Gene - combatTB X

PPE26

Type: protein_coding
Name: PPE26
Locus Name: Rv1789
Product: PPE family protein PPE26
Functional Category: Pe/ppe
Location: 2026790..2027971 (+ strand)
Gene Length: 1181 bp
Nucleotides: TGGATTTTGGGGCGTTGCCGCCGGAGGTCAATTCGGTGCGGATGTATGCCGGTCCTGGCTCGGCACCAATGGTCGCTGCGGCGTCGGCCTGGAACGGGTTGGCCGCGGAGCTGAGTTCGGCGGCCACCGGTTATGAGACGGTGATCACTCAGCTCAGCAGTGAGGGGTGGCTAGGTCCGGCGTCAGCGGCGATGGCCGAGGCAGTTGCGCCGTATGTGGCGTGGATGAGTGCCGCTGCGGCGCAAGCCGAGCAGGCGGCCACACAGGCCAGGGCCGCCGCGGCCGCTTTTGAGGCGGCGTTTGCCGCGACGGTGCCTCCGCCGTTGATCGCGGCCAACCGGGCTTCGTTGATGCAGCTGATCTCGACGAATGTCTTTGGTCAGAACACCTCGGCGATCGCGGCCGCCGAAGCTCAGTACGGCGAGATGTGGGCCCAAGACTCCGCGGCGATGTATGCCTACGCGGGCAGTTCGGCGAGCGCCTCGGCGGTCACGCCGTTTAGCACGCCGCCGCAGATTGCCAACCCGACCGCTCAGGGTACGCAGGCCGCGGCCGTGGCCACCGCCGCCGGTACCGCCCAGTCGACGCTGACGGAGATGATCACCGGGCTACCCAACGCGCTGCAAAGCCTCACCTCACCTCTGTTGCAGTCGTCTAACGGTCCGCTGTCGTGGCTGTGGCAGATCTTGTTCGGCACGCCCAATTTCCCCACCTCAATTTCGGCACTGCTGACCGACCTGCAGCCCTACGCGAGCTTCTTCTATAACACCGAGGGCCTGCCGTACTTCAGCATCGGCATGGGCAACAACTTCATTCAGTCGGCCAAGACCCTGGGATTGATCGGCTCGGCGGCACCGGCTGCGGTCGCGGCTGCTGGGGATGCCGCCAAGGGCTTGCCTGGACTGGGCGGGATGCTCGGTGGCGGGCCGGTGGCGGCGGGTCTGGGCAATGCGGCTTCGGTTGGCAAGCTGTCGGTGCCGCCGGTGTGGAGTGGACCGTTGCCCGGGTCGGTGACTCCGGGGGCTGCTCCGCTACCGGTGAGTACGGTCAGTGCCGCCCCGGAGGCGGCGCCCGGAAGCCTGTTGGGCGGCCTGCCGCTAGCTGGTGCGGGCGGGGCCGGCGCGGGTCCACGCTACGGATTCCGTCCCACCGTCATGGCTCGCCCACCCTTCGCCGGATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Probably plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Stimulates macrophage activation by augmenting pro-inflammatory cytokine production (TNF-alpha, IL-6 and IL-12p40) and the expression of cell surface molecules (CD80, CD86, MHC class I and II). Also participates in adaptive immunity by directing Th1-polarised immune responses. {ECO:0000269|PubMed:26439698}.

Family

Mycobacterial PPE family

GO

pathogenesis GO:0009405 biological_process

InterPro

UniProt: Q79FK6
GenBank: Rv1789
EnsemblBacteria: Rv1789
Mycobrowser: Rv1789

Summary

Name: PPE family protein PPE26
Family: Mycobacterial PPE family
Protein Sequence: MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAATQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQYGEMWAQDSAAMYAYAGSSASASAVTPFSTPPQIANPTAQGTQAAAVATAAGTAQSTLTEMITGLPNALQSLTSPLLQSSNGPLSWLWQILFGTPNFPTSISALLTDLQPYASFFYNTEGLPYFSIGMGNNFIQSAKTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAAPGSLLGGLPLAGAGGAGAGPRYGFRPTVMARPPFAG
Mass: 38,589 Da
Length: 393 Aa

Rv1789 doesn't seem to be a targeted by any drug.

Rv1789 doesn't seem to be involved in any pathway.

PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response.: Oncotarget. 2015 Nov 17;6(36):38517-37. doi: 10.18632/oncotarget.5956.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.