Gene - combatTB X

eccD5

Type: protein_coding
Name: eccD5
Locus Name: Rv1795
Product: ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein.
Functional Category: Cell wall and cell processes
Location: 2032240..2033751 (+ strand)
Gene Length: 1511 bp
Nucleotides: TGACCGCAGTAGCTGACGCACCTCAGGCTGACATTGAGGGTGTGGCATCGCCCCAGGCTGTCGTCGTGGGCGTCATGGCCGGCGAAGGCGTCCAGATCGGCGTCCTGCTGGATGCCAACGCCCCAGTTTCGGTGATGACCGACCCGCTGCTGAAAGTGGTTAATAGTCGGCTCAGAGAGCTCGGTGAGGCTCCACTGGAAGCCACTGGACGCGGCCGATGGGCGCTGTGTCTGGTGGACGGCGCGCCGTTGCGTGCTACCCAGTCGCTGACCGAACAAGACGTCTATGACGGCGACCGGCTGTGGATTCGGTTCATCGCAGACACCGAACGTCGCTCCCAAGTCATCGAACATATCTCCACCGCAGTCGCCTCGGATCTCAGCAAGCGGTTCGCCAGGATCGACCCGATCGTTGCTGTGCAGGTCGGGGCGTCGATGGTGGCGACCGGGGTTGTTCTTGCCACCGGGGTGCTCGGCTGGTGGCGCTGGCATCACAACACCTGGTTGACCACCATCTACACCGCGGTGATTGGTGTGCTGGTGCTGGCGGTCGCCATGTTGCTGTTGATGCGTGCCAAGACGGACGCGGATCGACGCGTCGCCGACATCATGCTGATGAGCGCGATCATGCCCGTGACGGTGGCGGCGGCAGCGGCCCCGCCCGGCCCGGTGGGCTCCCCGCAGGCCGTGTTGGGCTTCGGAGTGCTGACCGTCGCTGCGGCCCTGGCCCTGCGGTTCACCGGTCGCCGCCTGGGGATTTACACCACAATCGTCATCATCGGTGCGCTGACAATGCTTGCAGCCTTGGCGCGGATGGTCGCGGCCACAAGCGCGGTGACGCTGTTGTCGTCCTTGTTGTTGATTTGCGTAGTGGCCTACCACGCGGCGCCGGCACTGTCTCGGCGGCTGGCCGGCATCCGACTGCCGGTGTTCCCGTCCGCCACCAGCCGGTGGGTCTTCGAGGCTCGGCCCGACCTACCGACCACCGTGGTGGTGTCCGGTGGCAGCGCACCGGTCTTGGAAGGGCCGTCATCGGTGCGTGATGTGCTGCTGCAAGCTGAGCGCGCTCGGTCGTTCTTGAGCGGCCTGCTAACGGGACTTGGCGTGATGGTGGTGGTGTGCATGACATCGTTGTGCGACCCGCACACCGGGCAACGTTGGCTGCCGCTGATACTGGCCGGATTTACCTCGGGCTTCCTGCTGTTGCGGGGCCGCTCCTACGTCGACCGTTGGCAGTCGATTACCCTGGCCGGAACTGCGGTGATCATCGCTGCTGCGGTGTGTGTGCGGTACGCGCTGGAATTGTCCTCGCCGTTGGCTGTGTCCATTGTCGCCGCGATCCTGGTGCTGCTGCCGGCGGCGGGCATGGCAGCTGCTGCACATGTGCCCCACACCATCTACAGTCCGCTATTCCGCAAGTTTGTGGAATGGATTGAATACCTCTGCCTGATGCCGATCTTCCCGCTGGCGTTGTGGTTGATGAACGTCTATGCAGCGATTCGGTACCGGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}.

Family

EccD/Snm4 family

GO

plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WNP9
GenBank: Rv1795
EnsemblBacteria: Rv1795
Mycobrowser: Rv1795

Summary

Name: ESX-5 secretion system protein EccD5 (ESX conserved component D5) (Type VII secretion system protein EccD5) (T7SS protein EccD5)
Family: EccD/Snm4 family
Protein Sequence: MTAVADAPQADIEGVASPQAVVVGVMAGEGVQIGVLLDANAPVSVMTDPLLKVVNSRLRELGEAPLEATGRGRWALCLVDGAPLRATQSLTEQDVYDGDRLWIRFIADTERRSQVIEHISTAVASDLSKRFARIDPIVAVQVGASMVATGVVLATGVLGWWRWHHNTWLTTIYTAVIGVLVLAVAMLLLMRAKTDADRRVADIMLMSAIMPVTVAAAAAPPGPVGSPQAVLGFGVLTVAAALALRFTGRRLGIYTTIVIIGALTMLAALARMVAATSAVTLLSSLLLICVVAYHAAPALSRRLAGIRLPVFPSATSRWVFEARPDLPTTVVVSGGSAPVLEGPSSVRDVLLQAERARSFLSGLLTGLGVMVVVCMTSLCDPHTGQRWLPLILAGFTSGFLLLRGRSYVDRWQSITLAGTAVIIAAAVCVRYALELSSPLAVSIVAAILVLLPAAGMAAAAHVPHTIYSPLFRKFVEWIEYLCLMPIFPLALWLMNVYAAIRYR
Mass: 53,435 Da
Length: 503 Aa

Rv1795 doesn't seem to be a targeted by any drug.

Rv1795 doesn't seem to be involved in any pathway.

Composition of the type VII secretion system membrane complex.: Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub 2012 Aug 27.
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.: Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.