Gene - combatTB X

bacA

Type: protein_coding
Name: bacA
Locus Name: Rv1819c
Product: Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA
Functional Category: Cell wall and cell processes
Location: 2062809..2064728 (- strand)
Gene Length: 1919 bp
Nucleotides: TTGGGCCCGAAATTGTTTAAGCCGTCCATCGATTGGTCTAGAGCATTCCCGGATTCCGTGTATTGGGTCGGCAAAGCCTGGACGATCAGTGCCATCTGTGTGCTCGCGATATTGGTTCTGCTCAGGTATTTGACGCCCTGGGGCCGGCAGTTCTGGCGGATCACCCGCGCATACTTCGTTGGCCCCAACAGCGTTCGCGTGTGGCTGATGCTCGGCGTGTTGTTGCTTTCGGTAGTGCTGGCAGTGCGCCTGAATGTGCTATTCAGCTACCAAGGCAACGACATGTACACGGCCTTGCAGAAGGCCTTCGAGGGCATCGCCTCTGGCGATGGCACGGTCAAACGCTCAGGCGTGCGAGGATTTTGGATGTCGATCGGGGTTTTCAGCGTGATGGCCGTGCTGCACGTGACCCGGGTCATGGCCGACATCTACTTGACGCAGCGCTTCATCATCGCCTGGAGGGTCTGGCTAACCCACCACCTCACACAAGACTGGCTCGACGGCAGGGCCTACTACCGAGACCTGTTCATCGACGAAACGATCGACAACCCCGACCAGCGCATTCAGCAAGACGTCGATATCTTCACCGCCGGGGCAGGCGGCACTCCGAATGCTCCCTCCAACGGGACGGCCAGCACGCTGCTTTTCGGGGCCGTGCAGTCGATCATTTCGGTGATTTCTTTCACAGCGATCCTGTGGAATCTCTCGGGCACCCTGAATATCTTCGGCGTGTCCATCCCGCGCGCAATGTTCTGGACCGTGCTGGTCTATGTGTTCGTGGCCACGGTCATCTCGTTCATCATCGGGCGGCCCCTGATCTGGCTCAGCTTCCGCAATGAAAAGCTCAATGCCGCTTTCCGTTACGCGCTGGTTCGGCTACGCGACGCCGCCGAGGCGGTGGGTTTCTACCGCGGCGAGCGGGTGGAAGGTACCCAGCTACAGCGGCGGTTCACGCCGGTGATCGACAATTACCGTCGCTACGTTCGGCGCAGCATCGCATTCAATGGATGGAATCTGTCGGTGAGCCAGACAATTGTTCCGTTGCCGTGGGTCATCCAGGCGCCTCGATTATTCGCCGGGCAGATCGACTTCGGCGATGTCGGGCAGACGGCGACTTCCTTCGGCAACATTCACGACTCGTTGTCGTTCTTCCGCAACAACTACGACGCGTTTGCGTCCTTCCGCGCAGCAATCATCCGATTGCATGGGCTGGTCGACGCCAACGAGAAAGGCCGCGCCCTGCCCGCGGTCCTGACCCGACCGAGCGACGACGAGTCCGTCGAGCTCAACGACATCGAGGTGCGTACGCCTGCCGGCGATCGGTTGATCGACCCGCTCGATGTGCGGCTGGACCGCGGAGGCTCGCTGGTGATCACCGGGCGTTCTGGGGCCGGCAAGACCACGCTGCTGCGCAGTCTGGCGGAACTGTGGCCCTACGCATCGGGGACCCTGCACCGGCCGGGCGGCGAGAACGAGACGATGTTCTTGTCGCAGTTGCCGTATGTGCCGCTGGGGACGCTGCGTGACGTGGTGTGCTACCCCAACTCTGCGGCCGCCATCCCCGACGCCACCCTGCGGGACACGCTGACCAAGGTGGCGCTGGCCCCACTGTGTGACCGGCTGGACGAGGAACGCGACTGGGCCAAGGTGCTCTCCCCCGGTGAGCAGCAACGTGTTGCCTTTGCTCGCATCCTGCTCACCAAACCCAAGGCGGTCTTCCTCGACGAAAGTACCTCGGCGCTGGACACCGGGCTGGAGTTTGCGCTCTACCAATTGCTGCGCAGCGAGCTGCCGGACTGCATCGTGATCAGCGTCAGCCATCGCCCCGCCCTCGAGCGGCTGCACGAAAACCAGCTCGAACTACTCGGTGGCGGCCAATGGCGGCTGGCCCCAGTCGAGGCGGCGCCCGCCGAAGTGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections. {ECO:0000269|PubMed:18996991, ECO:0000269|PubMed:23407640}.

Family

ABC transporter superfamily

GO

plasma membrane GO:0005886 cellular_component
ATPase-coupled transmembrane transporter activity GO:0042626 molecular_function
response to host immune response GO:0052572 biological_process
integral component of plasma membrane GO:0005887 cellular_component
ATP binding GO:0005524 molecular_function
extracellular region GO:0005576 cellular_component

InterPro

UniProt: P9WQI9
GenBank: Rv1819c
EnsemblBacteria: Rv1819c
Mycobrowser: Rv1819c

Summary

Name: Vitamin B12 transport ATP-binding protein BacA
Family: ABC transporter superfamily
Protein Sequence: MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYLTPWGRQFWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQKAFEGIASGDGTVKRSGVRGFWMSIGVFSVMAVLHVTRVMADIYLTQRFIIAWRVWLTHHLTQDWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAGGTPNAPSNGTASTLLFGAVQSIISVISFTAILWNLSGTLNIFGVSIPRAMFWTVLVYVFVATVISFIIGRPLIWLSFRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAFNGWNLSVSQTIVPLPWVIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIRLHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRLDRGGSLVITGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLPYVPLGTLRDVVCYPNSAAAIPDATLRDTLTKVALAPLCDRLDEERDWAKVLSPGEQQRVAFARILLTKPKAVFLDESTSALDTGLEFALYQLLRSELPDCIVISVSHRPALERLHENQLELLGGGQWRLAPVEAAPAEV
Mass: 71,317 Da
Length: 639 Aa

Rv1819c doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

A vitamin B(1)(2) transporter in Mycobacterium tuberculosis.: Open Biol. 2013 Feb 13;3(2):120175. doi: 10.1098/rsob.120175.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis.: J Bacteriol. 2009 Jan;191(2):477-85. doi: 10.1128/JB.01132-08. Epub 2008 Nov 7.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.