Gene - combatTB X

Rv1747

Type: protein_coding
Name: Rv1747
Locus Name: Rv1747
Product: Probable conserved transmembrane ATP-binding protein ABC transporter
Functional Category: Cell wall and cell processes
Location: 1973630..1976227 (+ strand)
Gene Length: 2597 bp
Nucleotides: TGCCGATGAGCCAACCAGCCGCCCCGCCCGTGTTGACCGTGCGGTATGAGGGATCGGAGCGCACGTTCGCCGCAGGACACGATGTCGTCGTCGGGCGTGACCTGCGCGCGGATGTCCGCGTCGCACACCCCCTGATCTCCCGGGCACACCTGCTGCTGCGATTCGACCAGGGTCGCTGGGTCGCCATTGACAATGGCAGCCTCAATGGGCTCTACCTCAATAACCGTCGGGTGCCAGTCGTGGACATCTACGATGCCCAGCGAGTCCATATCGGAAACCCCGACGGTCCGGCGCTGGACTTCGAAGTGGGCCGCCACCGGGGTTCGGCCGGGCGACCACCCCAGACGACGTCGATACGCCTGCCCAACCTGTCCGCGGGAGCGTGGCCCACCGACGGCCCGCCGCAGACCGGCACGCTCGGCTCCGGCCAGCTACAACAGCTTCCACCGGCCACCACCCGGATACCCGCCGCTCCGCCATCGGGACCACAGCCGCGATACCCCACCGGTGGGCAACAGTTGTGGCCACCCAGCGGACCGCAACGGGCGCCGCAGATTTACCGGCCACCCACGGCCGCACCGCCGCCGGCGGGTGCCCGCGGCGGAACTGAGGCGGGAAACCTCGCGACATCGATGATGAAGATCCTGCGGCCAGGCAGGTTGACGGGGGAGTTGCCGCCCGGTGCCGTCAGGATCGGCCGGGCGAACGACAACGACATCGTCATTCCCGAGGTGTTGGCCTCACGTCACCACGCCACCCTGGTCCCGACGCCTGGCGGCACGGAGATTCGGGACAACCGCAGCATCAATGGCACCTTCGTCAACGGCGCCCGGGTCGACGCGGCGCTGCTGCACGACGGCGACGTCGTGACCATCGGCAACATCGACCTCGTCTTCGCCGACGGCACCCTGGCGCGCCGTGAAGAGAACCTGCTGGAGACCCGCGTCGGCGGCCTCGACGTGCGCGGGGTGACCTGGACCATCGATGGCGACAAGACACTGCTGGACGGCATCTCGTTGACGGCGCGCCCCGGTATGCTCACCGCCGTCATCGGTCCGTCGGGCGCTGGCAAGTCGACACTTGCCCGGTTGGTGGCTGGGTATACGCACCCGACGGATGGCACGGTGACGTTCGAGGGCCACAACGTTCACGCCGAATATGCCTCGCTGCGCAGCAGGATCGGCATGGTGCCACAGGACGACGTGGTGCACGGTCAGCTGACCGTGAAACACGCGCTGATGTATGCCGCCGAACTACGGCTGCCGCCGGACACCACCAAAGATGACCGCACCCAGGTAGTTGCCCGGGTGCTCGAAGAACTCGAGATGTCCAAGCACATCGACACCAGGGTCGACAAGCTGTCGGGTGGTCAACGCAAGCGGGCGTCGGTGGCGCTTGAGCTGTTGACCGGGCCGTCACTGCTGATCCTCGACGAGCCGACATCCGGCCTAGATCCTGCGCTGGACCGGCAGGTCATGACCATGCTGCGGCAGTTGGCCGACGCCGGTCGGGTGGTGCTCGTGGTTACCCACTCACTGACCTACCTGGACGTCTGTGACCAGGTTCTGCTGTTGGCCCCCGGCGGCAAGACCGCGTTCTGTGGGCCACCGACTCAGATTGGTCCGGTCATGGGGACCACGAACTGGGCCGACATCTTCAGCACCGTCGCCGACGACCCAGACGCGGCCAAAGCCCGCTACCTGGCGCGGACGGGTCCGACCCCACCACCGCCACCGGTCGAGCAACCCGCCGAACTGGGCGATCCGGCCCATACCAGCTTGTTTCGGCAGTTCTCCACGATCGCGCGGCGACAGTTGCGATTGATCGTTTCCGACCGAGGTTACTTCGTCTTTCTGGCGCTGTTGCCGTTCATCATGGGTGCGCTGTCCATGTCGGTACCGGGCGACGTGGGCTTCGGGTTTCCCAACCCGATGGGTGACGCGCCCAACGAGCCCGGCCAGATCCTAGTGTTGCTGAATGTCGGTGCGGTCTTCATGGGGACCGCGCTGACCATTCGTGACCTCATCGGTGAGCGAGCCATCTTCCGGCGCGAACAGGCAGTCGGCCTGTCCACTACCGCCTACCTGATCGCGAAGGTCTGTGTCTACACCGTGCTCGCGGTGGTTCAGTCGGCGATTGTGACGGTGATCGTCCTGGTCGGCAAGGGCGGTCCGACTCAGGGTGCCGTAGCGTTGAGCAAGCCAGATCTGGAGCTGTTCGTTGATGTCGCGGTGACCTGTGTCGCCTCGGCGATGCTCGGATTGGCGCTGTCGGCGATCGCCAAGTCCAACGAACAGATCATGCCCCTGCTGGTCGTGGCGGTCATGTCGCAGCTGGTGTTCTCCGGAGGCATGATTCCGGTCACCGGACGTGTTCCCCTTGACCAGATGTCCTGGGTCACACCGGCGAGATGGGGTTTCGCGGCGTCGGCCGCTACGGTCGACCTGATCAAATTGGTGCCCGGTCCGCTGACCCCGAAGGATTCGCATTGGCATCACACCGCCAGCGCGTGGTGGTTCGACATGGCCATGCTGGTAGCGCTCAGCGTTATCTACGTCGGCTTTGTGCGCTGGAAGATTCGCCTCAAGGCGTGCTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence. {ECO:0000269|PubMed:15135525, ECO:0000269|PubMed:16040957}.

