narX
- Type
- protein_coding
- Name
- narX
- Locus Name
-
Rv1736c
- Product
-
Probable nitrate reductase NarX
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1962228..1964186 (- strand)
- Gene Length
- 1958 bp
- Nucleotides
-
GTGACGGTGACACCACGGACCGGCAGCCGCATCGAGGAGCTGCTTGCACGCAGCGGCCGGTTCTTCATCCCGGGTGAGATCTCGGCGGATCTGCGTACCGTGACCCGCCGCGGCGGCCGCGACGGCGACGTGTTCTATCGAGACCGGTGGAGCCACGACAAGGTGGTCCGCTCCACACACGGGGTGAATTGCACCGGGTCGTGTTCTTGGAAGATCTACGTCAAAGACGACATCATCACCTGGGAGACGCAGGAGACCGACTATCCGTCGGTGGGCCCGGACCGGCCCGAGTATGAGCCCCGCGGCTGCCCGCGCGGCGCGGCGTTTTCCTGGTACACGTATTCGCCGACGCGGGTGCGCCATCCGTACGCCCGCGGCGTGCTTGTCGAGATGTATCGGGAGGCGAAGGCACGTTTGGGTGATCCGGTGGCGGCCTGGGCCGACATCCAGGCCGACCCGCGGCGGCGCCGCCGCTACCAGCGCGCCCGCGGCAAGGGCGGGCTGGTCCGGGTCAGCTGGGCCGAGGCCACCGAGATGATCGCCGCCGCCCACGTGCACACCATCTCCACATACGGCCCGGACCGGGTTGCCGGCTTCTCCCCCATCCCGGCGATGTCCATGGTGAGCCACGCCGCGGGGTCGCGGTTCGTGGAGCTAATCGGCGGGGTGATGACGTCGTTCTACGACTGGTACGCCGACCTGCCGGTGGCCTCCCCGCAGGTGTTCGGCGACCAGACCGACGTGCCGGAGTCCGGAGATTGGTGGGACGTGGTGTGGCAATGCGCCTCGGTGCTGCTGACCTACCCGAACTCACGGCAACTCGGCACCGCAGAGGAATTGCTGGCCCACATCGACGGTCCGGCCGCGGATCTGTTGGGGCGCACGGTCTCTGAGCTGCGCCGTGCCGATCCGCTGACCGCGGCGACCCGCTACGTCGACACCTTCGACCTGCGAGGCCGCGCCACCCTGTACCTGACCTACTGGACCGCCGGCGACACCCGCAACCGCGGCCGGGAGATGCTGGCCTTCGCCCAGACCTACCGCAGCACCGACGTCGCACCACCGCGCGGCGAGACCCCGGACTTCCTGCCGGTGGTGCTCGAATTCGCCGCGACCGTCGACCCCGAGGCGGGGCGACGGTTGCTGAGCGGGTACCGGGTGCCCATCGCCGCGCTGTGCAATGCCCTGACCGAGGCCGCATTGCCATACGCACACACGGTGGCCGCGGTATGCCGGACGGGTGACATGATGGGCGAACTCTTCTGGACCGTCGTGCCGTATGTGACGATGACGATCGTCGCGGTCGGCTCCTGGTGGCGCTACCGCTATGACAAATTCGGCTGGACCACCCGCTCGTCCCAGCTGTACGAGTCGCGGCTGCTGCGGATCGCCAGCCCGATGTTTCATTTCGGCATCCTGGTGGTCATCGTCGGCCACGGTATCGGGCTCGTGATCCCGCAGTCGTGGACTCAGGCCGCCGGTTTGAGCGAGGGCGCATATCACGTGCAGGCCGTCGTGCTGGGGTCGATCGCCGGCATCACCACCTTGGCCGGCGTTACCCTGCTGATCTACCGGCGGCGCACCCGCGGGCCGGTGTTCATGGCTACCACCGTCAACGACAAGGTGATGTACCTCGTGCTGGTGGCGGCGATCGTCGCGGGACTGGGTGCGACGGCGTTGGGCTCCGGCGTTGTCGGCGAGGCGTACAACTACCGCGAGACGGTGTCGGTGTGGTTCCGCTCGGTGTGGGTACTGCAACCGCGCGGGGACCTGATGGCCGAGGCTCCGCTGTATTACCAGATCCATGTGCTGATCGGGTTGGCGTTGTTCGCGTTGTGGCCGTTCACCCGGCTGGTACACGCGTTCAGCGCCCCGATCGGCTATCTGTTCCGCCCGTACATCATCTACCGCAGCCGCGAGGAGCTGGTGCTAACGCGGCCGCGGCGGCGCGGGTGGTG
- Drug Resistance
- Mutations
- Function
- Does not seem to have nitrate reductase activity. {ECO:0000269|PubMed:14645286}.
