Gene - combatTB X

Rv1812c

Type: protein_coding
Name: Rv1812c
Locus Name: Rv1812c
Product: Probable dehydrogenase
Functional Category: Intermediary metabolism and respiration
Location: 2054157..2055359 (- strand)
Gene Length: 1202 bp
Nucleotides: TTGACCCGGGTGGTGGTGATCGGCTCCGGGTTCGCGGGCCTGTGGGCGGCGCTCGGTGCGGCCCGACGACTCGACGAGCTCGCCGTCCTAGCGGGCACGGTCGACGTCATGGTGGTGAGCAACAAACCGTTTCATGATATCCGGGTTCGCAACTATGAGGCTGATCTGAGCGCCTGCCGCATCCCGCTCGGCGACGTGCTCGGCCCTGCCGGCGTTGCGCATGTCACCGCCGAGGTGACCGCGATCGACGCCGACGGCCGCCGCGTCACCACGTCGACCGGTGCCTCATATAGCTATGACCGACTGGTCCTCGCGTCGGGCAGTCACGTGGTCAAACCCGCGTTGCCAGGACTGGCAGAGTTCGGTTTTGATGTCGACACGTACGACGGCGCGGTCAGGCTACAGCAGCATCTGCAAGGACTGGCCGGCGGGCCGCTGACATCGGCGGCGGCAACCGTCGTGGTCGTCGGTGCCGGGCTGACCGGTATCGAGACGGCCTGCGAGTTGCCGGGCCGACTGCACGCGTTGTTCGCCCGTGGTGATGGTGTCACCCCCCGCGTGGTACTCATCGACCACAACCCCTTCGTCGGCTCCGATATGGGTTTATCGGCGCGGCCGGTGATCGAACAGGCGCTGTTGGACAACGGCGTCGAGACCAGAACCGGCGTGAGCGTTGCCGCCGTCAGCCCGGGCGGTGTAACGCTGTCATCGGGGGAACGGCTGGCAGCGGCCACCGTGGTGTGGTGCGCCGGCATGCGGGCCAGCCGCCTGACCGAGCAGCTGCCGGTAGCCCGTGATCGGCTGGGACGCCTGCAAGTCGACGACTACCTGCGGGTGATCGGGGTGCCTGCGATGTTTGCTGCTGGCGATGTGGCCGCGGCCCGGATGGATGACGAGCACCTGTCGGTCATGTCGTGTCAGCATGGGCGCCCGATGGGCCGCTATGCCGGCTGCAACGTCATCAACGATCTGTTCGACCAACCGTTGCTGGCTCTTCGGATCCCTTGGTATGTCACGGTTCTCGATCTAGGATCGGCGGGCGCGGTGTACACCGAGGGATGGGAACGCAAAGTGGTATCGCAGGGCGCACCGGCCAAGACCACCAAGCAGTCAATCAATACCCGGCGGATCTACCCGCCGCTGAACGGCAGTCGGGCAGACTTGCTGGCTGCGGCCGCGCCGCGAGTACAGCCCCGCCCCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

NADH dehydrogenase family

GO

extracellular region GO:0005576 cellular_component
plasma membrane GO:0005886 cellular_component
oxidoreductase activity GO:0016491 molecular_function

InterPro

UniProt: P9WJJ1
GenBank: Rv1812c
EnsemblBacteria: Rv1812c
Mycobrowser: Rv1812c

Summary

Name: NADH dehydrogenase-like protein Rv1812c (EC 1.6.-.-)
Family: NADH dehydrogenase family
Protein Sequence: MTRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVMVVSNKPFHDIRVRNYEADLSACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGASYSYDRLVLASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTSAAATVVVVGAGLTGIETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALLDNGVETRTGVSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP
Mass: 41,956 Da
Length: 400 Aa

Rv1812c doesn't seem to be a targeted by any drug.

Oxidative phosphorylation mtu00190
mtu00190
PATHWAY_MAP mtu00190 Oxidative phosphorylation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.: J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.: J Exp Med. 2003 Sep 1;198(5):705-13. doi: 10.1084/jem.20030205.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.