Gene - combatTB X

Type: protein_coding
Name: mpt63
Locus Name: Rv1926c
Product: Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Functional Category: Cell wall and cell processes
Location: 2178957..2179436 (- strand)
Gene Length: 479 bp
Nucleotides: ATGAAGCTCACCACAATGATCAAGACGGCAGTAGCGGTCGTGGCCATGGCGGCCATCGCGACCTTTGCGGCACCGGTCGCGTTGGCTGCCTATCCCATCACCGGAAAACTTGGCAGTGAGCTAACGATGACCGACACCGTTGGCCAAGTCGTGCTCGGCTGGAAGGTCAGTGATCTCAAATCCAGCACGGCAGTCATCCCCGGCTATCCGGTGGCCGGCCAGGTCTGGGAGGCCACTGCCACGGTCAATGCGATTCGCGGCAGCGTCACGCCCGCGGTCTCGCAGTTCAATGCCCGCACCGCCGACGGCATCAACTACCGGGTGCTGTGGCAAGCCGCGGGCCCCGACACCATTAGCGGAGCCACTATCCCCCAAGGCGAACAATCGACCGGCAAAATCTACTTCGATGTCACCGGCCCATCGCCAACCATCGTCGCGATGAACAACGGCATGGAGGATCTGCTGATTTGGGAGCCGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

InterPro

Summary

Name: Immunogenic protein MPT63 (16 kDa immunoprotective extracellular protein) (Antigen MPT63)
Family: Unknown
Protein Sequence: MKLTTMIKTAVAVVAMAAIATFAAPVALAAYPITGKLGSELTMTDTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNARTADGINYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP
Mass: 16,514 Da
Length: 159 Aa

Rv1926c doesn't seem to be a targeted by any drug.

Rv1926c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis.: Infect Immun. 1991 Jan;59(1):372-82.
Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1530-4. doi: 10.1073/pnas.92.5.1530.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
High-level heterologous expression and secretion in rapidly growing nonpathogenic mycobacteria of four major Mycobacterium tuberculosis extracellular proteins considered to be leading vaccine candidates and drug targets.: Infect Immun. 1997 Jun;65(6):2321-8.
Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis.: Infect Immun. 1997 Jan;65(1):16-23.