Gene - combatTB X

Type: protein_coding
Name: ureF
Locus Name: Rv1851
Product: Urease accessory protein UreF
Functional Category: Intermediary metabolism and respiration
Location: 2099694..2100329 (+ strand)
Gene Length: 635 bp
Nucleotides: TGACCTCGCTGGCCGTGCTGCTCACCCTCGCCGACTCGCGGCTGCCCACGGGTGCGCACGTGCACTCGGGCGGCATCGAAGAAGCCATCGCCGCCGGCATGGTGACCGGCCTGGCCACCCTGGAAGCGTTCCTGAAACGGCGGGTCCGCACCCACGGCCTGCTGACGGCGTCCATCGCGGCCGCGGTGCACCGGGGCGAGCTGGCCGTCGACGACGCCGACCGGGAAACCGACGCGCGCACACCGGCTCCCGCGGCCAGACACGCCTCACGCAGCCAGGGCCGCGGGCTGATCAGGCTGGCACGGCGGGTGTGGCCCGATTCCGGCTGGGAGGAACTGGGCCCGAGGCCGCATCTGGCGGTTGTGGCCGGACGGGTCGGCGCGCTGAGCGGGCTGGCGCCCGAGCACAACGCCTTGCACCTCGTCTACATCACAATGACCGGCTCGGCCATCGCCGCCCAGCGACTGCTGGCGCTAGATCCCGCCGAAGTGACCGTGGTGACCTTCCAGCTGTCCGAACTGTGCGAGCAGATCGCGCAGGAGGCCACAGCCGGACTGGCAGACTTGTCTGATCCGCTGCTGGACACGCTCGCCCAGCGGCATGACGAGCGCGTGCGTCCCCTGTTCGTTTCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-Rule:MF_01385}.

Family

UreF family

GO

InterPro

Summary

Name: Urease accessory protein UreF
Family: UreF family
Protein Sequence: MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGMVTGLATLEAFLKRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLARRVWPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALDPAEVTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS
Mass: 22,356 Da
Length: 211 Aa

Rv1851 doesn't seem to be a targeted by any drug.

Rv1851 doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.: J Bacteriol. 1995 Oct;177(19):5644-52. doi: 10.1128/jb.177.19.5644-5652.1995.