Gene - combatTB X

PPE34

Type: protein_coding
Name: PPE34
Locus Name: Rv1917c
Product: PPE family protein PPE34
Functional Category: Pe/ppe
Location: 2162932..2167311 (- strand)
Gene Length: 4379 bp
Nucleotides: ATGAATTTTTCAACATTGCCACCAGAGATCAACTCGGCCCTCATATTCGGCGGGGCGGGATCAGAACCCATGTCGGCGGCCGCGGTCGCCTGGGACCAACTGGCGATGGAATTGGCCTCGGCAGCGGCCTCTTTCAACTCCGTGACGTCGGGCCTGGTCGGCGAATCGTGGCTCGGACCGTCATCGGCGGCGATGGCCGCTGCGGTAGCGCCGTACCTAGGATGGCTTGCCGCGGCAGCGGCCCAGGCCCAGCGGTCGGCAACCCAAGCCGCGGCCCTCGTGGCCGAGTTCGAGGCTGTCCGGGCGGCGATGGTGCAACCGGCGCTGGTGGCGGCCAACCGCTCCGACCTGGTGTCATTGGTGTTCTCAAACTTCTTCGGGCAGAATGCTCCGGCGATCGCTGCGATTGAGGCCGCATACGAACAGATGTGGGCCATCGATGTGTCGGTGATGTCGGCCTACCATGCCGGGGCATCGGCGGTGGCGTCGGCCCTGACGCCGTTCACTGCGCCGCCGCAGAATCTGACAGACCTGCCCGCCCAGTTGGCGGCCGCTCCGGCGGCCGTCGTCACCGCGGCGATCACCAGTTCCAAGGGTGTGCTGGCAAATCTTAGCTTAGGCCTGGCAAACTCGGGCTTCGGACAGATGGGCGCCGCTAACCTTGGCATTTTGAACTTGGGCAGCCTAAATCCCGGCGGCAACAACTTCGGCCTTGGAAATGTCGGCAGCAACAACGTTGGCTTGGGCAACACCGGCAACGGAAACATCGGCTTCGGCAACACGGGCAACGGAAACATCGGCTTCGGCCTCACCGGCGACAACCAGCAGGGGTTCGGCGGCTGGAACTCGGGGACCGGCAATATCGGCTTGTTCAACTCAGGCACCGGCAACATCGGCATCGGCAATACGGGCACCGGAAACTTCGGCATCGGGAACTCAGGTACCAGCTACAACACGGGTATCGGCAACACGGGCCAAGCCAACACGGGCTTCTTCAACGCCGGCATCGCCAACACTGGCATCGGCAACACGGGCAACTACAACACGGGCAGCTTCAATCTAGGCAGCTTCAACACGGGCGACTTCAACACGGGCAGCTCCAACACAGGCTTCTTCAACCCCGGCAACCTCAACACCGGCGTGGGAAACACCGGCAACGTCAACACCGGTGGATTCAACTCTGGCAACTACAGCAACGGCTTCTTCTGGCGAGGCGACTACCAGGGCTTGATCGGCTTCTCCGGCACACTGACCATTCCCGCTGCTGGCCTAGACCTCAACGGCCTCGGCTCCGTCGGCCCCATCACCATCCCGTCCATCACCATTCCCGAAATCGGCCTGGGCATTAACAGTTCCGGAGCGTTGGTGGGGCCGATCAATGTTCCGCCTATTACTGTTCCCGCCATCGGGCTGGGCATCAACAGTACCGGGGCACTCGTTGGCCCCATCAACATCCCGCCGATCACTCTAAATTCTATTGGCCTAGAGCTATCGGCGTTCCAGGTCATTAACGTGGGATCGATTTCGATCCCCGCGTCTCCGCTTGCGATCGGCTTATTCGGCGTAAATCCCACCGTTGGCAGCATAGGCCCGGGTAGCATATCGATACAGCTAGGCACTCCTGAGATTCCCGCGATTCCGCCATTTTTCCCCGGATTCCCTCCAGATTACGTGACAGTGAGTGGTCAAATCGGTCCCATCACCTTCTTATCGGGTGGTTATAGTTTGCCGGCTATTCCGTTGGGTATTGATGTGGGTGGAGGGTTAGGCCCGTTTACGGTGTTCCCGGATGGCTACTCACTTCCGGCAATCCCGTTGGGTATTGATGTGGGCGGAGGGTTAGGCCCGTTTACGGTGTTCCCGGATGGCTACTCACTTCCGGCAATCCCGTTGGGTATTGATGTGGGCGGAGGGTTAGGCCCGTTTACGGTGTTCCCGGATGGCTACTCACTTCCGGCAATCCCGTTGGGTATTGATGTGGGCGGCGCCATCGGCCCCCTCACTACCCCGCCAATCACGATCCCCTCAATCCCGTTGGGCATCGACGTGTCCGGCAGCCTCGGGCCGATCAACATCCCGATCGAAATCGCGGGCACCCCAGGCTTCGGAAACTCGACCACCACCCCGTCATCGGGCTTCTTCAACAGCGGTACGGGCGGCACATCGGGTTTCGGGAACGTCGGTTCGGGCGGATCTGGCTTCTGGAACATTGCTGGGAATCTCGGCAACTCCGGATTCCTTAACGTCGGGCCACTGACATCGGGAATCTTGAACTTCGGCAACACAGTCTCAGGCCTCTACAACACCAGCACGCTGGGCCTAGCGACATCGGCCTTTCACTCCGGCGTCGGTAACACCGACAGCCAACTCGCCGGCTTCATGCGCAACGCCGCAGGTGGGACGTTATTCAACTTCGGCTTCGCCAACGACGGCACACTCAACTTGGGCAACGCAAACCTCGGCGACTACAACGTGGGTAGCGGAAACGTCGGTAGCTACAACTTCGGTAGCGGAAACATCGGCAACGGAAGTTTCGGTTTCGGAAACATCGGAAGCAACAACTTCGGTTTTGGAAACGTCGGCAGCAACAACCTTGGGTTTGCAAACACGGGTCCGGGGTTGACGGAGGCCCTGCACAACATTGGCTTTGGGAACATCGGCGGCAACAACTACGGCTTCGCGAACATCGGTAACGGCAACATCGGCTTCGGCAACACGGGCACTGGAAATATTGGTATCGGGCTCACCGGCGACAATCAGGTCGGATTCGGGGCGCTGAACTCCGGCAGCGGCAACATCGGCTTCTTCAACTCCGGCAACGGCAACATCGGCTTCTTCAACTCAGGCAACGGAAACGTCGGCATCGGCAACTCCGGCAACTACAACACCGGCCTGGGTAACGTGGGCAACGCCAACACGGGCCTGTTCAACACCGGCAACGTCAACACTGGAATCGGCAACGCAGGAAGCTACAACACAGGCAGCTACAACGCCGGCGACACCAACACGGGCGACCTCAACCCGGGCAACGCCAACACGGGGTACCTAAACCTCGGCGACCTCAACACCGGCTGGGGAAACATTGGCGACCTTAACACCGGCGCCCTGATCTCGGGCAGCTACAGCAACGGCATACTGTGGAGGGGCGATTACCAGGGTCTGATTGGCTACTCAGACACACTCAGCATTCCCGCCATCCCACTGAGCGTCGAAGTGAATGGTGGCATCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGCGCTGGGTGGTGTCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGCGCTGGGTGGTGTCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGCGCTGGGTGGTGTCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGCGCTGGGTGGTGTCGGTCCGATTGTGGTGCCTGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGCGCTGGGTGGTGTCGGTCCGATCACCGTTCCCGGCGTCCCTATTTCCCGCATCCCCCTTACGATTAACATCAGGATACCGGTCAACATCACTCTCAACGAACTTCCGTTTAACGTCGCTGGTATCTTCACGGGCTACATCGGCCCCATCCCGCTTAGCACATTCGTATTAGGCGTCACGCTGGCCGGCGGCACCCTGGAGTCTGGCATCCAGGGATTCAGTGTTAATCCGTTCGGTTTGAATATTCCGCTGAGCGGTGCTACCAACGCTGTCACGATCCCTGGTTTCGCGATTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCCTGGTTTCGCGATTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCCCGGCTTCACCATTCCCGGATCCCCCCTGAACTTGACCGCCAACGGCGGCTTGGGACCGATCAACATCCCGATCAACATCACGAGCGCCCCGGGCTTCGGAAACTCCACCACCACCCCGTCTTCGGGCTTCTTCAACAGTGGCGATGGAAGCGCATCCGGCTTCGGCAACGTCGGGCCCGGCATTTCGGGCCTCTGGAACCAGGTGCCGAACGCGCTGCAAGGCGGAGTCTCGGGAATCTACAACGTCGGGCAGCTGGCGTCGGGCGTGGCGAACCTAGGCAACACCGTCTCGGGCTTCAACAACACGAGCACCGTTGGTCACCTCACCGCTGCGTTTAACTCGGGCGTCAACAACATCGGCCAAATGCTCCTGGGCTTCTTCTCACCGGGTGCCGGGCCGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL-4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-kappa-B signaling pathways. {ECO:0000269|PubMed:20837474}.