- Family
-
Nitrate reductase alpha subunit family; NarJ/NarW family; Nitrate reductase gamma subunit family
- GO
-
- metal ion binding GO:0046872 molecular_function
- nitrate reductase complex GO:0009325 cellular_component
- anaerobic respiration GO:0009061 biological_process
- nitrate reductase activity GO:0008940 molecular_function
- plasma membrane GO:0005886 cellular_component
- nitrate assimilation GO:0042128 biological_process
- response to hypoxia GO:0001666 biological_process
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- chaperone-mediated protein complex assembly GO:0051131 biological_process
- unfolded protein binding GO:0051082 molecular_function
- integral component of membrane GO:0016021 cellular_component
- membrane GO:0016020 cellular_component
- InterPro
Summary
- Name
- Nitrate reductase-like protein NarX
- Family
- Nitrate reductase alpha subunit family; NarJ/NarW family; Nitrate reductase gamma subunit family
- Protein Sequence
-
MTVTPRTGSRIEELLARSGRFFIPGEISADLRTVTRRGGRDGDVFYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDDIITWETQETDYPSVGPDRPEYEPRGCPRGAAFSWYTYSPTRVRHPYARGVLVEMYREAKARLGDPVAAWADIQADPRRRRRYQRARGKGGLVRVSWAEATEMIAAAHVHTISTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDVVWQCASVLLTYPNSRQLGTAEELLAHIDGPAADLLGRTVSELRRADPLTAATRYVDTFDLRGRATLYLTYWTAGDTRNRGREMLAFAQTYRSTDVAPPRGETPDFLPVVLEFAATVDPEAGRRLLSGYRVPIAALCNALTEAALPYAHTVAAVCRTGDMMGELFWTVVPYVTMTIVAVGSWWRYRYDKFGWTTRSSQLYESRLLRIASPMFHFGILVVIVGHGIGLVIPQSWTQAAGLSEGAYHVQAVVLGSIAGITTLAGVTLLIYRRRTRGPVFMATTVNDKVMYLVLVAAIVAGLGATALGSGVVGEAYNYRETVSVWFRSVWVLQPRGDLMAEAPLYYQIHVLIGLALFALWPFTRLVHAFSAPIGYLFRPYIIYRSREELVLTRPRRRGW
- Mass
- 72,825 Da
- Length
- 652 Aa
Rv1736c doesn't seem to be a targeted by any drug.
-
-
Two-component system mtu02020
mtu02020Environmental Information Processing; Signal transduction
-
-
-
Nitrogen metabolism mtu00910
mtu00910Metabolism; Energy metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
- Clin Vaccine Immunol. 2009 Aug;16(8):1203-12. doi: 10.1128/CVI.00111-09. Epub 2009 Jun 24.
- Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.
- J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
- Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
- Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007.
- Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.
- J Exp Med. 2003 Sep 1;198(5):705-13. doi: 10.1084/jem.20030205.
- Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis.
- J Bacteriol. 2003 Dec;185(24):7247-56. doi: 10.1128/jb.185.24.7247-7256.2003.
- Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.
- Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7534-9. doi: 10.1073/pnas.121172498.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.