eccC5
- Type
- protein_coding
- Name
- eccC5
- Locus Name
-
Rv1783
- Product
-
ESX conserved component EccC5. ESX-5 type VII secretion system protein.
- Functional Category
-
Cell wall and cell processes
- Location
- 2019257..2023432 (+ strand)
- Gene Length
- 4175 bp
- Nucleotides
-
TGAAGCGTGGTTTTGCCCGCCCGACACCGGAAAAGCCTCCGGTCATCAAGCCCGAGAATATTGTCCTATCGACACCGCTGAGCATTCCGCCGCCGGAGGGCAAGCCCTGGTGGCTGATTGTGGTTGGCGTCGTGGTGGTGGGCCTGCTGGGCGGCATGGTCGCCATGGTTTTCGCCAGCGGATCACACGTGTTCGGCGGCATCGGCTCGATCTTCCCGCTCTTCATGATGGTCGGGATCATGATGATGATGTTCCGCGGCATGGGCGGCGGCCAACAGCAAATGAGCCGGCCGAAATTGGACGCGATGCGCGCTCAGTTCATGTTGATGCTGGACATGCTGCGCGAGACGGCCCAAGAGTCGGCCGACAGCATGGACGCCAACTATCGGTGGTTCCACCCGGCGCCCAATACGTTGGCGGCCGCCGTGGGGTCACCCCGGATGTGGGAGCGCAAGCCCGACGGTAAGGACCTGAACTTCGGGGTTGTCCGCGTCGGCGTGGGAATGACGCGTCCCGAAGTGACCTGGGGTGAGCCGCAGAATATGCCGACCGACATCGAGCTGGAGCCGGTGACAGGTAAGGCGCTGCAGGAATTCGGGCGCTACCAAAGCGTCGTGTACAACCTGCCGAAAATGGTTTCGCTGCTGGTCGAACCCTGGTATGCGCTGGTCGGGGAACGCGAGCAGGTTCTGGGTTTGATGCGGGCGATCATCTGCCAGCTGGCGTTCTCCCACGGGCCTGACCATGTCCAGATGATCGTTGTCAGTTCCGATCTAGACCAATGGGACTGGGTGAAGTGGCTACCGCATTTCGGTGACTCGCGGCGGCACGACGCGGCGGGTAACGCGCGGATGGTCTACACCTCGGTTCGTGAGTTTGCCGCAGAGCAAGCCGAATTATTCGCGGGCCGTGGTTCTTTCACGCCTCGACACGCGAGTTCGTCGGCGCAGACCCCGACCCCGCACACCGTGATCATCGCCGACGTCGACGATCCGCAATGGGAGTACGTGATCAGCGCCGAGGGTGTCGACGGGGTGACGTTCTTCGACCTGACCGGCTCTTCGATGTGGACTGACATCCCGGAGCGGAAGCTGCAGTTCGACAAGACCGGCGTGATCGAGGCGCTGCCCCGCGACCGCGACACCTGGATGGTGATCGACGACAAGGCTTGGTTCTTCGCTCTCACCGACCAAGTCAGCATCGCCGAGGCAGAAGAGTTCGCGCAGAAGCTGGCGCAGTGGCGGCTGGCTGAGGCCTATGAAGAGATCGGCCAGCGGGTTGCCCACATTGGTGCCCGAGACATCTTGTCCTACTACGGGATTGACGATCCTGGCAACATCGACTTCGACTCGCTGTGGGCTAGCCGGACCGACACCATGGGACGGTCGCGATTGCGGGCGCCGTTCGGTAATCGCTCCGACAACGGCGAGCTGCTGTTCTTGGATATGAAATCGCTCGACGAAGGCGGCGACGGCCCGCACGGGGTCATGTCCGGGACGACCGGTTCCGGTAAGTCGACGTTGGTGCGAACCGTGATCGAATCGCTGATGCTCAGCCATCCGCCGGAGGAGTTGCAGTTCGTTTTGGCAGACCTCAAAGGTGGCTCGGCGGTCAAGCCGTTCGCGGGAGTGCCACACGTGTCGCGGATCATCACCGACCTCGAAGAAGACCAGGCGCTCATGGAGCGCTTTCTGGATGCGCTGTGGGGCGAGATCGCCCGCCGCAAAGCAATATGCGACAGCGCCGGTGTCGACGACGCCAAAGAGTACAACTCGGTGCGAGCCAGGATGCGTGCGCGCGGTCAGGACATGGCGCCGCTGCCGATGCTCGTGGTGGTCATCGACGAGTTCTACGAATGGTTCCGCATCATGCCGACGGCGGTCGACGTCCTCGACTCGATCGGCCGGCAGGGCCGCGCCTACTGGATTCACCTGATGATGGCGTCTCAGACCATCGAGAGCCGAGCCGAAAAGCTCATGGAGAACATGGGTTACCGCTTGGTGCTGAAAGCGCGTACCGCGGGAGCGGCGCAGGCGGCCGGGGTGCCCAACGCGGTGAATCTGCCCGCACAGGCCGGTCTGGGCTACTTCCGCAAGAGCCTCGAGGACATCATCCGATTCCAGGCGGAATTCCTGTGGCGGGACTACTTCCAACCCGGCGTCAGCATCGACGGCGAGGAAGCGCCTGCCTTAGTACACAGCATCGACTACATTCGCCCGCAATTGTTTACCAACTCGTTCACACCGCTGGAAGTTAGCGTGGGGGGTCCCGATATCGAGCCGGTAGTTGCCCAGCCCAACGGTGAGGTGCTCGAGTCGGACGACATTGAAGGCGGCGAGGACGAGGACGAAGAGGGGGTGCGCACCCCGAAGGTTGGGACGGTGATCATTGATCAGCTGCGCAAGATCAAGTTCGAGCCGTACCGGCTCTGGCAACCGCCACTAACCCAACCCGTCGCCATCGACGACTTGGTCAACCGGTTCCTCGGCCGCCCGTGGCACAAGGAGTACGGTTCGGCGTGCAATCTCGTGTTCCCGATCGGGATAATCGATCGCCCCTATAAGCATGACCAGCCACCGTGGACGGTTGACACCTCCGGGCCCGGTGCCAACGTGCTAATCCTGGGCGCCGGCGGTTCGGGCAAGACCACTGCGCTGCAGACACTCATCTGCTCAGCGGCACTGACTCACACCCCGCAGCAGGTTCAGTTCTACTGCCTGGCCTACAGCAGCACCGCGTTGACCACGGTCTCCCGCATCCCCCACGTGGGCGAGGTTGCCGGTCCCACCGATCCCTACGGTGTGCGCCGGACGGTGGCCGAGTTGCTGGCGCTGGTGCGCGAGCGCAAACGCAGCTTCCTGGAATGCGGAATCGCGTCGATGGAGATGTTCCGGCGCCGCAAGTTCGGCGGAGAGGCCGGGCCGGTACCCGACGACGGCTTCGGTGACGTCTACCTGGTGATCGATAACTACCGGGCCCTGGCCGAAGAAAACGAGGTGCTGATCGAGCAGGTGAACGTGATCATCAACCAGGGCCCCTCGTTCGGGGTGCACGTGGTGGTCACTGCCGACCGCGAATCGGAGCTGCGGCCGCCGGTGCGCAGCGGCTTCGGATCCCGTATCGAGCTGCGCTTGGCGGCGGTTGAGGACGCCAAGCTGGTGCGTTCTCGATTCGCCAAGGACGTTCCGGTCAAGCCGGGGCGCGGCATGGTTGCGGTCAACTACGTCCGCCTGGACAGCGACCCGCAGGCCGGCCTGCACACCCTGGTGGCTCGACCGGCGTTGGGCAGCACACCCGACAATGTCTTCGAGTGCGACAGCGTGGTCGCGGCGGTGAGCCGGCTCACCAGCGCCCAGGCTCCACCGGTGCGCCGGTTGCCGGCGCGGTTCGGCGTGGAACAGGTGCGGGAGCTGGCCTCGCGGGACACCCGCCAAGGCGTTGGCGCTGGCGGAATCGCCTGGGCGATATCGGAATTGGATCTGGCGCCGGTTTATCTGAATTTCGCCGAGAATTCGCACCTGATGGTGACTGGTCGACGCGAATGTGGCCGCACCACCACGCTGGCCACCATCATGTCCGAAATCGGGCGGCTCTACGCGCCGGGCGCCAGTAGCGCACCGCCTCCCGCCCCCGGGCGGCCCTCTGCGCAGGTATGGCTGGTCGACCCGCGCCGTCAGCTGCTGACCGCGCTCGGTTCGGACTATGTGGAGCGGTTCGCCTACAACCTCGACGGGGTGGTGGCGATGATGGGTGAACTTGCGGCGGCGTTGGCCGGTCGTGAGCCGCCACCGGGCCTGTCCGCCGAAGAGTTGTTGTCGCGGTCGTGGTGGAGCGGCCCAGAAATCTTCCTGATCGTCGACGACATCCAGCAGCTGCCGCCGGGCTTCGATTCACCGTTGCACAAGGCTGTTCCGTTTGTGAACAGGGCCGCCGATGTCGGCTTGCATGTGATCGTCACGCGCACCTTCGGTGGTTGGTCGTCAGCCGGCAGCGACCCGATGTTGCGGGCCCTGCATCAGGCCAATGCGCCACTGCTGGTGATGGACGCCGATCCCGACGAGGGCTTCATTCGCGGCAAGATGAAGGGCGGCCCGCTGCCCCGCGGTCGAGGCCTGTTGATGGCAGAAGACACCGGTGTGTTCGTCCAAGTGGCAGCCACCGAGGTGCGTCGGTAG
- Drug Resistance
- Mutations
- Function
- Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462, ECO:0000269|PubMed:23284869}.
- Family
-
Unknown
- GO
-
- integral component of membrane GO:0016021 cellular_component
- plasma membrane GO:0005886 cellular_component
- DNA binding GO:0003677 molecular_function
- ATP binding GO:0005524 molecular_function
- cell wall GO:0005618 cellular_component
- InterPro
