Gene - combatTB X

eccA5

Type: protein_coding
Name: eccA5
Locus Name: Rv1798
Product: ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Functional Category: Cell wall and cell processes
Location: 2036700..2038532 (+ strand)
Gene Length: 1832 bp
Nucleotides: TGACACGCCCGCAGGCCGCCGCCGAAGATGCCCGCAACGCCATGGTCGCCGGTCTGCTGGCATCGGGGATCTCCGTCAATGGACTGCAGCCCAGCCATAACCCGCAGGTGGCCGCCCAAATGTTCACCACGGCGACCAGGCTGGATCCCAAGATGTGTGATGCCTGGCTGGCTCGGCTGCTGGCCGGCGACCAGAGCATCGAAGTGCTCGCCGGCGCATGGGCTGCGGTGCGGACTTTCGGCTGGGAAACCCGCCGCCTCGGCGTGACGGATCTGCAGTTCCGCCCCGAGGTGTCCGACGGGCTATTCCTGCGACTGGCGATTACCAGCGTAGATTCGCTGGCCTGCGCTTACGCGGCGGTCCTCGCCGAGGCCAAGCGTTACCAGGAGGCGGCAGAGCTGCTCGACGCCACCGATCCTCGCCATCCGTTCGACGCCGAGCTGGTGAGTTACGTGCGGGGCGTGCTGTACTTCCGCACCAAACGCTGGCCTGACGTTCTTGCGCAGTTCCCCGAGGCAACGCAGTGGCGTCACCCCGAGCTAAAGGCCGCGGGGGCGGCGATGGCCACCACGGCGCTGGCGTCGCTCGGGGTGTTCGAAGAGGCCTTTCGGCGCGCTCAGGAAGCAATCGAAGGTGACCGGGTGCCGGGCGCGGCTAACATCGCCTTGTACACCCAAGGCATGTGCCTGCGGCACGTCGGCCGTGAGGAGGAAGCTGTCGAACTCCTGCGCCGCGTGTATTCGCGCGATGCGAAGTTCACCCCGGCCCGCGAGGCGCTGGATAACCCCAACTTTCGGCTGATCCTCACCGACCCGGAAACGATTGAGGCGCGCACAGATCCGTGGGATCCGGACAGTGCGCCAACCCGCGCTCAGACCGAGGCCGCCCGCCATGCCGAGATGGCCGCGAAGTACTTGGCCGAAGGGGATGCCGAGCTCAACGCGATGCTTGGCATGGAGCAGGCCAAGAAGGAGATCAAGCTCATCAAGTCGACGACGAAGGTGAATTTAGCGCGTGCCAAGATGGGGCTTCCGGTCCCGGTTACGTCGCGCCACACCTTGTTGCTCGGGCCGCCCGGTACCGGGAAGACTTCGGTCGCAAGGGCTTTCACCAAGCAGCTGTGCGGGTTGACAGTGCTGCGCAAGCCGCTGGTGGTGGAGACCAGCCGCACCAAGCTGTTGGGCCGGTACATGGCCGACGCCGAGAAGAACACCGAGGAGATGCTCGAAGGGGCGTTGGGCGGTGCGGTCTTCTTTGACGAGATGCACACTCTGCATGAGAAGGGCTACTCCCAGGGCGACCCGTACGGTAACGCGATCATCAACACGCTGCTGTTGTACATGGAAAATCACCGTGACGAGCTGGTGGTGTTTGGTGCGGGTTACGCCAAAGCGATGGAGAAAATGCTCGAGGTGAATCAGGGTCTGCGCCGGCGCTTTTCGACGGTGATCGAGTTCTTCAGCTACACCCCGCAGGAGCTGATCGCACTGACCCAGCTGATGGGTCGGGAGAACGAAGACGTGATCACTGAGGAAGAGTCTCAAGTGTTGTTGCCGTCGTATACCAAGTTCTACATGGAGCAGAGCTACTCCGAGGACGGCGACCTGATCCGCGGGATCGATCTGTTGGGCAATGCCGGCTTTGTGCGCAACGTGGTGGAGAAGGCCCGCGACCACCGTAGTTTCCGTTTGGACGATGAGGATCTCGACGCCGTACTGGCCAGCGATCTCACCGAATTCAGCGAGGATCAGCTGCGCCGATTCAAGGAGTTGACTCGCGAGGACCTGGCCGAAGGGCTGCGCGCTGCGGTCGCGGAGAAGAAGACGAAGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41 (PubMed:22340629, PubMed:22925462). EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity). {ECO:0000250|UniProtKB:P9WPH9, ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}.

Family

CbxX/CfxQ family

GO

ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: P9WPI1
GenBank: Rv1798
EnsemblBacteria: Rv1798
Mycobrowser: Rv1798

Summary

Name: ESX-5 secretion system protein EccA5 (ESX conserved component A5) (Type VII secretion system protein EccA5) (T7SS protein EccA5)
Family: CbxX/CfxQ family
Protein Sequence: MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK
Mass: 67,756 Da
Length: 610 Aa

Rv1798 doesn't seem to be a targeted by any drug.

Rv1798 doesn't seem to be involved in any pathway.

Composition of the type VII secretion system membrane complex.: Mol Microbiol. 2012 Oct;86(2):472-84. doi: 10.1111/j.1365-2958.2012.08206.x. Epub 2012 Aug 27.
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.: Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.