Gene - combatTB X

pks11

Type: protein_coding
Name: pks11
Locus Name: Rv1665
Product: Chalcone synthase Pks11
Functional Category: Lipid metabolism
Location: 1891226..1892287 (+ strand)
Gene Length: 1061 bp
Nucleotides: TGAGCGTCATCGCGGGTGTGTTCGGTGCGTTGCCGCCGCATCGCTATAGCCAAAGTGAGATCACTGATTCGTTTGTCGAGTTTCCCGGCCTTAAGGAACACGAGGAGATCATTCGGCGTTTGCATGCCGCCGCCAAGGTCAACGGTCGACACCTGGTGCTGCCGCTGCAGCAATACCCGTCGCTGACCGACTTCGGCGACGCCAACGAGATCTTTATCGAGAAGGCTGTCGACCTTGGCGTCGAGGCCTTGCTGGGCGCGCTCGATGATGCCAACCTGCGCCCCAGCGACATCGACATGATCGCCACCGCAACCGTCACCGGCGTCGCGGTGCCGTCTTTGGATGCCCGGATCGCCGGGCGGCTTGGTCTGCGCCCCGACGTGCGGCGGATGCCGTTGTTCGGTCTGGGCTGCGTGGCAGGGGCGGCGGGCGTGGCCCGCCTGCGCGACTACCTGCGTGGCGCGCCCGACGACGTCGCGGTTCTGGTCTCGGTTGAGCTTTGCTCGCTGACGTATCCCGCGGTCAAACCAACCGTGTCGAGTCTGGTCGGGACCGCACTGTTCGGCGACGGAGCAGCCGCGGTGGTCGCCGTCGGCGACCGGCGCGCCGAGCAGGTTCGCGCTGGCGGACCGGACATCTTGGACTCGCGCAGCAGCCTGTACCCCGACTCGCTGCACATCATGGGTTGGGATGTCGGTTCCCATGGCCTGCGGCTGCGGCTTTCCCCGGACCTGACGAACCTGATCGAACGGTACCTAGCCAATGACGTCACCACGTTTCTTGATGCCCATCGGCTGACCAAAGACGACATCGGCGCCTGGGTGAGCCATCCCGGTGGTCCCAAGGTCATCGACGCCGTCGCCACGAGCCTCGCGCTGCCTCCCGAGGCGCTCGAGCTGACCTGGCGCTCGCTGGGCGAGATCGGCAACCTTTCGTCGGCCTCGATACTGCATATTTTGCGCGACACCATCGAAAAGCGGCCACCCAGCGGAAGCGCCGGGCTGATGCTGGCGATGGGTCCTGGTTTCTGCACGGAACTCGTCTTACTGCGCTGGCGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. {ECO:0000269|PubMed:12941968}.

Family

Thiolase-like superfamily, Chalcone/stilbene synthases family

GO

DIM/DIP cell wall layer assembly GO:0071770 biological_process
chalcone biosynthetic process GO:0009715 biological_process
polyketide synthase complex GO:0034081 cellular_component
lipid biosynthetic process GO:0008610 biological_process
transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 molecular_function
fatty acid biosynthetic process GO:0006633 biological_process

InterPro

UniProt: P9WPF3
GenBank: Rv1665
EnsemblBacteria: Rv1665
Mycobrowser: Rv1665

PDB IDs:

Summary

Name: Alpha-pyrone synthesis polyketide synthase-like Pks11 (EC 2.3.1.-) (Alpha-pyrone synthesis polyketide synthase type III Pks11) (Chalcone synthase-like protein) (CHS-like)
Family: Thiolase-like superfamily, Chalcone/stilbene synthases family
Protein Sequence: MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMGPGFCTELVLLRWR
Mass: 37,639 Da
Length: 353 Aa

Rv1665 doesn't seem to be a targeted by any drug.

Rv1665 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
A new family of type III polyketide synthases in Mycobacterium tuberculosis.: J Biol Chem. 2003 Nov 7;278(45):44780-90. doi: 10.1074/jbc.M306714200. Epub 2003 Aug 26.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.