Gene - combatTB X

eccB5

Type: protein_coding
Name: eccB5
Locus Name: Rv1782
Product: ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein.
Functional Category: Cell wall and cell processes
Location: 2017740..2019260 (+ strand)
Gene Length: 1520 bp
Nucleotides: TGGCTGAAGAGAGCCGCGGGCAGCGGGGGTCGGGGTATGGCCTTGGGTTGTCCACGCGGACCCAGGTAACCGGTTATCAGTTCCTGGCGCGTCGAACCGCAATGGCGTTGACACGCTGGCGTGTGCGTATGGAGATTGAGCCGGGTCGGCGGCAGACGTTGGCGGTGGTGGCGTCGGTGTCGGCGGCGTTGGTGATCTGTCTGGGGGCGCTGTTGTGGTCGTTCATCAGCCCGTCCGGCCAGTTGAATGAGTCGCCGATCATCGCAGACCGCGATTCCGGTGCGCTCTATGTCCGTGTCGGTGACAGGTTGTACCCGGCGCTGAATTTGGCATCGGCACGGCTGATCACCGGGCGGCCGGACAACCCGCACCTGGTTCGGTCAAGCCAGATTGCCACCATGCCGCGCGGTCCGCTGGTGGGTATCCCGGGTGCGCCGTCATCGTTCTCGCCAAAGAGTCCACCCGCGTCGTCTTGGCTGGTCTGCGACACGGTAGCGACCTCGTCAAGCATCGGGTCGCTGCAAGGCGTGACGGTGACGGTCATCGACGGGACCCCGGACCTTACCGGTCACCGGCAGATTTTGAGTGGATCGGACGCGGTAGTGCTGCGCTACGGCGGAGATGCGTGGGTCATCCGGGAGGGGCGCCGGTCACGAATCGAGCCGACGAATCGAGCGGTGTTGTTGCCGCTGGGGTTGACGCCGGAGCAGGTTAGCCAGGCGCGTCCGATGAGCCGGGCATTGTTCGACGCTTTGCCGGTCGGGCCCGAACTGTTGGTGCCGGAAGTGCCGAATGCGGGTGGTCCTGCGACGTTCCCGGGCGCTCCCGGACCGATCGGGACGGTAATCGTCACACCGCAAATCAGTGGACCACAACAGTATTCGTTGGTCCTGGGCGATGGAGTGCAAACGCTCCCGCCGTTGGTGGCCCAGATCCTGCAGAACGCTGGTAGTGCGGGCAACACCAAGCCGTTGACCGTGGAACCCTCAACGCTGGCCAAGATGCCGGTGGTGAATCGGTTGGATCTCTCTGCGTATCCGGACAATCCCCTGGAAGTGGTGGACATTCGCGAGCATCCGTCGACCTGTTGGTGGTGGGAGCGGACGGCCGGTGAAAACCGGGCCCGTGTGCGGGTCGTGTCCGGGCCTACCATTCCGGTCGCGGCGACCGAGATGAACAAGGTGGTGTCGTTGGTGAAGGCCGACACGAGTGGCCGCCAAGCCGATCAGGTCTACTTCGGCCCCGACCATGCGAACTTCGTGGCCGTCACCGGCAACAACCCGGGGGCCCAAACGTCCGAATCGCTATGGTGGGTGACCGATGCGGGCGCGCGGTTCGGGGTGGAGGACAGCAAAGAAGCGCGTGACGCGTTGGGGTTGACCCTGACGCCGAGCCTGGCGCCGTGGGTGGCGCTGCGGCTGCTGCCACAGGGCCCCACGCTGTCACGAGCGGACGCGTTGGTGGAGCACGACACGCTCCCAATGGACATGACCCCTGCAGAGTTGGTGGTACCGAAATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An ATPase (shown for residues 80-506) (PubMed:26396239). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462, ECO:0000269|PubMed:23284869}.

Family

EccB family

GO

cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
hydrolase activity GO:0016787 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

IPR007795

UniProt: P9WNQ9
GenBank: Rv1782
EnsemblBacteria: Rv1782
Mycobrowser: Rv1782

Summary

Name: ESX-5 secretion system ATPase EccB5 (EC 3.6.-.-) (ESX conserved component B5) (Type VII secretion system protein EccB5) (T7SS protein EccB5)
Family: EccB family
Protein Sequence: MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWRVRMEIEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGDRLYPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWLVCDTVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRSRIEPTNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAPGPIGTVIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAKMPVVNRLDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEMNKVVSLVKADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVEDSKEARDALGLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK
Mass: 53,721 Da
Length: 506 Aa

Rv1782 doesn't seem to be a targeted by any drug.

Rv1782 doesn't seem to be involved in any pathway.

Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.: FASEB J. 2015 Dec;29(12):4804-14. doi: 10.1096/fj.15-270843. Epub 2015 Sep 22.
The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability.: PLoS One. 2012;7(12):e52059. doi: 10.1371/journal.pone.0052059. Epub 2012 Dec 17.
Composition of the type VII secretion system membrane complex.: Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub 2012 Aug 27.
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.: Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.