Family

Mycobacterial PPE family

GO

cell surface GO:0009986 cellular_component
plasma membrane GO:0005886 cellular_component
modulation by symbiont of host immune response GO:0052553 biological_process
extracellular region GO:0005576 cellular_component
cell wall GO:0005618 cellular_component
pathogenesis GO:0009405 biological_process

InterPro

UniProt: Q79FI9
GenBank: Rv1917c
EnsemblBacteria: Rv1917c
Mycobrowser: Rv1917c

Summary

Name: PPE family protein PPE34
Family: Mycobacterial PPE family
Protein Sequence: MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAASFNSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRAAMVQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASAVASALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGAANLGILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQGFGGWNSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNAGIANTGIGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGFNSGNYSNGFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGINSSGALVGPINVPPITVPAIGLGINSTGALVGPINIPPITLNSIGLELSAFQVINVGSISIPASPLAIGLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVSGQIGPITFLSGGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPITIPSIPLGIDVSGSLGPINIPIEIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGGSGFWNIAGNLGNSGFLNVGPLTSGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQLAGFMRNAAGGTLFNFGFANDGTLNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGNIGSNNFGFGNVGSNNLGFANTGPGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGTGNIGIGLTGDNQVGFGALNSGSGNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGNVGNANTGLFNTGNVNTGIGNAGSYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWGNIGDLNTGALISGSYSNGILWRGDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRIPLTINIRIPVNITLNELPFNVAGIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVNPFGLNIPLSGATNAVTIPGFAINPFGLNVPLSGGTSPVTIPGFAINPFGLNVPLSGGTSPVTIPGFTIPGSPLNLTANGGLGPINIPINITSAPGFGNSTTTPSSGFFNSGDGSASGFGNVGPGISGLWNQVPNALQGGVSGIYNVGQLASGVANLGNTVSGFNNTSTVGHLTAAFNSGVNNIGQMLLGFFSPGAGP
Mass: 142,944 Da
Length: 1459 Aa

Rv1917c doesn't seem to be a targeted by any drug.

Rv1917c doesn't seem to be involved in any pathway.

Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses.: J Biol Chem. 2010 Nov 19;285(47):36511-22. doi: 10.1074/jbc.M110.158055. Epub 2010 Sep 13.
Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c.: Tuberculosis (Edinb). 2001;81(5-6):305-17. doi: 10.1054/tube.2001.0304.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.