGCGCGTTGCCGCCGTATCGCTATTCACAACGCGAGCTCACCGACTCGTTTGTCAGCATCCCGGATTTCGAGGGCTACGAAGACATCGTTCGCCAGCTGCACGCCAGCGCCAAAGTCAACAGCCGCCACCTGGTCTTGCCGCTGGAGAAATACCCGAAGCTGACCGACTTCGGCGAGGCGAACAAGATTTTCATCGAAAAAGCCGTGGACTTGGGCGTGCAAGCCCTGGCGGGGGCACTCGACGAGTCCGGTCTGCGACCCGAGGATCTCGACGTGTTGATCACCGCCACGGTCACCGGACTGGCGGTGCCGTCGCTGGATGCCCGGATCGCCGGGCGGCTGGGGCTGCGCGCCGATGTCCGGAGGGTGCCGCTGTTCGGGCTGGGCTGCGTGGCCGGGGCGGCCGGGGTCGCCCGGCTGCACGACTACCTGCGCGGGGCCCCGGACGGCGTTGCCGCGTTGGTCTCGGTCGAGCTGTGTTCACTCACGTATCCGGGATACAAGCCGACGCTGCCGGGCCTTGTCGGCAGTGCGTTGTTTGCTGACGGCGCCGCGGCGGTGGTGGCCGCAGGTGTGAAGCGCGCCCAGGACATCGGCGCCGACGGGCCGGACATCCTGGATTCGCGCAGCCATCTGTACCCCGACTCGCTGCGCACCATGGGATACGACGTCGGCTCGGCCGGGTTCGAGCTCGTCCTATCACGGGACTTGGCGGCCGTGGTCGAGCAGTATCTGGGCAATGACGTCACCACCTTCCTGGCTTCGCACGGCCTGAGCACCACCGACGTCGGCGCCTGGGTCACCCATCCCGGGGGACCCAAGATCATCAACGCCATCACCGAGACCCTCGACCTGTCGCCGCAGGCTCTCGAGCTGACGTGGCGCTCGTTGGGCGAAATCGGGAATCTGTCGTCAGCGTCGGTGCTGCATGTGCTGCGTGACACCATCGCCAAACCGCCCCCCAGCGGAAGTCCCGGGTTGATGATCGCCATGGGCCCAGGCTTCTGTTCCGAACTCGTGTTGCTGCGCTGGCACTGA
- Drug Resistance
- Mutations
- Function
- Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM). {ECO:0000269|PubMed:12730158}.
- Family
-
Thiolase-like superfamily, Chalcone/stilbene synthases family
- GO
-
- DIM/DIP cell wall layer assembly GO:0071770 biological_process
- polyketide synthase complex GO:0034081 cellular_component
- lipid biosynthetic process GO:0008610 biological_process
- plasma membrane GO:0005886 cellular_component
- transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 molecular_function
- fatty acid biosynthetic process GO:0006633 biological_process
- InterPro
Summary
- Name
- Polyketide synthase-like Pks10 (EC 2.3.1.-) (Chalcone synthase-like protein) (CHS-like) (Polyketide synthase type III Pks10)
- Family
- Thiolase-like superfamily, Chalcone/stilbene synthases family
- Protein Sequence
-
MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPGLMIAMGPGFCSELVLLRWH
- Mass
- 37,146 Da
- Length
- 353 Aa
Rv1660 doesn't seem to be a targeted by any drug.
Rv1660 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis.
- J Bacteriol. 2003 May;185(10):2999-3008. doi: 10.1128/jb.185.10.2999-3008.2003.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.