Family

ABC transporter superfamily; ABC-2 integral membrane protein family

GO

transmembrane transport GO:0055085 biological_process
integral component of membrane GO:0016021 cellular_component
plasma membrane GO:0005886 cellular_component
ATPase-coupled transmembrane transporter activity GO:0042626 molecular_function
cytosol GO:0005829 cellular_component
ATP binding GO:0005524 molecular_function
cell wall GO:0005618 cellular_component

InterPro

UniProt: O65934
GenBank: Rv1747
EnsemblBacteria: Rv1747
Mycobrowser: Rv1747

Summary

Name: ABC transporter ATP-binding/permease protein Rv1747 (EC 3.6.3.-)
Family: ABC transporter superfamily; ABC-2 integral membrane protein family
Protein Sequence: MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHPLISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFEVGRHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPPSGPQPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRPGRLTGELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNGARVDAALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTLLDGISLTARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRSRIGMVPQDDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTRVDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKARYLARTGPTPPPPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPFIMGALSMSVPGDVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIFRREQAVGLSTTAYLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELFVDVAVTCVASAMLGLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMSWVTPARWGFAASAATVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFVRWKIRLKAC
Mass: 92,153 Da
Length: 865 Aa

Rv1747 doesn't seem to be a targeted by any drug.

Rv1747 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.: J Biol Chem. 2011 Jul 22;286(29):26198-209. doi: 10.1074/jbc.M111.246132. Epub 2011 May 26.
Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains.: Protein Sci. 2005 Jul;14(7):1918-21. doi: 10.1110/ps.051413405.
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.: Infect Immun. 2005 Aug;73(8):4471-7. doi: 10.1128/IAI.73.8.4471-4477.2005.
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.: FEMS Microbiol Lett. 2004 May 15;234(2):215-23. doi: 10.1016/j.femsle.2004.03.033.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.