Gene - combatTB X

PPE29

Type: protein_coding
Name: PPE29
Locus Name: Rv1801
Product: PPE family protein PPE29
Functional Category: Pe/ppe
Location: 2042001..2043272 (+ strand)
Gene Length: 1271 bp
Nucleotides: TGGATTTCGGGTTGTTACCGCCGGAGATCAACTCAGGCAGGATGTATACGGGGCCGGGGCCGGGGCCCATGCTGGCCGCCGCGACAGCCTGGGACGGGCTGGCTGTTGAGCTGCACGCAACAGCGGCTGGCTACGCCTCGGAGCTATCGGCTTTGACCGGGGCATGGAGCGGTCCTTCGTCGACGTCCATGGCATCTGCAGCCGCACCCTATGTGGCATGGATGAGCGCCACCGCAGTGCATGCCGAGCTGGCGGGCGCGCAAGCCAGGTTGGCGATAGCTGCCTATGAAGCTGCGTTCGCTGCCACCGTGCCTCCGCCGGTGATCGCCGCTAATCGTGCCCAACTGATGGTGTTGATCGCGACGAACATCTTCGGGCAGAACACGCCGGCGATCATGATGACTGAGGCCCAATACATGGAAATGTGGGCGCAGGATGCCGCCGCGATGTACGGGTACGCCGGCTCGTCAGCGACCGCCTCGCGAATGACAGCGTTCACTGAGCCGCCGCAAACCACTAACCATGGTCAGTTGGGGGCCCAGTCCTCCGCCGTCGCACAAACCGCCGCCACCGCGGCCGGCGGCAACCTGCAATCGGCATTCCCGCAGCTGCTCTCCGCGGTTCCCCGCGCCCTGCAAGGCCTGGCATTGCCGACCGCATCACAGTCGGCATCGGCGACGCCGCAGTGGGTTACCGACCTGGGGAACCTGTCCACCTTCCTGGGCGGGGCGGTCACCGGCCCGTACACCTTTCCCGGGGTATTGCCTCCCTCCGGGGTGCCATACCTGTTAGGCATTCAGAGCGTCTTGGTAACCCAAAACGGGCAGGGGGTAAGCGCCTTGCTTGGCAAGATCGGGGGGAAACCAATCACCGGAGCGTTGGCTCCGCTGGCCGAATTTGCTTTGCATACACCAATTTTGGGTTCGGAGGGCTTGGGTGGTGGATCGGTTTCCGCGGGTATTGGCCGGGCAGGCTTGGTCGGAAAGCTATCGGTGCCTCAGGGCTGGACGGTGGCCGCCCCGGAGATCCCATCGCCGGCGGCGGCGTTGCAGGCGACGCGCCTGGCCGCCGCGCCGATTGCGGCCACCGACGGCGCGGGTGCGTTGCTCGGTGGCATGGCGCTGTCGGGCTTGGCTGGCCGCGCTGCCGCCGGTTCTACCGGCCACCCCATCGGCAGCGCCGCAGCACCCGCCGTCGGTGCCGCTGCCGCTGCCGTCGAGGACCTGGCCACCGAAGCCAACATCTTCGTGATACCGGCCATGGACGACTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Could be required for host endothelial-cell invasion and/or intracellular survival. {ECO:0000269|PubMed:16586367}.

Family

Mycobacterial PPE family

GO

cell wall GO:0005618 cellular_component

InterPro

UniProt: P9WI09
GenBank: Rv1801
EnsemblBacteria: Rv1801
Mycobrowser: Rv1801

Summary

Name: Uncharacterized PPE family protein PPE29
Family: Mycobacterial PPE family
Protein Sequence: MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVGAAAAAVEDLATEANIFVIPAMDD
Mass: 41,477 Da
Length: 423 Aa

Rv1801 doesn't seem to be a targeted by any drug.

Rv1801 doesn't seem to be involved in any pathway.

Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.: J Infect Dis. 2006 May 1;193(9):1287-95. doi: 10.1086/502631. Epub 2006 Mar 28.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.