Gene - combatTB X

Rv1867

Type: protein_coding
Name: Rv1867
Locus Name: Rv1867
Product: Conserved protein
Functional Category: Lipid metabolism
Location: 2115764..2117248 (+ strand)
Gene Length: 1484 bp
Nucleotides: TGCCGGTAGACCCCAGGACGCCAGTGCTGATCGGCTATGGACAGGTCAACCACCGAGGCGACATCGACGCCGAGAAGCAGTCCATCGAACCCGTCGACCTGATGGCCGCCGCGGCCCGGAAAGCCGCGGATTCGACGGTGCTCGAGGCGGTGGATTCGATCCGTGTGGTGCACATGCTGTCGGCGCATTACCGGAATCCCGGGCAGCTCCTCGGCGAACGAATCAAGGCGAGGACCTTCACCACCGGTTACAGCGGGGTGGGCGGCAACATGCCGCAATCCCTGGTCAACCGGGCATGCCTGGACATCCAGCGCGGGCGGGCCGGCGTGGTGCTGCTGGCTGGCGCCGAAACCTGGCGCACCCGAACGGGCCTGCGCGCCAAGGGCAGCAAACTGGAGTGGACTGTGCAGGACGAATCCGTTCCGCTGCCGGACATGGCCGGCGACGACGTTCCGATGGCCGGTGCGGCTGAGCTGCGGATCAACCTGGACCGGCCGGCCTACGTGTACCCGATATTCGAGCAGGCGCTGCGCATCGCCTACGGCGAGTCGATCGAGAACCACCGAAAGCGGATCGGCGAGCTGTGGGCGCGGTTCAGTGCCGTAGCTGCTGACAACCCGCACGCGTGGATCCGCAACCCGGTTACGGCTGACGAGATCTGGCAGCCCGGCCCACAGAACCGGATGGTCAGCTGGCCCTACACCAAGCTTATGAACTCCAACAACATGGTTGACCAGGGTGCCGCGCTGCTGCTGACGTCGGTCGAACGTGCGACACGTCTGCGAATACCGGCCGAACGCTGGGTTTATCCACAGGCTGGCACCGACGCCCACGACACACCGGCCGTCGCCGACCGCCACCGACTGCATCGGTCGACGGCCATTCGGATCGCCGGTGCCCGGGCGCTGGAACTGGCTGGGCTGGGGCTCGATGACATCGAATACGTCGACCTGTATTCGTGCTTTCCCTCCGCTGTCCAAGTCGCCGCAATCGAACTCGGCCTGGACACCGACGATCCTGCCCGCCCGCTGACCGTCACCGGGGGCCTGACCTTCGCCGGCGGGCCGTGGAGCAATTACGTCACGCACTCCATCGCCACCATGGCTGAACTGCTGGCGGCCAATCCCGGGCGCCGAGGCCTGATCACCGCCAACGGCGGTTACCTGACCAAACACAGTTTCGGGGTCTACGGCACCGAGCCGCCGTCGGAATTCCGCTGGGAGGACATGCAACCCGCGGTCGATAGGGAGCCCACCGGAGATGGGTTGGTCGAGTGGGAAGGCATCGGCACCGTCGAAGCGTGGACCACACCAGTCAACCGGGACGGACAACCCGAGAAGGCGTTCCTGGCGGTGCGCACGCCCGACGGGTCGCGCAGCTTGGCCGTGATCACCGATCCCGCATCGGTGCAAGCAACGGTGCGCGAGGACATCGCCGGCGTCAAGGTTGCCGTCGCCCCCGACGGCACCGCGACCCTGCGATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

acetyl-CoA C-acyltransferase activity GO:0003988 molecular_function
acetyl-CoA C-acetyltransferase activity GO:0003985 molecular_function
cell wall GO:0005618 cellular_component
fatty acid beta-oxidation GO:0006635 biological_process

InterPro

UniProt: P95148
GenBank: Rv1867
EnsemblBacteria: Rv1867
Mycobrowser: Rv1867

Summary

Name: Conserved protein
Family: Unknown
Protein Sequence: MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAARKAADSTVLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYGESIENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQPGPQNRMVSWPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGLDTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITANGGYLTKHSFGVYGTEPPSEFRWEDMQPAVDREPTGDGLVEWEGIGTVEAWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKVAVAPDGTATLR
Mass: 53,560 Da
Length: 494 Aa

Rv1867 doesn't seem to be a targeted by any drug.

Two-component system mtu02020
mtu02020
Environmental Information Processing; Signal transduction

Terpenoid backbone biosynthesis mtu00900
mtu00900
Metabolism; Metabolism of terpenoids and polyketides

Butanoate metabolism mtu00650
mtu00650
PATHWAY_MAP mtu00650 Butanoate metabolism

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

Glyoxylate and dicarboxylate metabolism mtu00630
mtu00630
PATHWAY_MAP mtu00630 Glyoxylate and dicarboxylate metabolism

Pyruvate metabolism mtu00620
mtu00620
PATHWAY_MAP mtu00620 Pyruvate metabolism

Tryptophan metabolism mtu00380
mtu00380
PATHWAY_MAP mtu00380 Tryptophan metabolism

Benzoate degradation mtu00362
mtu00362
PATHWAY_MAP mtu00362 Benzoate degradation

Lysine degradation mtu00310
mtu00310
PATHWAY_MAP mtu00310 Lysine degradation

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Synthesis and degradation of ketone bodies mtu00072
mtu00072
PATHWAY_MAP mtu00072 Synthesis and degradation of ketone bodies

Fatty acid degradation mtu00071
mtu00071
PATHWAY_MAP mtu00071 Fatty acid degradation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.