Function

Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis (PubMed:17095513, PubMed:17223373, PubMed:24106104). The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3 (PubMed:17095513). Mediates Ca(2+)-dependent up-regulation of the anti-inflammatory cytokine IL-10 (PubMed:27483162). Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway (PubMed:26978522). {ECO:0000269|PubMed:17095513, ECO:0000269|PubMed:17223373, ECO:0000269|PubMed:24106104, ECO:0000269|PubMed:26978522, ECO:0000269|PubMed:27483162}.

Family

Mycobacterial PE family, PGRS subfamily

GO

• cell surface GO:0009986 cellular_component
• host cell surface receptor binding GO:0046789 molecular_function
• pathogenesis GO:0009405 biological_process
• cell outer membrane GO:0009279 cellular_component
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component
• modulation by symbiont of host innate immune response GO:0052167 biological_process
• response to oxygen levels GO:0070482 biological_process
• response to starvation GO:0042594 biological_process

InterPro

• IPR000084

UniProt

P9WIF5

GenBank

Rv1818c

EnsemblBacteria

Rv1818c

Mycobrowser

Rv1818c

Rv1818c doesn't seem to be a targeted by any drug.

Rv1818c doesn't seem to be involved in any pathway.