gabD2

Type
protein_coding
Name
gabD2
Locus Name

Rv1731

Product

Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2

Functional Category

Intermediary metabolism and respiration

Location
1957677..1959233 (+ strand)
Gene Length
1556 bp
Nucleotides
TGCCTGCACCCTCGGCCGAGGTTTTCGATCGCTTGCGTAACCTGGCCGCGATCAAGGACGTCGCCGCACGTCCGACCAGGACGATCGACGAGGTCTTCACCGGCAAGCCGTTGACTACGATTCCGGTCGGCACGGCCGCGGACGTCGAAGCGGCATTCGCCGAAGCTCGCGCGGCGCAGACCGACTGGGCGAAGCGTCCCGTCATCGAGCGAGCTGCAGTCATCCGCCGCTATCGCGACCTGGTCATCGAGAACCGCGAGTTCCTCATGGACCTCCTGCAAGCCGAGGCGGGCAAGGCCCGATGGGCGGCGCAAGAGGAAATTGTCGATCTGATCGCGAACGCGAATTATTACGCACGAGTCTGTGTGGACCTGCTGAAGCCCCGTAAGGCACAGCCGCTGCTGCCCGGGATAGGCAAGACCACGGTGTGCTATCAACCGAAGGGCGTGGTGGGGGTGATCTCGCCGTGGAACTACCCCATGACGCTTACGGTGTCGGACTCGGTGCCCGCGCTGGTGGCCGGTAACGCGGTGGTGCTCAAGCCGGACAGCCAGACGCCGTATTGTGCGCTCGCGTGTGCCGAGCTGCTGTATCGGGCGGGTCTGCCGCGAGCGCTGTATGCGATCGTGCCCGGTCCGGGCTCGGTGGTGGGCACCGCCATCACCGACAACTGCGACTACCTGATGTTCACCGGTTCATCGGCGACCGGCAGCCGCCTCGCCGAGCACGCCGGCCGCCGGCTTATCGGTTTCTCGGCCGAACTTGGCGGCAAGAACCCCATGATCGTGGCGCGGGGTGCCAACCTCGACAAGGTCGCCAAGGCGGCCACCCGTGCCTGCTTCTCGAACGCCGGCCAGCTGTGCATCTCCATTGAGCGGATCTACGTCGAAAAGGACATCGCCGAGGAGTTCACCCGGAAGTTCGGCGATGCGGTGCGGAACATGAAGCTCGGCACCGCATACGACTTCTCGGTCGACATGGGTAGTTTGATCTCCGAAGCACAGCTGAAAACCGTGTCCGGTCACGTGGATGACGCGACGGCCAAGGGCGCCAAGGTGATTGCGGGCGGCAAGGCTCGACCCGACATCGGGCCGCTGTTCTACGAGCCGACCGTGCTGACCAACGTCGCACCCGAAATGGAATGCGCGGCCAACGAGACGTTCGGGCCGGTGGTCTCGATCTACCCGGTCGCCGACGTGGACGAAGCCGTCGAAAAGGCCAACGACACCGACTACGGGCTCAACGCCAGCGTCTGGGCCGGCTCCACCGCGGAGGGCCAGAGGATCGCCGCCCGGCTGCGGTCGGGGACGGTGAACGTCGACGAGGGGTACGCGTTCGCCTGGGGCAGCCTCAGCGCGCCGATGGGCGGGATGGGCCTCTCGGGGGTCGGCCGCCGGCACGGTCCGGAGGGCTTGCTCAAGTACACCGAATCACAGACGATCGCGACCGCCCGCGTGTTCAATCTCGATCCGCCCTTCGGCATCCCGGCCACAGTCTGGCAGAAGTCACTGTTACCCATCGTGCGCACCGTGATGAAGCTTCCCGGCCGCAGGTGA
Drug Resistance

Check for drug resistance association at TBDREAMDB

Mutations

Check for mutants available at TARGET

Function
Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s). NAD(+) can substitute for NADP(+), but enzymatic activity is three times reduced. {ECO:0000269|PubMed:16027371}.
Family

Aldehyde dehydrogenase family

GO
InterPro
UniProt
P9WNX7
GenBank
Rv1731
EnsemblBacteria
Rv1731
Mycobrowser
Rv1731
Summary
Name
Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2 (SSADH 2) (SSDH 2) (EC 1.2.1.79)
Family
Aldehyde dehydrogenase family
Protein Sequence
MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAAQEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR
Mass
55,324 Da
Length
518 Aa

Rv1731 doesn't seem to be a targeted by any drug.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10670-5. doi: 10.1073/pnas.0501605102. Epub 2005 Jul 18.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.