Gene - combatTB X

engA

Type: protein_coding
Name: engA
Locus Name: Rv1713
Product: Probable GTP-binding protein EngA
Functional Category: Intermediary metabolism and respiration
Location: 1940288..1941679 (+ strand)
Gene Length: 1391 bp
Nucleotides: TGACCCAGGACGGCACGTGGGTGGACGAAAGCGATTGGCAACTAGACGATTCGGAGATCGCGGAGTCCGGAGCGGCGCCTGTGGTGGCGGTAGTCGGCCGGCCCAATGTCGGCAAGTCCACCCTGGTCAACCGGATCCTGGGCCGCCGCGAGGCGGTGGTGCAGGATATTCCCGGCGTGACGCGTGACCGGGTCTGCTACGACGCGCTGTGGACCGGACGCCGGTTCGTCGTACAGGACACCGGCGGATGGGAGCCCAATGCCAAGGGCCTGCAGCGGTTGGTGGCCGAGCAGGCCTCGGTGGCCATGCGCACCGCGGATGCGGTGATCCTGGTGGTCGACGCCGGTGTCGGTGCCACCGCCGCCGACGAGGCCGCGGCCCGTATCCTGTTGCGATCCGGCAAGCCGGTGTTCTTGGCCGCCAACAAGGTCGACAGCGAAAAAGGCGAATCCGACGCCGCGGCGTTGTGGTCGCTGGGCCTGGGTGAGCCGCATGCGATCAGCGCGATGCACGGTCGGGGGGTGGCCGACCTGCTCGACGGGGTGCTCGCCGCGCTGCCCGAGGTGGGGGAGTCCGCGTCGGCGAGCGGCGGTCCTCGCCGGGTGGCGCTGGTCGGTAAGCCGAACGTCGGCAAGAGCTCCCTGCTGAACAAACTCGCGGGTGATCAGCGATCGGTGGTCCATGAGGCGGCGGGCACCACCGTCGACCCGGTGGATTCGCTGATCGAGTTGGGCGGTGACGTCTGGCGGTTCGTCGACACCGCGGGATTGCGGCGCAAGGTCGGCCAGGCCAGTGGGCATGAGTTCTACGCCTCGGTGCGCACGCACGCCGCCATCGACTCCGCCGAAGTGGCCATCGTCCTGATCGACGCGTCGCAGCCGCTCACCGAACAGGACTTGCGAGTGATATCGATGGTCATCGAGGCCGGACGGGCGCTAGTCCTGGCCTACAACAAGTGGGACCTGGTCGACGAGGACCGGCGCGAGCTGCTTCAGCGCGAGATCGACCGAGAGCTGGTGCAGGTGCGCTGGGCGCAACGGGTCAACATCTCCGCCAAGACGGGCCGGGCGGTGCACAAGCTGGTGCCGGCCATGGAGGATGCGCTGGCGTCATGGGACACCAGGATCGCGACCGGCCCGCTGAACACCTGGCTCACAGAGGTGACGGCGGCCACACCGCCGCCGGTGCGCGGCGGCAAGCAGCCACGCATCTTGTTCGCGACCCAGGCCACCGCGCGGCCACCGACGTTCGTGTTGTTCACCACGGGTTTTTTGGAGGCCGGCTATCGGCGGTTCTTGGAGCGGCGGCTGCGTGAGACGTTCGGGTTTGACGGCAGCCCGATCCGGGTCAACGTGCGGGTGCGAGAGAAGCGGGCCGGCAAGCGCCGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.

Family

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, EngA (Der) GTPase family

GO

ribosome binding GO:0043022 molecular_function
cell wall GO:0005618 cellular_component
GTP binding GO:0005525 molecular_function
plasma membrane GO:0005886 cellular_component
ribosomal large subunit assembly GO:0000027 biological_process

InterPro

UniProt: P9WNL3
GenBank: Rv1713
EnsemblBacteria: Rv1713
Mycobrowser: Rv1713

Summary

Name: GTPase Der (GTP-binding protein EngA)
Family: TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, EngA (Der) GTPase family
Protein Sequence: MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
Mass: 49,958 Da
Length: 463 Aa

Rv1713 doesn't seem to be a targeted by any drug.

Rv1713 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.