Rv1739c
- Type
- protein_coding
- Name
- Rv1739c
- Locus Name
-
Rv1739c
- Product
-
Probable sulphate-transport transmembrane protein ABC transporter
- Functional Category
-
Cell wall and cell processes
- Location
- 1965955..1967637 (- strand)
- Gene Length
- 1682 bp
- Nucleotides
-
ATGATTCCCACGATGACATCGGCCGGCTGGGCACCAGGGGTGGTGCAGTTCCGCGAATACCAACGGCGTTGGCTGCGCGGCGATGTCCTCGCCGGCCTGACCGTGGCCGCCTATCTGATCCCGCAAGCGATGGCGTATGCGACCGTGGCGGGCCTACCGCCGGCAGCCGGGCTGTGGGCGTCGATCGCGCCGCTTGCCATTTACGCACTGCTCGGATCGTCCCGGCAGCTTTCAATCGGCCCGGAATCCGCCACCGCCTTGATGACGGCGGCCGTGCTCGCTCCGATGGCCGCCGGGGATCTTCGACGCTATGCCGTTCTGGCGGCAACCCTCGGATTGCTAGTCGGCCTTATCTGCCTACTCGCTGGCACGGCGCGACTAGGTTTCCTCGCCAGCCTGCGATCGCGGCCGGTGCTCGTCGGATACATGGCCGGCATCGCGCTTGTCATGATCTCCAGCCAACTCGGCACTATCACCGGCACCTCGGTCGAAGGCAACGAATTCTTCAGCGAAGTACACTCTTTCGCGACTAGCGTCACGCGAGTTCACTGGCCGACTTTTGTGTTAGCCATGTCTGTCCTAGCGCTGCTAACTATGCTCACGCGGTGGGCGCCGCGCGCCCCCGGACCGATCATCGCGGTTCTTGCGGCCACGATGCTAGTGGCCGTTATGTCCTTGGATGCCAAAGGTATTGCGATTGTGGGTCGGATACCTTCCGGTCTGCCGACGCCGGGTGTGCCGCCCGTTTCGGTGGAAGACTTGCGGGCACTGATCATTCCGGCTGCCGGGATCGCGATTGTTACCTTCACCGACGGTGTGTTGACCGCACGCGCCTTCGCCGCTCGTCGAGGTCAGGAAGTCAATGCCAACGCCGAGCTGCGCGCGGTCGGGGCCTGCAACATCGCCGCCGGGCTGACACACGGTTTTCCGGTGAGTTCCAGCAGCAGCCGTACCGCCCTCGCCGACGTCGTCGGTGGCCGCACCCAGCTGTACTCGCTGATCGCGTTGGGGCTTGTTGTCATCGTGATGGTTTTCGCGAGTGGGCTGCTGGCCATGTTTCCGATCGCCGCTCTGGGCGCTTTGGTGGTATATGCCGCGCTACGCTTGATCGACTTGTCAGAATTCCGGCGACTGGCGCGGTTTCGGCGCAGCGAACTCATGCTGGCACTAGCCACCACAGCAGCCGTGTTAGGCCTAGGAGTGTTCTATGGAGTCCTCGCCGCGGTTGCCCTGTCCATCCTCGAACTGCTTCGTCGGGTCGCACATCCGCATGACAGCGTTCTCGGGTTCGTGCCGGGCATTGCCGGCATGCACGACATCGATGACTATCCGCAGGCCAAGCGCGTGCCCGGGCTGGTGGTGTATCGCTATGACGCGCCGTTGTGCTTCGCCAATGCCGAAGACTTCCGCAGGCGAGCACTGACCGTGGTCGATCAGGATCCGGGGCAAGTCGAGTGGTTCGTACTCAACGCCGAATCCAATGTGGAGGTCGACCTGACTGCGCTGGATGCGCTCGACCAACTCCGCACCGAGCTGCTGCGTCGGGGAATAGTGTTCGCCATGGCCCGGGTCAAACAAGACTTGCGTGAATCACTCAGGGCCGCCAGTCTTCTCGATAAGATTGGCGAAGACCATATCTTTATGACATTGCCTACCGCAGTGCAGGCGTTCCGTCGGCGCTA
- Drug Resistance
- Mutations
- Function
- Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein. {ECO:0000269|PubMed:18255326}.
- Family
-
SLC26A/SulP transporter (TC 2.A.53) family
- GO
-
- guanyl nucleotide binding GO:0019001 molecular_function
- anion:anion antiporter activity GO:0015301 molecular_function
- integral component of plasma membrane GO:0005887 cellular_component
- plasma membrane GO:0005886 cellular_component
- secondary active sulfate transmembrane transporter activity GO:0008271 molecular_function
- sulfate assimilation GO:0000103 biological_process
- InterPro
Summary
- Name
- Probable sulfate transporter Rv1739c
- Family
- SLC26A/SulP transporter (TC 2.A.53) family
- Protein Sequence
-
MIPTMTSAGWAPGVVQFREYQRRWLRGDVLAGLTVAAYLIPQAMAYATVAGLPPAAGLWASIAPLAIYALLGSSRQLSIGPESATALMTAAVLAPMAAGDLRRYAVLAATLGLLVGLICLLAGTARLGFLASLRSRPVLVGYMAGIALVMISSQLGTITGTSVEGNEFFSEVHSFATSVTRVHWPTFVLAMSVLALLTMLTRWAPRAPGPIIAVLAATMLVAVMSLDAKGIAIVGRIPSGLPTPGVPPVSVEDLRALIIPAAGIAIVTFTDGVLTARAFAARRGQEVNANAELRAVGACNIAAGLTHGFPVSSSSSRTALADVVGGRTQLYSLIALGLVVIVMVFASGLLAMFPIAALGALVVYAALRLIDLSEFRRLARFRRSELMLALATTAAVLGLGVFYGVLAAVALSILELLRRVAHPHDSVLGFVPGIAGMHDIDDYPQAKRVPGLVVYRYDAPLCFANAEDFRRRALTVVDQDPGQVEWFVLNAESNVEVDLTALDALDQLRTELLRRGIVFAMARVKQDLRESLRAASLLDKIGEDHIFMTLPTAVQAFRRR
- Mass
- 59,367 Da
- Length
- 560 Aa
Rv1739c doesn't seem to be a targeted by any drug.
Rv1739c doesn't seem to be involved in any pathway.
- NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis.
- Biomol NMR Assign. 2009 Jun;3(1):99-102. doi: 10.1007/s12104-009-9150-z. Epub 2009 Mar 14.
- Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
- Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar;149(3):255-66. doi: 10.1016/j.cbpa.2007.12.005. Epub 2007 Dec 23.
- Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.
- Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7534-9. doi: 10.1073/pnas.121172498.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.