pgsA2
- Type
- protein_coding
- Name
- pgsA2
- Locus Name
-
Rv1822
- Product
-
Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase)
- Functional Category
-
Lipid metabolism
- Location
- 2069080..2069709 (+ strand)
- Gene Length
- 629 bp
- Nucleotides
-
TGGAGCCGGTGCTCACGCAGAATCGGGTGCTGACTGTCCCCAACATGTTGAGCGTTATTCGCCTCGCGCTCATCCCAGCATTCGTCTACGTCGTGCTCAGCGCGCACGCCAATGGCTGGGGGGTAGCGATCCTGGTGTTCAGTGGCGTTTCGGACTGGGCTGATGGCAAGATTGCACGGCTACTAAACCAGTCATCGCGGCTGGGCGCGCTGCTGGACCCGGCCGTTGATCGCCTCTACATGGTCACTGTTCCTATCGTGTTTGGCCTGAGCGGCATCGTGCCGTGGTGGTTTGTCCTTACGTTGCTGACCCGCGATGCGCTGCTGGCTGGGACGCTGCCGCTGCTATGGAGCCGTGGACTGTCAGCGCTACCGGTGACCTACGTCGGTAAGGCAGCGACTTTCGGCTTCATGGTTGGCTTTCCGACCATTCTGTTGGGGCAATGCGATCCATTGTGGAGCCATGTGCTGCTGGCCTGTGGTTGGGCATTCTTGATCTGGGGTATGTATGCCTACTTGTGGGCCTTCGTGCTGTATGCAGTGCAGATGACGATGGTGGTGCGGCAGATGCCTAAGCTCAAGGGCAGGGCTCATCGGCCGGCGGCCCAGAACGCTGGTGAACGTGGCTGA
- Drug Resistance
- Mutations
- Function
- This protein catalyzes the committed step to the synthesis of the acidic phospholipids. {ECO:0000250}.
- Family
-
CDP-alcohol phosphatidyltransferase class-I family
- GO
-
- glycerophospholipid biosynthetic process GO:0046474 biological_process
- phospholipid biosynthetic process GO:0008654 biological_process
- plasma membrane GO:0005886 cellular_component
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity GO:0008444 molecular_function
- integral component of membrane GO:0016021 cellular_component
- phosphatidylglycerol biosynthetic process GO:0006655 biological_process
- InterPro
Summary
- Name
- Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase 1 (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase)
- Family
- CDP-alcohol phosphatidyltransferase class-I family
- Protein Sequence
-
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLACGWAFLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG
- Mass
- 22,911 Da
- Length
- 209 Aa
Rv1822 doesn't seem to be a targeted by any drug.
-
-
Glycerophospholipid metabolism mtu00564
mtu00564PATHWAY_MAP mtu00564 Glycerophospholipid metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.