Rv1794
- Type
- protein_coding
- Name
- Rv1794
- Locus Name
-
Rv1794
- Product
-
Conserved protein
- Functional Category
-
Conserved hypotheticals
- Location
- 2031066..2031968 (+ strand)
- Gene Length
- 902 bp
- Nucleotides
-
TGGATCAACAGAGTACCCGCACCGACATCACCGTCAACGTCGACGGCTTCTGGATGCTTCAGGCGCTACTGGATATCCGCCACGTTGCGCCTGAGTTACGTTGCCGGCCGTACGTCTCCACCGATTCCAATGACTGGCTAAACGAGCACCCGGGGATGGCGGTCATGCGCGAGCAGGGCATTGTCGTCAACGACGCGGTCAACGAACAGGTCGCTGCCCGGATGAAGGTGCTTGCCGCACCTGATCTTGAAGTCGTCGCCCTGCTGTCACGCGGCAAGTTGCTGTACGGGGTCATAGACGACGAGAACCAGCCGCCGGGTTCGCGTGACATCCCTGACAATGAGTTCCGGGTGGTGTTGGCCCGGCGAGGCCAGCACTGGGTGTCGGCGGTACGGGTTGGCAATGACATCACCGTCGATGACGTGACGGTCTCGGATAGCGCCTCGATCGCCGCACTGGTAATGGACGGTCTGGAGTCGATTCACCACGCCGACCCAGCCGCGATCAACGCGGTCAACGTGCCAATGGAGGAGATGCTAGAGGCAACGAAGTCGTGGCAGGAATCGGGGTTTAACGTCTTCTCCGGCGGAGATCTGCGCCGAATGGGCATCAGTGCCGCGACGGTGGCCGCGCTGGGGCAGGCGTTGTCGGATCCCGCGGCCGAGGTCGCAGTGTATGCGCGACAGTACCGAGACGACGCCAAGGGCCCCAGCGCCTCGGTGTTGTCGCTGAAAGACGGCTCCGGTGGACGCATCGCGCTGTATCAGCAGGCGCGAACGGCAGGTTCCGGCGAGGCGTGGCTGGCTATCTGCCCGGCTACCCCGCAGTTGGTGCAAGTAGGAGTGAAGACCGTTTTGGATACACTGCCCTACGGCGAGTGGAAAACACACAGCAGAGTATGA
- Drug Resistance
- Mutations
- Function
- Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000269|PubMed:25155747}.
- Family
-
EspG family
- GO
-
- cell wall GO:0005618 cellular_component
- plasma membrane GO:0005886 cellular_component
- cytoplasm GO:0005737 cellular_component
- InterPro
4KXR
- Name
- ESX-5 secretion-associated protein EspG5
- Family
- EspG family
- Protein Sequence
-
MDQQSTRTDITVNVDGFWMLQALLDIRHVAPELRCRPYVSTDSNDWLNEHPGMAVMREQGIVVNDAVNEQVAARMKVLAAPDLEVVALLSRGKLLYGVIDDENQPPGSRDIPDNEFRVVLARRGQHWVSAVRVGNDITVDDVTVSDSASIAALVMDGLESIHHADPAAINAVNVPMEEMLEATKSWQESGFNVFSGGDLRRMGISAATVAALGQALSDPAAEVAVYARQYRDDAKGPSASVLSLKDGSGGRIALYQQARTAGSGEAWLAICPATPQLVQVGVKTVLDTLPYGEWKTHSRV
- Mass
- 32,400 Da
- Length
- 300 Aa
Summary
Rv1794 doesn't seem to be a targeted by any drug.
Rv1794 doesn't seem to be involved in any pathway.
- Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion.
- Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14758-63. doi: 10.1073/pnas.1409345111. Epub 2014 Oct 1.
- Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.
- Mol Microbiol. 2014 Oct;94(2):367-82. doi: 10.1111/mmi.12770. Epub 2014 Sep 15.
- Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
- Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.