Summary
- Name
- ESX-5 secretion system protein EccC5 (ESX conserved component C5) (Type VII secretion system protein EccC5) (T7SS protein EccC5)
- Family
- Unknown
- Protein Sequence
-
MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGVVVVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDAMRAQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNFGVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVEPWYALVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRRHDAAGNARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQWEYVISAEGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWFFALTDQVSIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFDSLWASRTDTMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLMLSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLDALWGEIARRKAICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIMPTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGLGYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRPQLFTNSFTPLEVSVGGPDIEPVVAQPNGEVLESDDIEGGEDEDEEGVRTPKVGTVIIDQLRKIKFEPYRLWQPPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKHDQPPWTVDTSGPGANVLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTALTTVSRIPHVGEVAGPTDPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGEAGPVPDDGFGDVYLVIDNYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELRPPVRSGFGSRIELRLAAVEDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHTLVARPALGSTPDNVFECDSVVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQGVGAGGIAWAISELDLAPVYLNFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGASSAPPPAPGRPSAQVWLVDPRRQLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREPPPGLSAEELLSRSWWSGPEIFLIVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVTRTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVFVQVAATEVRR
- Mass
- 152,740 Da
- Length
- 1391 Aa
Rv1783 doesn't seem to be a targeted by any drug.
Rv1783 doesn't seem to be involved in any pathway.
- The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability.
- PLoS One. 2012;7(12):e52059. doi: 10.1371/journal.pone.0052059. Epub 2012 Dec 17.
- Composition of the type VII secretion system membrane complex.
- Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub 2012 Aug 27.
- Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
- Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- Systematic genetic nomenclature for type VII secretion systems.
- PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.