Gene - combatTB X

modB

Type: protein_coding
Name: modB
Locus Name: Rv1858
Product: Probable molybdenum-transport integral membrane protein ABC transporter ModB
Functional Category: Cell wall and cell processes
Location: 2105773..2106567 (+ strand)
Gene Length: 794 bp
Nucleotides: TGCACCCGCCTACGGATCTGCCTCGTTGGGTATATCTCCCGGCGATCGCGGGGATCGTGTTCGTGGCAATGCCGCTGGTCGCGATCGCCATCCGGGTCGATTGGCCGCGTTTCTGGGCGCTGATCACTACTCCGTCTTCTCAAACGGCCCTGCTGTTGAGCGTGAAGACCGCCGCGGCCAGCACGGTGCTGTGCGTACTGCTGGGCGTCCCGATGGCGCTGGTGCTGGCCCGCAGCCGCGGACGACTGGTGCGGTCGTTACGACCGCTGATCCTGTTACCGCTGGTGCTGCCGCCGGTAGTCGGGGGTATCGCGTTGCTCTACGCGTTCGGCCGGCTCGGCCTGATCGGGCGCTACCTGGAGGCGGCCGGCATCAGCATCGCATTCAGTACCGCGGCTGTGGTGCTGGCGCAGACCTTTGTCTCGCTGCCGTATCTGGTGATTTCCCTAGAGGGTGCAGCCCGCACCGCCGGAGCCGACTACGAGGTGGTGGCGGCGACACTTGGGGCGCGGCCCGGCACTGTCTGGTGGCGCGTGACCCTGCCGTTGCTGCTCCCGGGCGTGGTGTCCGGATCAGTACTGGCGTTTGCCCGCTCGCTCGGAGAGTTTGGCGCGACCCTAACCTTTGCCGGTTCCCGGCAAGGGGTCACCCGTACCCTTCCGCTGGAGATTTACCTGCAGCGGGTGACCGATCCGGACGCGGCGGTGGCATTGTCACTGCTGCTCGTTGTGGTAGCGGCACTGGTGGTGCTGGGTGTGGGTGCTCGTACGCCGATCGGGACCGATACCAGGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the binding-protein-dependent transport system ModABCD for molybdenum; probably responsible for the translocation of the substrate across the membrane. {ECO:0000250}.

Family

Binding-protein-dependent transport system permease family, CysTW subfamily

GO

plasma membrane GO:0005886 cellular_component
molybdate ion transmembrane transporter activity GO:0015098 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WG13
GenBank: Rv1858
EnsemblBacteria: Rv1858
Mycobrowser: Rv1858

Summary

Name: Molybdenum transport system permease protein ModB
Family: Binding-protein-dependent transport system permease family, CysTW subfamily
Protein Sequence: MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTPSSQTALLLSVKTAAASTVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGIALLYAFGRLGLIGRYLEAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEVVAATLGARPGTVWWRVTLPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPLEIYLQRVTDPDAAVALSLLLVVVAALVVLGVGARTPIGTDTR
Mass: 27,676 Da
Length: 264 Aa

Rv1858 doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.