mctB
- Type
- protein_coding
- Name
- mctB
- Locus Name
-
Rv1698
- Product
-
Outer membrane protein MctB
- Functional Category
-
Cell wall and cell processes
- Location
- 1922745..1923689 (+ strand)
- Gene Length
- 944 bp
- Nucleotides
-
TGATCTCGTTGCGTCAACATGCGGTCTCACTGGCTGCGGTCTTCCTGGCGCTGGCCATGGGCGTAGTGTTGGGTTCCGGCTTTTTCTCCGATACTTTGCTGTCCAGCTTGCGTAGCGAGAAGCGGGACCTCTACACGCAGATCGACCGACTCACCGATCAGCGGGATGCACTTCGCGAAAAGCTCAGCGCGGCAGACAATTTCGATATCCAAGTAGGCAGCCGAATAGTGCACGACGCGCTAGTCGGCAAGTCGGTGGTCATCTTCCGCACCCCGGATGCCCACGACGACGATATCGCTGCGGTGTCGAAGATCGTGGGACAGGCCGGCGGTGCGGTCACCGCAACGGTCTCATTGACCCAGGAGTTCGTCGAAGCCAACTCCGCCGAGAAACTGCGCTCAGTGGTGAACTCGTCCATTCTGCCGGCCGGTAGCCAGTTGAGCACCAAACTCGTTGACCAAGGTTCCCAAGCCGGCGACCTGCTCGGCATCGCCTTGCTGAGCAACGCCGACCCGGCGGCGCCGACTGTCGAGCAGGCGCAGCGGGACACTGTGCTGGCGGCACTGCGCGAAACCGGCTTCATCACCTATCAGCCCCGCGACCGCATTGGGACGGCAAACGCCACGGTGGTGGTCACCGGCGGAGCGCTCTCTACAGACGCCGGCAACCAGGGGGTCAGCGTGGCTCGGTTCGCCGCGGCGCTGGCGCCGCGCGGGTCTGGCACGCTGCTTGCCGGCCGGGACGGTTCGGCGAACCGACCCGCCGCCGTCGCCGTGACCCGCGCCGATGCCGACATGGCGGCCGAAATCAGCACCGTTGACGACATCGACGCCGAGCCCGGACGAATCACCGTGATCCTTGCCCTGCATGACCTGATCAACGGAGGCCACGTGGGGCACTACGGCACCGGTCACGGGGCGATGTCAGTCACGGTTTCCCAGTAG
- Drug Resistance
- Mutations
- Function
- Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence. {ECO:0000269|PubMed:18434314, ECO:0000269|PubMed:21205886}.
- Family
-
MctB (TC 1.B.50) family
- GO
-
- pore complex GO:0046930 cellular_component
- cell outer membrane GO:0009279 cellular_component
- copper ion homeostasis GO:0055070 biological_process
- porin activity GO:0015288 molecular_function
- ion transport GO:0006811 biological_process
- InterPro
Summary
- Name
- Copper transporter MctB (Mycobacterial copper transport protein B)
- Family
- MctB (TC 1.B.50) family
- Protein Sequence
-
MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ
- Mass
- 32,391 Da
- Length
- 314 Aa
Rv1698 doesn't seem to be a targeted by any drug.
Rv1698 doesn't seem to be involved in any pathway.
- Cloning, expression, purification, crystallization and preliminary crystallographic analysis of Rv1698, an outer membrane channel protein from Mycobacterium tuberculosis.
- Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1525-7. doi: 10.1107/S1744309110037644. Epub 2010 Oct 29.
- Copper resistance is essential for virulence of Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1621-6. doi: 10.1073/pnas.1009261108. Epub 2011 Jan 4.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Identification of outer membrane proteins of Mycobacterium tuberculosis.
- Tuberculosis (Edinb). 2008 Nov;88(6):526-44. doi: 10.1016/j.tube.2008.02.004. Epub 2008 Apr 25.
- Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins.
- J Biol Chem. 2008 Jun 27;283(26):17827-37. doi: 10.1074/jbc.M800866200. Epub 2008 Apr 22.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.